Review
Engineering, Biomedical
Xu Chen, Qianping Guo, Wei Chen, Wanli Xie, Yunlong Wang, Miao Wang, Tianyan You, Guoqing Pan
Summary: This review highlights the bio-inspired structure colors of photonic crystal (PC) materials, emphasizing their advancement in biosensing, bio-probing, bio-screening, tissue engineering, and more. In addition, it discusses emerging applications based on functional materials and newly developed material engineering technologies, providing insight for developing next generation smart biomedical materials or devices.
ACTA BIOMATERIALIA
(2021)
Review
Materials Science, Multidisciplinary
Pooyan Makvandi, Aziz Maleki, Majid Shabani, Aaron R. J. Hutton, Melissa Kirkby, Rezvan Jamaledin, Tianxu Fang, Jiahuan He, Jesse Lee, Barbara Mazzolai, Ryan F. Donnelly, Franklin R. Tay, Guojun Chen, Virgilio Mattoli
Summary: This review discusses the biomimetic design, fabrication methods, and medical applications of bioinspired microneedles (BMNs), highlighting their potential in drug delivery, regenerative medicine, and other fields, as well as the future opportunities and challenges in clinical translation.
Review
Biology
Hossein Omidian, Renae L. Wilson, Niloofar Babanejad
Summary: Bioinspired polymers have become a promising field in biomaterials research, offering innovative solutions for various applications in biomedical engineering. This manuscript provides an overview of the advancements and potential of bioinspired polymers in tissue engineering, regenerative medicine, and biomedicine, discussing their role in enhancing mechanical properties, mimicking the extracellular matrix, incorporating hydrophobic particles for self-healing abilities, and improving stability. The manuscript also explores their applications in antibacterial properties, optical and sensing applications, cancer therapy, and wound healing, highlighting the transformative impact of bioinspired polymers in biomedical engineering and setting the stage for further research and development in the field.
Article
Mechanics
Masoud Shirzad, Mahdi Bodaghi, Dageon Oh, Myunggi Yi, Seung Yun Nam
Summary: According to the research, bioinspired auxetic structures with higher mechanical and physical properties can be achieved through the design and optimization of triangle auxetic structures. These structures have the characteristics of strong energy absorption and biofunctional benefits, making them promising for biomedical applications.
EUROPEAN JOURNAL OF MECHANICS A-SOLIDS
(2024)
Review
Chemistry, Physical
Shuyu Zhang, Guoshi Xu, Juan Wu, Xiao Liu, Yong Fan, Jun Chen, Gordon Wallace, Qi Gu
Summary: In recent years, significant advancements have been made in microphysiological constructs and systems (MPCs and MPSs), providing alternatives to animal models for drug discovery and personalized medicine. However, current approaches mainly focus on the in vitro recapitulation of the human anatomical structure and physiological-biochemical indices at a single or a few simple levels.
Review
Engineering, Multidisciplinary
Ajay Kumar Sahi, Shravanya Gundu, Pooja Kumari, Tomasz Klepka, Alina Sionkowska
Summary: Biomaterial research has revolutionized healthcare by developing programmable biomaterials through bio-inspired strategies. This review focuses on the structural and functional properties of silk material based scaffolds and explores their potential to unlock the body's regenerative potential.
