Enhanced FK506 production inStreptomyces tsukubaensisby rational feeding strategies based on comparative metabolic profiling analysis

Evaluation and Optimization of Metabolome Sample Preparation Methods for Saccharomyces cerevisiae

(2013) Sooah Kim et al.   ANALYTICAL CHEMISTRY

Debottlenecking recombinant protein production in Bacillus megaterium under large-scale conditions-targeted precursor feeding designed from metabolomics

(2012) Claudia Korneli et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic profiling reveals growth related FAME productivity and quality of Chlorella sorokiniana with different inoculum sizes

(2012) Shuhuan Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolite profiling of CHO cells with different growth characteristics

(2012) Stefanie Dietmair et al.   BIOTECHNOLOGY AND BIOENGINEERING

LC-MS-based metabolic characterization of high monoclonal antibody-producing Chinese hamster ovary cells

(2012) William Pooi Kat Chong et al.   BIOTECHNOLOGY AND BIOENGINEERING

Combined in silico modeling and metabolomics analysis to characterize fed-batch CHO cell culture

(2012) Suresh Selvarasu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Metabolic responses to ethanol in Saccharomyces cerevisiae using a gas chromatography tandem mass spectrometry-based metabolomics approach

(2012) Hao Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolite profiling of sucrose effect on the metabolism of Melissa officinalis by gas chromatography-mass spectrometry

(2011) Sooah Kim et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A combined approach of classical mutagenesis and rational metabolic engineering improves rapamycin biosynthesis and provides insights into methylmalonyl-CoA precursor supply pathway in Streptomyces hygroscopicus ATCC 29253

(2011) Won Seok Jung et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Novel chemobiosynthetic approach for exclusive production of FK506

(2011) Gregor Kosec et al.   METABOLIC ENGINEERING

Comparative metabolic profiling of parental and inhibitors-tolerant yeasts during lignocellulosic ethanol fermentation

(2011) Ming-Zhu Ding et al.   Metabolomics

Metabolomics: from small molecules to big ideas

(2011) Monya Baker   NATURE METHODS

Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin involves a previously undescribed family of enzymes acting on chorismate

(2011) J. N. Andexer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origin of the Allyl Group in FK506 Biosynthesis

(2010) Dušan Goranovič et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biosynthesis of the Allylmalonyl-CoA Extender Unit for the FK506 Polyketide Synthase Proceeds through a Dedicated Polyketide Synthase and Facilitates the Mutasynthesis of Analogues

(2010) SangJoon Mo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Analytical platform for metabolome analysis of microbial cells using methyl chloroformate derivatization followed by gas chromatography–mass spectrometry

(2010) Kathleen F Smart et al.   Nature Protocols

Enhancement of bioenergy production and effluent quality by integrating optimized acidification with submerged anaerobic membrane bioreactor

(2009) Emma Jeong et al.   BIORESOURCE TECHNOLOGY

Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor

(2009) SangJoon Mo et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Regulation of tacrolimus production by altering primary source of carbons and amino acids

(2009) B.P. Singh et al.   LETTERS IN APPLIED MICROBIOLOGY

Metabolome profiling reveals adaptive evolution of Saccharomyces cerevisiae during repeated vacuum fermentations

(2009) Ming-Zhu Ding et al.   Metabolomics

Isolation and identification of a novel microorganism producing the immunosuppressant tacrolimus

(2008) Hyung Soo Kim et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING