Article
Agriculture, Multidisciplinary
Wenhao Li, Lijian Ding, Juan Li, Huimin Wen, Yang Liu, Shuangling Tan, Xiaojun Yan, Yutong Shi, Wenhan Lin, Hou-Wen Lin, Shan He
Summary: Researchers isolated eight novel antimycins from an oceanic mesophotic zone Streptomyces sp., and one of the compounds showed excellent inhibitory activities against gray mold of apple.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Organic
Md Rokon Ul Karim, Yasuko In, Tao Zhou, Enjuro Harunari, Naoya Oku, Yasuhiro Igarashi
Summary: Two bicyclic peptides, nyuzenamides A and B, isolated from Streptomyces in deep sea water collected in the Sea of Japan, exhibited antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells. The structures of these compounds, comprising ten amino acid residues with four unusual amino acids and aromatic acyl units, were determined through various analytical methods.
Article
Plant Sciences
Zsolt Szucs, Tamas Plaszko, Eszter Bodor, Hajnalka Csoma, Lajos Acs-Szabo, Attila Kiss-Szikszai, Gabor Vasas, Sandor Gonda
Summary: The glucosinolates of Brassicaceae plants can be converted into bioactive isothiocyanates and other volatiles during stressful conditions. However, the role of weaker alternative products, such as nitriles, is not well understood.
Article
Biotechnology & Applied Microbiology
Sawai Boukaew, Zhiwei Zhang, Poonsuk Prasertsan, Yasuhiro Igarashi
Summary: This study reports the antifungal and antiaflatoxigenic activity of freeze-dried culture filtrate of Streptomyces philanthi RL-1-178 against aflatoxigenic strains, and identifies its active component as natamycin. The study also reveals that DCF RL-1-178 significantly impairs antioxidant defense enzymes and molecules in the aflatoxigenic cells.
JOURNAL OF APPLIED MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hanbeen Kim, Jakyeom Seo
Summary: Two potential endolysins were identified, with one showing better efficacy against MRSA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Melissa J. Karau, Suzannah M. Schmidt-Malan, Scott A. Cunningham, Jayawant N. Mandrekar, Bobbi S. Pritt, Tiffany R. Keepers, Alisa W. Serio, Surya Chitra, Robin Patel
Summary: Omadacycline, vancomycin, and rifampin, as well as rifampin combination therapies, were evaluated in an experimental rat model of MRSA osteomyelitis. The results showed that rifampin combination therapy was effective in reducing MRSA recovery without developing resistance. The combination of omadacycline and rifampin yielded negative MRSA detection, suggesting its potential as a treatment for osteomyelitis.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
Yinan Wang, Di Yang, Yuhui Bi, Zhiguo Yu
Summary: Four new 20-membered macrolides named venturicidins G-J were isolated from a Streptomyces sp. SN5452 culture, along with two known compounds venturicidins A and B. These compounds showed significant inhibition against the growth and germination of Pyricularia oryzae, suggesting their potential as novel fungicides for controlling rice blast.
Review
Biochemistry & Molecular Biology
Priyia Pusparajah, Vengadesh Letchumanan, Jodi Woan-Fei Law, Nurul-Syakima Ab Mutalib, Yong Sze Ong, Bey-Hing Goh, Loh Teng-Hern Tan, Learn-Han Lee
Summary: Methicillin-resistant S. aureus (MRSA) biofilms are a common cause of biomedical device-related infections, requiring new and effective antibiofilm agents. Promising anti-MRSA biofilm agents from Streptomyces bacteria have been reviewed, showing potential in preventing and eradicating MRSA biofilms. Further in vivo studies and clinical trials are needed to assess the prospects of these new strategies for biofilm-related infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Hui Zhao, Lu Liu, Lingshuang Yang, Qihui Gu, Ying Li, Jumei Zhang, Shi Wu, Moutong Chen, Xinqiang Xie, Qingping Wu
Summary: The study identified a strain FJKB0103 isolated from the rhizosphere of Garcinia mangostana with strong anti-MRSA activity. Through genomic analysis, the researchers discovered that DAPG produced by the strain was the compound responsible for its activity. DAPG was found to be effective against MRSA strains and could inhibit biofilm formation.
