Article
Biotechnology & Applied Microbiology
Baojuan Wang, Jinxin Fang, Huiliang Tang, Shan Lu, Yan Chen, Xiaoqi Yang, Yuezhen He
Summary: Protein-protected metal nanomaterials, specifically cellulase protected fluorescent gold nanoclusters (Cel-Au NCs), have been developed as a promising tool for biosensing and bioimaging. These nanoclusters exhibit red fluorescence and can be used as a biosensor for specific detection of ascorbic acid (AA) and labeling of bacteria. The Cel-Au NCs show satisfactory linearity and a low detection limit, making them an excellent fluorescent bioprobe for medical diagnosis and human health maintenance.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Chemical
Liam Yourston, Polikron Dhoqina, Nolan Marshall, Rujani Mahmud, Ethen Kuether, Alexey Viktorovich Krasnoslobodtsev
Summary: Atomically precise silver nanoclusters (AgNCs) are nanostructures consisting of only a few silver atoms. When combined with cytosine-rich single-stranded oligonucleotides, they form DNA-templated silver nanoclusters (DNA-AgNCs) that exhibit highly luminescent and reproducible fluorescent properties. By utilizing nucleic acids as templates, AgNCs can be engineered to extend optical activity, allowing for the rational design of their properties, such as in biosensors for detecting heavy metals like Hg2+.
Article
Chemistry, Multidisciplinary
Akhilesh Kumar Gupta, Alexey V. Krasnoslobodtsev
Summary: In this study, a fluorescent/electrochemical dual-mode self-powered biosensor was developed using DNA-templated silver nanoclusters (AgNCs@DNA) for advanced biosensing. AgNCs@DNA showed advantages as an optical probe and was successfully applied for glucose detection. The biosensor exhibited low-level limits of detection, simultaneous utilization of different readout strategies, and a self-powered design.
Article
Spectroscopy
Lan Li, Meiling Fu, Deyuan Yang, Yifeng Tu, Jilin Yan
Summary: A sensitive fluorescence detection method for glutathione was developed using glutathione-stabilized copper nanoclusters. The interaction between CuNCs and p-benzoquinone provided fluorescence enhancement for glutathione measurement. The assay showed high sensitivity and selectivity, with successful application in real sample measurements.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Review
Chemistry, Analytical
Donato Calabria, Martina Zangheri, Seyedeh Rojin Shariati Pour, Ilaria Trozzi, Andrea Pace, Elisa Lazzarini, Maria Maddalena Calabretta, Mara Mirasoli, Massimo Guardigli
Summary: The presence of hidden allergens in food products has led to the urgent need for rapid and reliable analytical methods. Portable biosensors based on immunoassays and aptamers have shown promise as alternative detection methods for food allergens.
Article
Chemistry, Analytical
Zheng Wei Wong, Siu Yee New
Summary: A fluorescence biosensor based on hybridisation chain reaction amplification coupled with silver nanoclusters has been developed for nucleic acid detection, providing a reliable and low risk method for detecting target DNA.
Article
Chemistry, Analytical
Xin Zheng, Qiumeng Chen, Zhixiao Zhang, Zhaoli Wang, Zhengjun Gong
Summary: Researchers have designed a fluorescence-enhanced copper nanocluster based on tannic acid templating, which can be used as a new fluorescent probe for tetracycline detection. The modified probe showed good linearity and low detection limit, and demonstrated promising application prospects in actual water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Yumei Zhang, Liyun Ding, Haowen Zhang, Pan Wang, Haijun Li
Summary: Acetylcholine is an essential neurotransmitter in the diagnosis and treatment of neurological diseases. A new optical fiber biosensor based on N-CQDs/AchE compound has been developed, which shows promising potential in detecting acetylcholine concentration accurately.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Chemistry, Applied
Azam Bagheri Pebdeni, Maryam Mousavizadegan, Morteza Hosseini
Summary: The proposed dual detection sensor combines aptamer and antibiotic for effective recognition and quantification of Staphylococcus aureus. The sensor showed high specificity in detecting S. aureus using CuNCs, with potential applications for monitoring pathogenic bacteria.
