Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1416, Issue -, Pages 74-82Publisher
ELSEVIER
DOI: 10.1016/j.chroma.2015.09.011
Keywords
Polyhedral oligomericsilsesquioxane (POSS); Thiol-epoxy click polymerization; Hybrid monolith; Capillary liquid chromatography
Funding
- China State Key Basic Research Program [2013CB911203, 2012CB910601]
- National Natural Sciences Foundation of China [21235006, 21175133]
- Creative Research Group Project of NSFC [21321064]
- Knowledge Innovation program of DICP
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Two kinds of hybrid monoliths were first prepared via thiol-epoxy click polymerization using a multi-epoxy monomer, octaglycidyldimethylsilyl POSS (FOSS-epoxy), and two multi-thiols, trimethylolpropanetris(3-mercaptopropionate) (TPTM) and pentaerythritoltetrakis(3-mercaptopropionate) (PTM), respectively, as the precursors. The resulting two hybrid monoliths (assigned as POSS-epoxy-TPTM and POSS-epoxy-PTM) not only possessed high thermal, mechanical and chemical stabilities, but also exhibited well-controlled 3D skeletal microstructure and high efficiency in capillary liquid chromatography (cLC) separation of small molecules. The highest column efficiency reached 182,700 N/m (for butylbenzene) on the monolith POSS-epoxy-PTM at the velocity of 0.75 mm/s. Furthermore, the hybrid monolith POSS-epoxy-PTM was successfully applied for cLC separations of various samples, not only standard compounds such as alkylbenzenes, PAHs, phenols and dipeptides, as well as intact proteins, but also complex samples of EPA 610 and BSA digest. (C) 2015 Elsevier B.V. All rights reserved.
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