Adaptive enrichment designs for clinical trials

A Robust Method for Estimating Optimal Treatment Regimes

(2012) Baqun Zhang et al.   BIOMETRICS

Optimizing randomized trial designs to distinguish which subpopulations benefit from treatment

(2011) M. Rosenblum et al.   BIOMETRIKA

Adaptive Clinical Trial Designs for Simultaneous Testing of Matched Diagnostics and Therapeutics

(2011) H. I. Scher et al.   CLINICAL CANCER RESEARCH

The BATTLE Trial: Personalizing Therapy for Lung Cancer

(2011) Edward S. Kim et al.   Cancer Discovery

A threshold sample-enrichment approach in a clinical trial with heterogeneous subpopulations

(2010) Aiyi Liu et al.   Clinical Trials

Clinical Trial Designs for Predictive Biomarker Validation: Theoretical Considerations and Practical Challenges

(2009) Sumithra J. Mandrekar et al.   JOURNAL OF CLINICAL ONCOLOGY

The cancer biomarker problem

(2008) Charles L. Sawyers   NATURE