Article
Chemistry, Analytical
Shao-Hua Wen, Hengyuan Zhang, Sha Yu, Junping Ma, Jun-Jie Zhu, Yuanzhen Zhou
Summary: A novel COF/MB@MnO2 composite with abundant signal loading, specific recognition unit, and robust oxidase-like activity was successfully prepared for the detection of organophosphorus pesticides. The composite served as a dual-mode sensing platform, allowing electrochemical and photothermal measurements, and exhibited excellent performance in detecting OPs in complex environmental and food samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Guowen Li, Xiufang Huang, Chifang Peng, Fengxia Sun
Summary: Through optimizing the synthesis of silver nanoclusters (Ag NCs) using DNA templates, it was found that the fluorescence intensity of T base-extended DNA-templated Ag NCs was more than three times higher than C-riched DNA-templated Ag NCs. A turn-off fluorescence sensor based on the brightest DNA-Ag NCs was constructed for the sensitive detection of dimethoate, ethion, and phorate in lake water samples.
Article
Spectroscopy
Zhiqiang Chen, Wenchao Lv, Chen Yang, Meiling Ping, FengFu Fu
Summary: Free copper ions have critical toxicity to cells, and it is important to develop sensitive monitoring methods. This study designed a ssDNA sequence for synthesizing silver nanoclusters and demonstrated that Cu+/Cu2+ can induce their aggregation and greatly enhance fluorescence emission. Based on this, a fluorescent sensing platform was developed for the detection of Cu+/Cu2+ in biological samples and intracellular imaging, with advantages of rapid detection, simplicity, high sensitivity, good cell permeability, and biocompatibility.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2022)
Article
Chemistry, Analytical
Ning Lian, Yaheng Zhang, Dan Liu, Jianghong Tang, Haiyan Wu
Summary: Copper nanoclusters were synthesized using excess cysteine and successfully used to detect quinolones in a cost-effective, highly selective, and sensitive sensor. The sensor showed strong potential in detecting target fluorescent substances in tablets and human urine with a wide linear range and low detection limits.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Analytical
Yongjun Bian, Mengwei Li, Zhaojie Wu, Jian Weng, Ru Zeng, Liping Sun
Summary: Researchers have developed an ultrasensitive fluorescent biosensor using sporopollenin capsules as a substrate for isothermal amplification. This biosensor can detect miRNA with a low detection limit and a wide linear range, and it shows high selectivity and minimal interference from serum proteins.
Article
Chemistry, Analytical
Hongyu Chen, Yuan Chang, Ran Wei, Pengcheng Zhang
Summary: AuNCs@ZnGlu-MOFs nanomaterials with high quantum yield and water stability were synthesized using a one-pot approach. The unique spatial structure of the material improved selectivity and enabled it to be used as a selective fluorescence probe for detecting H2O2 and H2O2-related substances.
ANALYTICAL METHODS
(2022)
Article
Engineering, Electrical & Electronic
Weipeng Gao, Hongchang Li, Yi Tang
Summary: This paper proposes a method to improve the power transfer capacity of wireless power transfer systems by optimizing the geometric distribution of the coil wire loops. The method reduces computational complexity and effectiveness is demonstrated through design examples and experiments.
JOURNAL OF POWER ELECTRONICS
(2022)
Article
Computer Science, Software Engineering
Hongchang Li, Fang Gao, GuoCai Zuo
Summary: This paper researches the autonomous path tracking of agricultural machinery through the agricultural machinery kinematics model and the related theory of deep reinforcement learning, and proves that agricultural machinery can achieve better automatic control after empirical learning, which is of great significance for promoting the automatic navigation and control of agricultural machinery.
SCIENTIFIC PROGRAMMING
(2022)
Article
Green & Sustainable Science & Technology
Lijuan Zuo, Hongchang Li, Hongyan Gao, Man Zhu
Summary: This study used the DEA-Malmquist model to evaluate the efficiency of science and technology investment in 30 internet-listed companies in China. It found that technology investment can improve the innovation efficiency of internet companies, although there is heterogeneity among different companies. The study also provides path suggestions for the in-depth development of digitalization.
Article
Biochemistry & Molecular Biology
Qi-Zhen Yang, Hong-Chang Li, Zhong-Bao Guo, Yong-Zhi Liao, Rui-Xue Liu, Yan-Cheng Liu, Hong Liang
Summary: DA-Cu exhibits significant antibacterial activity against Flavobacterium columnar, the bacteria causing gill-rot disease in fish. Moreover, the therapeutic effect of DA-Cu at a lower dosage is superior to DA and the positive control Sanhuang San.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2022)
Article
Chemistry, Analytical
Xiaoyan Sun, Ruizhi Wen, Ruimei Zhang, Yuxin Guo, Hongchang Li, Yong-Ill Lee
Summary: This work developed a smartphone-assisted ratiometric-sensing platform for detecting copper ions (Cu2+). The platform utilized a ratiometric fluorescence sensor to measure the linear relationship between fluorescence intensity ratio and Cu2+ concentration. Fluorescence images captured with a smartphone were analyzed using desktop software, eliminating the need for expensive equipment and complex operations.
