Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp

The Evolutionary Origins of Detoxifying Enzymes

(2013) Hagit Bar-Rogovsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular Engineering of Organophosphate Hydrolysis Activity from a Weak Promiscuous Lactonase Template

(2013) Monika M. Meier et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structural and Enzymatic Characterization of the Phosphotriesterase OPHC2 from Pseudomonas pseudoalcaligenes

(2013) Guillaume Gotthard et al.   PLoS One

Crystallization and preliminary X-ray diffraction analysis of the organophosphorus hydrolase OPHC2 fromPseudomonas pseudoalcaligenes

(2012) Guillaume Gotthard et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Enhancing the Promiscuous Phosphotriesterase Activity of a Thermostable Lactonase (GkaP) for the Efficient Degradation of Organophosphate Pesticides

(2012) Yu Zhang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Improving the thermostability of methyl parathion hydrolase from Ochrobactrum sp. M231 using a computationally aided method

(2012) Jian Tian et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Reconstructing a Missing Link in the Evolution of a Recently Diverged Phosphotriesterase by Active-Site Loop Remodeling

(2012) Livnat Afriat-Jurnou et al.   BIOCHEMISTRY

Catalytic Versatility and Backups in Enzyme Active Sites: The Case of Serum Paraoxonase 1

(2012) Moshe Ben-David et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural and Enzymatic characterization of the lactonase SisLac from Sulfolobus islandicus

(2012) Julien Hiblot et al.   PLoS One

Crystallization and preliminary crystallographic analysis of the phosphotriesterase-like lactonase fromGeobacillus kaustophilus

(2011) Baisong Zheng et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Divergence and Convergence in Enzyme Evolution: Parallel Evolution of Paraoxonases from Quorum-quenching Lactonases

(2011) Mikael Elias et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Purification and characterization of methyl parathion hydrolase from Burkholderia cepacia capable of degrading organophosphate insecticides

(2011) Anirut Ekkhunnatham et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Enzyme Promiscuity: A Mechanistic and Evolutionary Perspective

(2010) Olga Khersonsky and Dan S. Tawfik   Annual Review of Biochemistry

Hydrolysis of organophosphorus compounds by microbial enzymes

(2010) Casey M. Theriot et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Isolation of a methyl parathion-degrading strain Stenotrophomonas sp. SMSP-1 and cloning of the ophc2 gene

(2010) Yu-jia Shen et al.   BIODEGRADATION

Improving the promiscuous nerve agent hydrolase activity of a thermostable archaeal lactonase

(2010) Luigia Merone et al.   BIORESOURCE TECHNOLOGY

Phosphotriesterase variants with high methylphosphonatase activity and strong negative trade-off against phosphotriesters

(2010) Luis Briseño-Roa et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Functional Annotation and Three-Dimensional Structure of Dr0930 fromDeinococcus radiodurans, a Close Relative of Phosphotriesterase in the Amidohydrolase Superfamily†‡

(2009) Dao Feng Xiang et al.   BIOCHEMISTRY

Stability effects of mutations and protein evolvability

(2009) Nobuhiko Tokuriki et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Structure-Based and Random Mutagenesis Approaches Increase the Organophosphate-Degrading Activity of a Phosphotriesterase Homologue from Deinococcus radiodurans

(2009) Renda Hawwa et al.   JOURNAL OF MOLECULAR BIOLOGY

Mechanism of the Quorum-Quenching Lactonase (AiiA) fromBacillus thuringiensis. 1. Product-Bound Structures†‡

(2008) Dali Liu et al.   BIOCHEMISTRY

Structural Basis for Natural Lactonase and Promiscuous Phosphotriesterase Activities

(2008) Mikael Elias et al.   JOURNAL OF MOLECULAR BIOLOGY

Organophosphorus-degrading bacteria: ecology and industrial applications

(2008) Brajesh K. Singh   NATURE REVIEWS MICROBIOLOGY

How Protein Stability and New Functions Trade Off

(2008) Nobuhiko Tokuriki et al.   PLoS Computational Biology