An empirical modeling platform to evaluate the relative control discrete CHO cell synthetic processes exert over recombinant monoclonal antibody production process titer

Cell line-specific control of recombinant monoclonal antibody production by CHO cells

(2010) Peter M. O'Callaghan et al.   BIOTECHNOLOGY AND BIOENGINEERING

mRNA stability and antibody production in CHO cells: Improvement through gene optimization

(2010) Finn Hung et al.   Biotechnology Journal

Strategies for selecting Recombinant CHO cell lines for cGMP manufacturing: Realizing the potential in bioreactors

(2010) Alison J. Porter et al.   BIOTECHNOLOGY PROGRESS

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: Improving the efficiency of cell line generation

(2010) Alison J. Porter et al.   BIOTECHNOLOGY PROGRESS

Properties of the Proximate Parameter Tuning Regularization Algorithm

(2010) Martin Brown et al.   BULLETIN OF MATHEMATICAL BIOLOGY

Optimised mammalian expression through the coupling of codon adaptation with gene amplification: Maximum yields with minimum effort

(2010) Ekaterini Kotsopoulou et al.   JOURNAL OF BIOTECHNOLOGY

Identification of cellular genes critical to recombinant protein production using a Gaussia luciferase-based siRNA screening system

(2010) Teng Rhui Lwa et al.   JOURNAL OF BIOTECHNOLOGY

Accurate and objective copy number profiling using real-time quantitative PCR

(2010) Barbara D’haene et al.   METHODS

A Ubiquitous Chromatin Opening Element (UCOE) Confers Resistance to DNA Methylation–mediated Silencing of Lentiviral Vectors

(2010) Fang Zhang et al.   MOLECULAR THERAPY

The vesicle-trafficking protein munc18b increases the secretory capacity of mammalian cells

(2009) Ren-Wang Peng et al.   METABOLIC ENGINEERING

Molecular engineering of exocytic vesicle traffic enhances the productivity of Chinese hamster ovary cells

(2008) Ren-Wang Peng et al.   BIOTECHNOLOGY AND BIOENGINEERING

Systems biology towards life in silico: mathematics of the control of living cells

(2008) Hans V. Westerhoff et al.   JOURNAL OF MATHEMATICAL BIOLOGY

Control of translation initiation: a model-based analysis from limited experimental data

(2008) R. J Dimelow et al.   Journal of the Royal Society Interface

Proximate parameter tuning for biochemical networks with uncertain kinetic parameters

(2007) Stephen J. Wilkinson et al.   Molecular BioSystems

Effect of Increased Expression of Protein Disulfide Isomerase and Heavy Chain Binding Protein on Antibody Secretion in a Recombinant CHO Cell Line

(2005) Nicole Borth et al.   BIOTECHNOLOGY PROGRESS

On the Optimal Ratio of Heavy to Light Chain Genes for Efficient Recombinant Antibody Production by CHO Cells

(2005) Stefan Schlatter et al.   BIOTECHNOLOGY PROGRESS