Article
Agriculture, Multidisciplinary
Ruiyuan Liu, Zhuangzhuang Li, Sifan Liu, Jinshuo Zheng, PanPan Zhu, Bin Cheng, Ruijin Yu, Huiling Geng
Summary: A series of simple diarylhydrazide derivatives were designed, prepared, and screened for their antifungal activities. The most active compound, 2c, showed significant activity against various plant pathogens in vitro and in vivo. Furthermore, 2c demonstrated no toxicity towards cowpea seed germination and normal human hepatocytes.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Plant Sciences
Robert W. Schumacher, Amanda L. Waters, Jiangnan Peng, Richard A. Schumacher, Ailish Bateman, Josie Thiele, Andrew J. Mitchell, Samuel G. Miller, Arthur Goldberg, Siddharth K. Tripathi, Ameeta K. Agarwal, Yike Zou, Yeun-Mun Choo, Mark T. Hamann
Summary: Two new lactone lipids, scoriosin (1) and its methyl ester (2), with unique structures were isolated from Scorias spongiosa, showing potent antimicrobial activities and potential utility in combination therapies for treating cryptococcal infections.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
David Rios, Jaime A. Valderrama, Gonzalo Quiroga, Jonathan Michea, Felipe Salas, Eduardo Alvarez Duarte, Edmundo A. Venegas-Casanova, Rafael Jara-Aguilar, Carlos Navarro-Retamal, Pedro Buc Calderon, Julio Benites
Summary: The limited antifungal options and high toxicity of drugs contribute to the high rates of morbidity and mortality caused by fungal infections. This study evaluated the antifungal activity of two acylphenols series in vitro and found that some compounds showed comparable MIC values to standard antifungal treatments for certain Candida strains. One compound also exhibited moderate antioxidant activity.
Article
Immunology
Lulu An, Gengpei Jia, Jingwen Tan, Lianjuan Yang, Yuemei Wang, Lei Li
Summary: In this study, a microdilution assay was used to explore the synergistic antifungal activity of everolimus in combination with itraconazole, voriconazole, posaconazole, and amphotericin B against a range of clinical dematiaceous fungal isolates. The results showed that the combination of everolimus with posaconazole and itraconazole exhibited superior in vitro synergistic efficacy, inhibiting the growth of most tested strains. On the other hand, the combination with amphotericin B showed limited efficacy, and no synergistic effect was observed with voriconazole. Overall, the findings suggest that everolimus can be synergistically combined with existing antifungal drugs to improve their efficacy in the treatment of chromoblastomycosis.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Moxi Yu, Yachen Hou, Meiling Cheng, Yongshen Liu, Caise Ling, Dongshen Zhai, Hui Zhao, Yaoyao Li, Yamiao Chen, Xiaoyan Xue, Xue Ma, Min Jia, Bin Wang, Pingan Wang, Mingkai Li
Summary: Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are difficult to treat due to antibiotic resistance, posing a significant threat to public health. A study examined the antibacterial activity of novel squaric amide derivatives against MRSA strains. The results showed that one derivative, squaric amide 2 (SA2), exhibited strong bactericidal activity, reduced infection size and bacterial count in an animal model.
Article
Microbiology
Monika Kumaraswamy, Kamilla Wiull, Bishnu Joshi, George Sakoulas, Armin Kousha, Gustav Vaaje-Kolstad, Mona Johannessen, Kristin Hegstad, Victor Nizet, Fatemeh Askarian
Summary: This study revealed that MRSA-derived MVs are capable of reducing the pathogen's susceptibility to VAN, thereby increasing its resistance to treatment, particularly in interactions with human neutrophils. Additionally, the elevated expression of proteins associated with antibiotic resistance in MVs may further impact MRSA's resistance.
Article
Biophysics
Salah M. Tawfik, Mohamed R. Elmasry, Mirkomil Sharipov, Shavkatjon Azizov, Chang Hyun Lee, Yong-Ill Lee
BIOSENSORS & BIOELECTRONICS
(2020)
Article
Biochemical Research Methods
Shavkatjon Azizov, Mirkomil Sharipov, Jae-Min Lim, Salah M. Tawfik, Nuritdin Kattaev, Yong-Ill Lee
Summary: The study presents a novel microfluidic paper-based analytical device coupled with paper spray mass spectrometry for efficient and low-cost quantitative determination of C-18-ceramide as a prognostic biomarker. The device demonstrated high resistance to organic solvents and efficiency in sample analysis, achieving good recovery values in human serum samples. The method simplifies the experimental steps and operation process, allowing for the identification of subnanomolar concentrations of C-18-ceramide.
JOURNAL OF MASS SPECTROMETRY
(2021)
Review
Chemistry, Multidisciplinary
Salah M. Tawfik, Shavkatjon Azizov, Mohamed R. Elmasry, Mirkomil Sharipov, Yong-Ill Lee
Summary: Nanomicelles as drug carriers show potential in selective and efficient drug delivery, forming organized structures through self-assembly and releasing drugs in response to various stimuli. The properties of core and corona forming blocks determine the size and shape of nanomicelles.
Article
Biochemical Research Methods
Ji-Yeon Kim, Woo Hong Joo, Dong-Soo Shin, Yong-Ill Lee, Chin Fen Teo, Jae-Min Lim
Summary: This study expanded the quantitative glycomic toolbox by optimizing the MILPIG approach in baker's yeast, demonstrating the requirement for carbon-13 labeled glucose incorporation and method robustness. The quantitation of the inhibitory effect of the N-linked glycosylation inhibitor tunicamycin on the yeast glycan expression profile was also performed.
