Journal
BIOTECHNOLOGY & BIOTECHNOLOGICAL EQUIPMENT
Volume 25, Issue 4, Pages 2668-2671Publisher
TAYLOR & FRANCIS LTD
DOI: 10.5504/BBEQ.2011.0099
Keywords
5-HT; acute toxicity; antidepressant activity; Hypericum aucheri; mangiferin; MAO activity
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Antidepressive effect of mangiferin isolated from Hypericum aucheri Jaub. et Spach (Clusiaceae) was studied. The purpose of this research was to assess the effects of mangiferin in the forced swimming test (PST) and to investigate whether inhibition of monoamine oxidase (MAO) activity contributes to the antidepressant-like effects of mangiferin. Acute toxicity of mangiferin was determined in male mice after p.o. (4984 mg/kg b.w.) and i.p. (490 mg/kg b.w) administration. Single (dose ranging between 62.5 and 500 mg/kg b.w.) and repeated (250 mg/kg for 7 or 14 days) per oral treatment of mice with mangiferin decreased the immobilization lime in FST. The antidepressant activity of mangiferin increased in a dose-dependent manner up to 250 mg/kg b.w, but no increase was observed thereafter Mangiferin inhibited MAO(A) (IC50 is 4.1 x 10(-4)) and MAO(B) (10(50) is approximate to 10(-3) M) activity in rat liver mitochondria. Our findings demonstrated that mangiferin exerted antidepressant-like effect in behavioral paradigms of despair possibly by modulating brain biogenic amities (norepinephrine and serotonin).
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