Review
Nanoscience & Nanotechnology
Lantian Ma, Yuxu Sun, Qichao Cheng, Zhangze Yang, Jie Wang, Zongpu Xu, Mingying Yang, Yajun Shuai
Summary: Biomineralization is a process in which minerals nucleate and form specific crystal structures by regulating biomacromolecules. It occurs in bones and teeth, where collagen acts as a template for hydroxyapatite crystals. Silk proteins can also serve as templates for inorganic substances. Biomineralization enhances the properties of silk-based materials and has promising biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Parisa Pedram, Claudia Mazio, Giorgia Imparato, Paolo A. Netti, Aurelio Salerno
Summary: Porous microscaffolds play a crucial role in tissue engineering by controlling cell functions and guiding tissue formation. The study developed a new method to prepare porous PCL microscaffolds with a bioinspired structure, supporting the growth and biosynthesis of human dermal fibroblasts. By adjusting PEO concentration, coagulation bath temperature, and starting solution composition, the microscaffolds showed controllable diameter and interconnected pores, enabling the formation of hybrid tissue constructs in vitro.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Valeria Rahamim, Aharon Azagury
Summary: This review provides an overview of noninvasive biomimetic, bioinspired, and bioengineered drug delivery systems, highlighting their importance, applications, challenges, and future research directions. It discusses the various methods and strategies employed, inconsistencies in terminology, advantages and limitations of different delivery systems, and the unique physiology and hurdles in mass transport of related tissues. Additionally, it addresses the novelty and origins of these paradigms in noninvasive drug delivery and proposes potential areas for further research.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Review
Chemistry, Multidisciplinary
Hannah Haag, Paul D. Dalton, Veerle Bloemen
Summary: The regeneration and repair of complex structures in natural tissues remains a challenge, but recent advances in additive manufacturing have allowed for the development of more biomimetic scaffold designs. This review explores scaffold-based and scaffold-free approaches, as well as the use of fabrication technologies to produce complex implants. It highlights advanced scaffold designs and pre-programmed assembly methods, and discusses the application of hybridized manufacturing processes in tissue engineering.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Materials Science, Multidisciplinary
Zhiyu Zhou, Wentao Wang, Jianmin Wang, Hongshui Wang, Yi Xia, Wei Zhang, Yuxiao Lai, Xiao Lin, Yongcan Huang, Xuenong Zou, Martin J. Stoddart, Zhen Li, Wei Tian, Shaoyu Liu, Xinbao Wu, Manman Gao, Junhong Li, Lei Yang, Dafu Chen
Summary: Tissue engineering is a milestone in the developmental history of life science, but tissue-engineered biomaterials have not been widely used clinically. To overcome these challenges, a new approach has been proposed, focusing on the construction of organoid structures and function-oriented design.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Xiang Yao, Shengzhi Zou, Suna Fan, Qianqian Niu, Yaopeng Zhang
Summary: Silk fibroin is a promising biomaterial due to its exceptional properties, such as mechanical strength, biocompatibility, biodegradability, and availability. However, it is challenging to create materials with alternative formats from natural silk fibers. A bioinspired strategy that involves extracting desired building blocks of silk and then reconstructing them into functional regenerated silk fibroin (RSF) materials with controllable formats and structures has shown great potential. This approach allows for excellent processability and modifiability, making it suitable for various biomedical applications. Recent developments in extraction and reconstruction strategies have aimed to engineer RSF materials with properties similar to or surpassing those of naturally structured silk. This review discusses the different building blocks of silk used in the biomedical field, their effective extraction and reconstruction strategies, as well as recent advancements in the utilization of functional RSF biomaterials in areas such as cell-material interactions, soft tissue regeneration, and flexible bioelectronic devices. It also comprehensively discusses the potential opportunities and challenges associated with these bioinspired strategies and their usage, with the aim of providing valuable references for the design and modification of novel silk biomaterials and promoting the high-quality utilization of silk and other biopolymers.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Samira Malekmohammadi, Negar Sedghi Aminabad, Amin Sabzi, Amir Zarebkohan, Mehdi Razavi, Massoud Vosough, Mahdi Bodaghi, Hajar Maleki
Summary: Smart/stimuli-responsive hydrogels have diverse applications in the biomedical field, with the ability to change behavior in response to external stimuli; technologies like 4D bioprinting have expanded the possibilities of using smart hydrogels in various biomedical applications, driving innovation and development in the field.
Review
Engineering, Multidisciplinary
Thomas Ebbinghaus, Gregor Lang, Thomas Scheibel
Summary: Biomimicry applies principles of natural materials, processes, and structures to technology. This review discusses the two strategies of biomimicry: bottom-up and top-down approaches, using biomimetic polymer fibers and spinning techniques as examples. Bottom-up biomimicry helps gain fundamental knowledge on biological systems for technological advancements, while top-down biomimicry seeks solutions from natural role models. Examples like silk and collagen fibers, spider webs, animal hair, and tissue structures are presented. The review also provides an overview of biomimetic filter technologies, textiles, and tissue engineering.
BIOINSPIRATION & BIOMIMETICS
(2023)
Article
Multidisciplinary Sciences
Yasaman-Sadat Borghei, Saman Hosseinkhani, Mohammad Reza Ganjali
Summary: This review focuses on the basic physicochemical properties of plasmonic nanoparticles and their applications in biomedical and tissue engineering. It aims to provide a comprehensive and authoritative overview to the scientific community. The review introduces the fundamental characteristics of nanomaterials and illustrates their applications in the field through selected case studies.
