Article
Chemistry, Analytical
Yanyan Niu, Yuxue Chen, Xiaoping Zhang, Hui Xie, Guiling Luo, Wei Sun
Summary: This study developed a PEC aptasensor for quantitative analysis of Cd(II) by changing the sensing interface structure to amplify the detection signal. The sensor showed high sensitivity with a detection limit of 1.1 x 10-11 mol/L and was successfully used for water sample detection.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Min Zhou, Hui Huang, Xiao Zhao, Zhong Cheng, Wenfang Deng, Yueming Tan, Qingji Xie
Summary: This study reports a novel signaling strategy for photoelectrochemical (PEC) immunoassays based on the electro-Fenton degradation of liposomes. By degrading the liposomes, the photogenerated holes can be effectively scavenged by ascorbic acid, resulting in a sensitive signal for the target in PEC immunoassays.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Xin Zhang, Ling-Hua Jin, Yan-Yan Li, Zi-Zhen Xiao, Yu Feng, Ying-Wu Lin, Ye Zhang
Summary: A self-powered photoelectrochemical (PEC) immunosensor based on Cu3SnS4 nanoflower is constructed for the ultra-sensitive and portable real-time detection of human cytochrome c (Cyt c). The immunosensor shows good reproducibility, high specificity, good storage stability, and excellent detection capability of Cyt c in clinical serum samples. The detection range is from 1 fM to 1000 nM, with an ultra-sensitive detection limit of 0.35 fM.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Electrochemistry
Yun Chen, Li Xu, Jintao Dong, Pengcheng Yan, Feng Chen, Junchao Qian, Henan Li
Summary: A high-performance and selective PEC aptasensor using NiFe LDH/g-CN heterojunction has been developed for efficient detection of residual OFL. The heterojunction structure enhances close contact between materials and accelerates electron transfer, leading to increased photocurrent signal and improved performance for monitoring OFL in real samples.
ELECTROCHIMICA ACTA
(2021)
Article
Biophysics
Xilian Ouyang, Chengyang Feng, Lin Tang, Xu Zhu, Bo Peng, Xinyang Fan, Yibo Liao, Zheping Zhou, Ziling Zhang
Summary: This study reports a novel photoelectrode by immobilizing alpha-Fe2O3 nanoparticles/defect-rich carbon nitride onto flexible carbon fiber textile, which provides larger specific surface area and higher mechanical strength for faster reaction and signal amplification. The photoelectrode was used to construct a flexible PEC aptasensor for ultrasensitive detection of penbritin, demonstrating wide linear range, low detection limit, and high stability. The design principle is applicable to other photoelectric sensing systems, paving the way for portable environmental analysis and field diagnostics equipment.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Analytical
Yun Chen, Li Xu, Mengying Yang, Yunfan Jia, Yuting Yan, Junchao Qian, Feng Chen, Henan Li
Summary: A photoelectrochemical aptasensor based on CoAl LDH/g-C3N4 has been developed for the determination of OFL, showing remarkable PEC performance, wide linearity range, low detection limit, anti-inference capability, and feasibility for OFL assay in actual water samples. This design can significantly amplify the photocurrent signal, indicating potential for PEC analysis and environmental pollutants detection.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Analytical
Xin Li, Yishuang Li, Yuxin Wang, Pan Liang, Guosong Lai
Summary: A distance-regulated PEC sensor was developed for multiplex detection by using an i-Motif sequence as the signal transduction unit. By dynamically regulating the distance between the functional sequence and the electrode material, the photogenerated electrons on the sensor's surface were directionally transferred. The PEC sensor with dual signal output modes was successfully applied to detect two virus nucleic acid sequences.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yun Chen, Pengcheng Yan, Guifen Lu, Jianping Chen, Feng Chen, Li Xu
Summary: A self-powered photoelectrochemical chloramphenicol aptasensor based on AgBr/BiOBr composites has been developed, featuring a wide linear detection range, low detection limit, high anti-interference, and the capability to detect real milk and river water samples. The use of AgBr-based photoelectrochemical active materials in this platform is expected to be beneficial for monitoring environmental pollutants.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Analytical
Lu-Ying Wang, Jing-Shuai Chen, Xing-Pei Liu, Chang-Jie Mao, Bao-Kang Jin
Summary: In this paper, an ultrasensitive photoelectrochemical aptasensor based on amplified signal strategy and competitive mechanism for ochratoxin A (OTA) detection was developed. The prepared photoactive composite material (BiFeO3/Bi2S3) possessed excellent separation ability of photogenerated electron-hole pair and effectively inhibited the recombination of hole and pair, resulting in significantly enhanced photocurrent intensity. The amplified signal strategy was achieved by adding methylene blue (MB), which facilitated electron transfer and improved the photoelectric conversion efficiency. Under optimal conditions, the aptasensor exhibited a wide linear relationship range from 10^5 to 10^13 g/mL and a low detection limit of 0.0135 fg/mL (3s/S). Simultaneously, the proposed photoelectrochemical aptasensor also showed excellent accuracy, stability, precision, and selectivity.