ANALYTICAL BIOCHEMISTRY
(2021)
Article
Polymer Science
Amr S. Ismail, Salah M. Tawfik, Amr H. Mady, Yong-Ill Lee
Summary: Nanocomposites of tungsten oxide (WO3) and zinc oxide (ZnO) enriched polyethylene sebacate (PES) were successfully prepared and characterized in this study. The nanocomposites showed promising electrical activity and antimicrobial effects against bacteria and fungi, indicating potential for use in various applications such as catalysis.
Article
Chemistry, Multidisciplinary
Ming Han, Yuwei Liu, Dong-Jin Qian, Yong-Ill Lee, Hong-Guo Liu
Summary: The study developed a modified liquid/liquid interfacial epitaxial growth method to successfully prepare large-area ultrathin ordered films. The formation of the ultrathin films was found to be a result of the synergistic effects of various factors, providing a new approach for fabricating larger-area thin films of amphiphilic molecules.
Article
Chemistry, Multidisciplinary
Yuwei Liu, Xiaona Cui, Yong-Ill Lee, Hong-Guo Liu
Summary: This study systematically investigated the self-assembly behavior of polystyrene-block-poly(2-vinylpyridine) at the liquid/liquid interface. Different primary morphologies of aggregates were obtained depending on the molecular structure of the block copolymers and the amount of chloroauric acid. The findings provide valuable insights into the self-assembly behavior of block copolymers at interfaces and offer a facile approach for fabricating functional structures.
Review
Chemistry, Multidisciplinary
Zayakhuu Gerelkhuu, Yong-Ill Lee, Tae Hyun Yoon
Summary: This review describes the potential applications of upconversion nanomaterials (UCNMs) in biomedical fields, including drug delivery, bioimaging, biosensing, and photodynamic therapy. The mechanisms, synthesis methods, and biological toxicity of UCNMs are discussed, and the prospects for clinical applications are explored.
Article
Chemistry, Multidisciplinary
Seong-Soo Lee, Mirkomil Sharipov, Won June Kim, Yong-Ill Lee
Summary: Poly(ionic liquids) (PILs) have been widely used for CO2 capture due to their resemblance to ionic liquids and properties of polymers. In this study, the amine-functionalized poly(vinylimidazole)-based PIL (PVIm-NH2) was successfully prepared and characterized as a chemosensor for CO2 gas detection. The detection limit of PVIm-NH2 in the presence of triethylamine (TEA) was found to be 2.86 x 10-3 M with R2 = 0.9906. The mechanism of PVIm-NH2 generating N-heterocyclic carbenes (NHCs) in the presence of TEA and their reaction with CO2 gas to form a carboxylic acid was investigated. Structural modifications of PIL were also shown to make it a promising candidate for chemosensor applications.
Article
Biotechnology & Applied Microbiology
Salah M. Tawfik, Atef S. Kobisy, Emad A. Badr, Ahmed H. Elged, Yong-Ill Lee
Summary: Microbial corrosion caused by microorganisms in the petroleum industry is a significant problem that can have severe environmental and economic consequences. Therefore, the development of innovative nonionic porous antimicrobial materials with diverse hydrophobic conjugated motifs is highly desirable.
ENVIRONMENTAL TECHNOLOGY & INNOVATION
(2023)
Article
Nanoscience & Nanotechnology
Phommachith Sonexai, Minh Van Nguyen, Bui The Huy, Yong -Ill Lee
Summary: The detection of harmful chemicals in the environment and for food safety is important, but traditional techniques are expensive and time-consuming. Surface-enhanced Raman spectroscopy (SERS) offers a powerful alternative for detecting low concentrations of chemical compounds and biomolecules. This study presents a reproducible method for producing Ag nanoparticles that can be used to create highly sensitive SERS substrates. The developed SERS substrate exhibits exceptional analytical performance and has the potential to be a valuable analytical tool for monitoring environmental contaminants.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2023)
Article
Chemistry, Analytical
Salah M. Tawfik, Ali A. Abd-Elaal, Yong-Ill Lee
Summary: The design of multifunctional sensors based on conjugated polythiophene-quantum dots shows promise for detecting Hg2+ and TATP. The sensor demonstrates good linear response to Hg2+ and TATP under optimized conditions.
Article
Materials Science, Multidisciplinary
Mirkomil Sharipov, Youngil Lee, Jinsol Han, Yong-Ill Lee
Summary: Stabilizing silver cations from reactive ink with PVP on HEC-modified paper induces the formation of silver metal nanoparticles, achieving uniform formation and high conductivity of silver nanoparticles. The modified paper prevents the formation of silver oxides and silver acetate salts, allowing for a lower curing temperature and high conductivity.
MATERIALS ADVANCES
(2021)
Article
Chemistry, Multidisciplinary
Pavithra V. Ravi, Daniel T. Thangadurai, Kasi Nehru, Yong Ill Lee, Devaraj Nataraj, Sabu Thomas, Nandakumar Kalarikkal, Jiya Jose
Article
Chemistry, Analytical
Bui The Huy, Nguyen Ngoc Nghia, Yong-Ill Lee
MICROCHEMICAL JOURNAL
(2020)
