Journal
BIOTECHNIC & HISTOCHEMISTRY
Volume 87, Issue 3, Pages 179-186Publisher
INFORMA HEALTHCARE
DOI: 10.3109/10520295.2011.592151
Keywords
ADRBK2; adrenergic receptors; beta 2-adrenergic receptor; norepinephrine; oral squamous cell carcinoma
Categories
Ask authors/readers for more resources
The beta 2-adrenergic receptor is most frequently involved in carcinogenic processes. Earlier studies have established a relation between the beta 2-adrenergic receptor and various characteristics of cancer including cell proliferation, apoptosis, chemotaxis, metastasis, tumor growth and angiogenesis. Our goal was to determine differential expression of the genes involved in adrenergic receptors using DNA microarrays and to confirm their under-or overexpression using real-time quantitative PCR. Five of the nine genes investigated showed significantly altered expression levels in tumor cells (p < 0.05). The gene product with the highest Z-score (restrictive statistical technique for selection of appropriate genes to study) was ADRBK2. Significantly, most of the overexpressed genes were related to beta-adrenergic receptors. Real-time PCR analysis confirmed the up regulation observed in the microarrays, which indicated overexpression in 100% of the tumors. In oral squamous cell carcinomas, malignant cells and surrounding tissue overexpress the ADRBK2 gene.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available