Journal
BIOSENSORS & BIOELECTRONICS
Volume 119, Issue -, Pages 63-69Publisher
ELSEVIER ADVANCED TECHNOLOGY
DOI: 10.1016/j.bios.2018.07.068
Keywords
Photoelectrochemistry; Cathodic photocurrent; Thrombin; Pb2+
Categories
Funding
- National Natural Science Foundation of China, China [21775080]
- Key Research and Development Project of Shandong Province, China [2017GSF221004, 2018GSF121010]
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Novel cathodic photoelectrochemical (PEC) aptasensors for sensitive and selective determination of thrombin and Pb2+ were developed based on a new dual-signal amplification strategy. The presence of gold nanoparticles (AuNPs) could quench the PEC signal of bismuth oxyiodide (BiOI). At the same time, the redox moiety G-quadruplex/hemin or ferrocene (Fc) was found to enhance the PEC signal of BiOI. So, in the presence of thrombin or Pb2+, the interaction between target and the aptamer resulted in the releasement of the AuNPs, as well as shorter distance between the redox moiety and the electrode surface. Hence dual-enhanced cathodic PEC biosensor strategy was realized. Under the optimized conditions, the detection limits of thrombin and Pb2+ were 17.3 fM and 3.16 pM, respectively with good selectivity. At the same time, the PEC performance of redox moiety G-quadruplex/hemin and Fc was compared.
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