Cis-suppression to arrest protein aggregation in mammalian cells

A revisited folding reporter for quantitative assay of protein misfolding and aggregation in mammalian cells

(2012) Simpson Gregoire et al.   Biotechnology Journal

A novel variant of human superoxide dismutase 1 harboring amyotrophic lateral sclerosis-associated and experimental mutations in metal-binding residues and free cysteines lacks toxicity in vivo

(2012) Mercedes Prudencio et al.   JOURNAL OF NEUROCHEMISTRY

Effects of culture temperature and pH on flag-tagged COMP angiopoietin-1 (FCA1) production from recombinant CHO cells: FCA1 aggregation

(2011) Su-Jeong Hwang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states

(2011) Mercedes Prudencio et al.   Molecular Neurodegeneration

Strategies for the Inhibition of Protein Aggregation in Human Diseases

(2010) Manuela Bartolini et al.   CHEMBIOCHEM

An examination of wild-type SOD1 in modulating the toxicity and aggregation of ALS-associated mutant SOD1

(2010) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Rate, molecular spectrum, and consequences of human mutation

(2010) M. Lynch   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Changes to Monomeric CuZn Superoxide Dismutase Caused by the Familial Amyotrophic Lateral Sclerosis-Associated Mutation A4V

(2009) Tom Schmidlin et al.   BIOPHYSICAL JOURNAL

Directed enzyme evolution: climbing fitness peaks one amino acid at a time

(2009) Cara A Tracewell et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Neuroprotective and neuritogenic activities of novel multimodal iron-chelating drugs in motor-neuron-like NSC-34 cells and transgenic mouse model of amyotrophic lateral sclerosis

(2009) Lana Kupershmidt et al.   FASEB JOURNAL

Adaptation to G93Asuperoxide dismutase 1 in a motor neuron cell line model of amyotrophic lateral sclerosis

(2009) Silvia Tartari et al.   FEBS Journal

Variation in aggregation propensities among ALS-associated variants of SOD1: Correlation to human disease

(2009) Mercedes Prudencio et al.   HUMAN MOLECULAR GENETICS

Understanding what determines the frequency and pattern of human germline mutations

(2009) Norman Arnheim et al.   NATURE REVIEWS GENETICS

Role of mutant SOD1 disulfide oxidation and aggregation in the pathogenesis of familial ALS

(2009) C. M. Karch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heterodimer formation of wild-type and amyotrophic lateral sclerosis-causing mutant Cu/Zn-superoxide dismutase induces toxicity independent of protein aggregation

(2008) Heidrun Witan et al.   HUMAN MOLECULAR GENETICS

Kemp elimination catalysts by computational enzyme design

(2008) Daniela Röthlisberger et al.   NATURE

Sequence determinants of protein aggregation in human VH domains

(2008) K. Dudgeon et al.   PROTEIN ENGINEERING DESIGN & SELECTION