2A to the Fore – Research, Technology and Applications

Dissection of a co-translational nascent chain separation event

(2008) Victoria A. Doronina et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Local secretion of anti-CTLA-4 enhances the therapeutic efficacy of a cancer immunotherapy with reduced evidence of systemic autoimmunity

(2008) Andrew D. Simmons et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Imaging Stem Cell Implant for Cellular-Based Therapies

(2008) Zhenghong Lee et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells

(2008) D P Hart et al.   GENE THERAPY

Development of optimal bicistronic lentiviral vectors facilitates high-level TCR gene expression and robust tumor cell recognition

(2008) S Yang et al.   GENE THERAPY

Expression of heterologous genes in oncolytic adenoviruses using picornaviral 2A sequences that trigger ribosome skipping

(2008) G. M. Funston et al.   JOURNAL OF GENERAL VIROLOGY

Occurrence, function and evolutionary origins of '2A-like' sequences in virus genomes

(2008) G. A. Luke et al.   JOURNAL OF GENERAL VIROLOGY

New insights into internal ribosome entry site elements relevant for viral gene expression

(2008) E. Martinez-Salas et al.   JOURNAL OF GENERAL VIROLOGY

Enhanced functionality of T cell receptor-redirected T cells is defined by the transgene cassette

(2008) Matthias Leisegang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Site-Specific Release of Nascent Chains from Ribosomes at a Sense Codon

(2008) V. A. Doronina et al.   MOLECULAR AND CELLULAR BIOLOGY

Foot and Mouth's Achilles' heel?

(2008) John F Atkins et al.   NATURE BIOTECHNOLOGY

CD3 ITAMs count!

(2008) Bernard Malissen   NATURE IMMUNOLOGY

Scalable signaling mediated by T cell antigen receptor–CD3 ITAMs ensures effective negative selection and prevents autoimmunity

(2008) Jeff Holst et al.   NATURE IMMUNOLOGY

Reprogramming of murine and human somatic cells using a single polycistronic vector

(2008) B. W. Carey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induced Pluripotent Stem Cells Generated Without Viral Integration

(2008) M. Stadtfeld et al.   SCIENCE

Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors

(2008) K. Okita et al.   SCIENCE