JOURNAL OF ADVANCED RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Kambez H. Benam, Richard Novak, Janna Nawroth, Mariko Hirano-Kobayashi, Thomas C. Ferrante, Youngjae Choe, Rachelle Prantil-Baun, James C. Weaver, Anthony Bahinski, Kevin K. Parker, Donald E. Ingber
Article
Multidisciplinary Sciences
Janna C. Nawroth, Hanliang Guo, Eric Koch, Elizabeth A. C. Heath-Heckman, John C. Hermanson, Edward G. Ruby, John O. Dabiri, Eva Kanso, Margaret McFall-Ngai
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Review
Engineering, Biomedical
Janna Nawroth, Julia Rogal, Martin Weiss, Sara Y. Brucker, Peter Loskill
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Mechanics
Yang Ding, Janna C. Nawroth, Margaret J. McFall-Ngai, Eva Kanso
JOURNAL OF FLUID MECHANICS
(2014)
Article
Mechanics
Hanliang Guo, Janna Nawroth, Yang Ding, Eva Kanso
Article
Engineering, Multidisciplinary
M. M. Wilhelmus, J. Nawroth, B. Rallabandi, J. O. Dabiri
BIOINSPIRATION & BIOMIMETICS
(2020)
Article
Cell Biology
Kyung-Jin Jang, Monicah A. Otieno, Janey Ronxhi, Heng-Keang Lim, Lorna Ewart, Konstantia R. Kodella, Debora B. Petropolis, Gauri Kulkarni, Jonathan E. Rubins, David Conegliano, Janna Nawroth, Damir Simic, Wing Lam, Monica Singer, Erio Barale, Bhanu Singh, Manisha Sonee, Anthony J. Streeter, Carl Manthey, Barry Jones, Abhishek Srivastava, Linda C. Andersson, Dominic Williams, Hyoungshin Park, Riccardo Barrile, Josiah Sliz, Anna Herland Section, Suzzette Haney, Katia Karalis, Donald E. Ingber, Geraldine A. Hamilton
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Review
Biology
Janna C. Nawroth, Anne M. van der Does, Amy Ryan (Firth), Eva Kanso
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Article
Engineering, Biomedical
Richard Novak, Miles Ingram, Susan Marquez, Debarun Das, Aaron Delahanty, Anna Herland, Ben M. Maoz, Sauveur S. F. Jeanty, Mahadevabharath R. Somayaji, Morgan Burt, Elizabeth Calamari, Angeliki Chalkiadaki, Alexander Cho, Youngjae Choe, David Benson Chou, Michael Cronce, Stephanie Dauth, Toni Divic, Jose Fernandez-Alcon, Thomas Ferrante, John Ferrier, Edward A. FitzGerald, Rachel Fleming, Sasan Jalili-Firoozinezhad, Thomas Grevesse, Josue A. Goss, Tiama Hamkins-Indik, Olivier Henry, Chris Hinojosa, Tessa Huffstater, Kyung-Jin Jang, Ville Kujala, Lian Leng, Robert Mannix, Yuka Milton, Janna Nawroth, Bret A. Nestor, Carlos F. Ng, Blakely O'Connor, Tae-Eun Park, Henry Sanchez, Josiah Sliz, Alexandra Sontheimer-Phelps, Ben Swenor, Guy Thompson, George J. Touloumes, Zachary Tranchemontagne, Norman Wen, Moran Yadid, Anthony Bahinski, Geraldine A. Hamilton, Daniel Levner, Oren Levy, Andrzej Przekwas, Rachelle Prantil-Baun, Kevin K. Parker, Donald E. Ingber
NATURE BIOMEDICAL ENGINEERING
(2020)
Article
Biochemistry & Molecular Biology
Janna C. Nawroth, Carolina Lucchesi, Deion Cheng, Abhishek Shukla, Justin Ngyuen, Tanvi Shroff, Antonio Varone, Katia Karalis, Hyun-Hee Lee, Stephen Alves, Geraldine A. Hamilton, Michael Salmon, Remi Villenave
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2020)
Article
Cell Biology
Katrina A. A. Gundlach, Janna Nawroth, Eva Kanso, Farzana Nasrin, Edward G. G. Ruby, Margaret McFall-Ngai
Summary: The Hawaiian bobtail squid rapidly responds to bacteria in the surrounding seawater after hatching, increasing the efficiency of Vibrio fischeri colonization in host tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Laura von Schledorn, David Puertollano Martin, Nicole Cleve, Janina Zoellner, Doris Roth, Ben Ole Staar, Jan Hegermann, Felix C. Ringshausen, Janna Nawroth, Ulrich Martin, Ruth Olmer
Summary: Primary ciliary dyskinesia (PCD) is a rare genetic disorder that affects the function of motile cilia in the respiratory tract, leading to chronic inflammation and lung damage. Current treatment options for PCD are only symptomatic, highlighting the need for curative therapies. In this study, researchers developed an in vitro model using human induced pluripotent stem cells (hiPSC) to recapitulate the diseased phenotype of PCD at the molecular, structural, and functional levels.