Article
Chemistry, Analytical
Mengying Yang, Yun Chen, Pengcheng Yan, Jintao Dong, Wei Duan, Li Xu, Henan Li
Summary: A photoelectrochemical aptasensor was developed using Bi24O31Cl10/BiOCl heterojunction as the photoelectric active material to detect trace ciprofloxacin in water. The sensor showed high sensitivity, a wide detection range, and a low detection limit due to the combination between aptamer and ciprofloxacin. The PEC aptasensor exhibited good selectivity and reproducibility for the determination of ciprofloxacin in water.
Article
Chemistry, Multidisciplinary
Zhihua Liu, Jinzhe Li, Jianguo Zhou
Summary: This study demonstrates the enhancement of photoelectrochemical activity of BiFeO3 photoelectrodes through ion modification, which increases visible light absorption and active area, leading to improved PEC water splitting performance.
NEW JOURNAL OF CHEMISTRY
(2024)
Article
Engineering, Environmental
Mengying Yang, Yunfan Jia, Yun Chen, Pengcheng Yan, Li Xu, Junchao Qian, Feng Chen, Henan Li
Summary: In this study, a PEC aptasensor was designed and constructed using g-C3N4/Bi24O31Cl10 heterojunction as the photoelectric active material for the sensitive detection of enrofloxacin (ENR) antibiotic. The formation of the heterojunction enhanced the photocurrent response and improved the sensitivity of the sensor. The ENR-aptamer complex was used as the specific recognition element, providing excellent selectivity for the sensor. The developed sensor demonstrated excellent sensitivity and selectivity for ENR detection, making it potentially useful for real sample analysis.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2022)
Article
Chemistry, Analytical
Zhichong Qi, Pengcheng Yan, Junchao Qian, Linhua Zhu, Henan Li, Li Xu
Summary: In this study, a photoelectrochemical (PEC) aptasensor based on graphitic carbon nitride (g-C3N4) loaded by CoN nanoparticles was proposed for sensitive detection of Atrazine (ATZ). The aptasensor showed excellent stability, selectivity, and anti-jamming capability, making it a practical technology for selective and sensitive detection of ATZ in the aquatic environment.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Analytical
Yuru Shen, Chenglong Sun, Mingjian Chen, Yun Du, Jun Cheng, Yunlong Li, Qingji Xie
Summary: A new BiVO4-carboxylated graphene (cG)-WO3 Z-scheme heterojunction was constructed for determination of oxytetracycline (OTC). The photocurrent on the BiVO4-cG-WO3/FTO photoelectrode was 4.4 times higher than that on the control BiVO4-WO3/FTO photoelectrode due to the energy level match and charge separation. By attaching an amino-functionalized OTC aptamer and hexaammonium ruthenium(III) to the BiVO4-cG-WO3/FTO photoelectrode, the photocurrent response to OTC binding was increased.
Article
Chemistry, Analytical
Xiaoqi Chen, Zhiqing Yang, Luchen Ai, Shuang Zhou, Hai Fan, Shiyun Ai
Summary: A signal-off photoelectrochemical aptasensor for pathogenic bacteria detection was developed using graphite-like carbon nitride decorated with NiO. The sensor demonstrated excellent specificity and sensitivity for S. aureus, offering a simple strategy for constructing point-of-care testing aptasensors for bacterial analysis.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)