Article
Biology
Janna C. Nawroth, Christoph Giez, Alexander Klimovich, Eva Kanso, Thomas C. G. Bosch
Summary: This study provides evidence that spontaneous contractions of the freshwater polyp Hydra's body walls enhance the transport of chemical compounds between the tissue surface and symbiotic bacteria. The frequency of these contractions affects the composition of the colonizing microbiota. The findings suggest that spontaneous body wall contractions play a crucial role in shaping host-microbe associations and the spatial distribution of colonizing microbes.
Article
Physics, Fluids & Plasmas
Alexander P. Hoover, Joost Daniels, Janna C. Nawroth, Kakani Katija
Summary: The study investigates the kinematics and fluid transport of the giant larvacean's beating tail, using deep sea robots, advanced imaging tools, and numerical modeling. The results show that muscle activation in two-thirds of the tail's length generates a greater average downstream flow speed than other designs, indicating that the larvacean tail's active and passive material properties are tuned for efficient fluid transport.
Article
Engineering, Biomedical
Janna C. Nawroth, Lisa L. Scudder, Ryan T. Halvorson, Jason Tresback, John P. Ferrier, Sean P. Sheehy, Alex Cho, Suraj Kannan, Ilona Sunyovszki, Josue A. Goss, Patrick H. Campbell, Kevin Kit Parker
Review
Biotechnology & Applied Microbiology
Zhi-Min Zhao, Zhi-Hua Liu, Tongtong Zhang, Rongqian Meng, Zhiqun Gong, Yibing Li, Jing Hu, Arthur J. Ragauskas, Bing-Zhi Li, Ying-Jin Yuan
Summary: Bioconversion of bioresources/wastes using Rhodococcus is a promising approach for producing lipid-derived bioproducts. However, bioconversion involves living cells and is a complex system that requires further understanding. This review highlights the potential of Rhodococcus for producing lipids from various wastes and presents genetic modifications using emerging tools for promoting bioconversion. Additionally, strategies for enhancing the bioaccessibility of lignin and its derived aromatics and synthesizing biodiesel and aviation fuels from lignin and lipids are discussed. The synergistic modification of microbial strains, substrates, and fermentation processes is proposed for sustainable biological lignin valorization.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Maddy L. Newby, Joel D. Allen, Max Crispin
Summary: A key aspect of successful viral vaccine design is the elicitation of neutralizing antibodies targeting viral attachment and fusion glycoproteins. Glycosylation can influence the antigenicity and immunogenicity of vaccines, with native-like glycosylation potentially enhancing immunogenicity. Understanding viral glycosylation can guide the development of future vaccines in various enveloped viruses.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Uganeeswary Suparmaniam, Man Kee Lam, Jun Wei Lim, Inn Shi Tan, Bridgid Lai Fui Chin, Siew Hoong Shuit, Steven Lim, Yean Ling Pang, Peck Loo Kiew
Summary: Microalgae have the ability to synthesize high-value phytochemicals, and subjecting them to abiotic stress can enhance the accumulation of valuable metabolites within their cells. This study explores the effects of manipulating abiotic stress on microalgae yields and discusses approaches to increase HVPCs production using abiotic stress.
BIOTECHNOLOGY ADVANCES
(2024)
Review
Biotechnology & Applied Microbiology
Pei Zhou, Cong Gao, Wei Song, Wanqing Wei, Jing Wu, Liming Liu, Xiulai Chen
Summary: The engineering status of protein is crucial for the efficient bioproduction in microbial cell factories. Strategies such as protein engineering, protein modification, and protein assembly can effectively modify the protein status and enhance production efficiency.
BIOTECHNOLOGY ADVANCES
(2024)