MICROCHEMICAL JOURNAL
(2022)
Article
Cell Biology
Hongchang Li, Chaonan Li, Wenjing Zhai, Xin Zhang, Lei Li, Bo Wu, Biyue Yu, Pengfei Zhang, Jie Li, Chun-Ping Cui, Lingqiang Zhang
Summary: Autophagy is essential for neonatal energy homeostasis and survival. The deubiquitylase ubiquitin-specific peptidase 10 (USP10) destabilizes TP53 to regulate neonatal autophagy and viability.
Article
Polymer Science
Jishu Zhang, Yonggang Li, Huawei Wu, Chunhong Wang, Kushairi Mohd Salleh, Hongchang Li, Sarani Zakaria
Summary: This study developed a safe and advanced antibacterial material of electrospun microfiber membranes (MFMs) for wound dressings. By investigating different material combinations and treatment methods, the best quality of MFMs suitable for specific applications was obtained. The results showed that the addition of berberine significantly improved the antibacterial and mechanical properties of the MFMs, making them a potential low-cost and low side effects antibacterial wound dressing substrate.
Review
Pharmacology & Pharmacy
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Summary: This review focuses on the role of TRPA1 channel in fibroblasts, exploring its interactions with inflammatory factors and its different functions in the fibrosis process in different organs. The aim of this review is to describe the function of TRP channels in controlling fibrosis through fibroblasts in various inflammatory and immune-mediated diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Hongchang Li, Xianhao Sun, Jindong Li, Weiyan Liu, Gaofeng Pan, Anwei Mao, Jiazhe Liu, Qing Zhang, Longhua Rao, Xiaofeng Xie, Xia Sheng
Summary: This study found that hypoxia induces docetaxel resistance in triple-negative breast cancer (TNBC) by decreasing miR-494 levels. Modulating miR-494 expression can alter the sensitivity of TNBC cells to docetaxel under hypoxic conditions. The HIF-1 alpha/miR-494/Survivin signaling pathway is active in primary human TNBC, and miR-494 expression negatively correlates with HIF1 alpha and survivin expression. Targeting this pathway potentially reverses hypoxia-induced drug resistance in TNBC.
Article
Engineering, Civil
Jianlong Zhang, Chunguo Zhang, Shengyong Mu, Shuai Wang, Hongchang Li
Summary: In this study, a method combining continuous indentation test and numerical simulation was established to accurately acquire the mechanical properties of nickel-based alloy 600 before and after creep. The high stress creep constitutive equation of alloy 600 in autoclave environment was obtained, and the influencing factors of mechanical properties were analyzed. The results showed that the mechanical properties of nickel-based alloy 600 increased with the increase of creep time, and the indentation test model verified by numerical simulation provided a nondestructive way to obtain the mechanical property parameters.
Article
Environmental Sciences
Zhaoxian Ni, Weiyan Liu, Gaofeng Pan, Anwei Mao, Jiazhe Liu, Qing Zhang, Jindong Li, Limin Liu, Hongchang Li
Summary: In this study, the regulatory relationship between circular forms of dedicator of cytokinesis 1 (circDOCK1) and miR-128-3p, as well as their implications in breast cancer pathogenesis mediated by never in mitosis related kinase 2 (NEK2), were explored. The results revealed an increase in circDOCK1 and NEK2 expression, and a decrease in miR-128-3p expression in breast cancer tissues and cell lines. CircDOCK1 was shown to promote breast cancer progression by targeting miR-128-3p-mediated downregulation of NEK2, suggesting that the circDOCK1/hsa-miR-128-3p/NEK2 axis may serve as a novel therapeutic target for breast cancer treatment.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Applied
Nguyen Ngoc Nghia, Bui The Huy, Dang Nguyen Nha Khanh, Nguyen Van Cuong, Hongchang Li, Yong -Ill Lee
Summary: Researchers have developed a new method for detecting tannic acid based on the fluorescent quenching effect and a smartphone-integrated reader system. The method uses a fluorescent polymer and Eu3+ ions to quench the fluorescence of tannic acid, and the smartphone captures and analyzes the fluorescence image. The method has been successfully applied to detect tannic acid in beverage samples.
Article
Geosciences, Multidisciplinary
Hongchang Li, Fang Gao
Summary: This paper improves the design of the separation and conveying machinery of the potato excavator in heavy soil by using the intelligent simulation method, and selects the grid-type excavation shovel. The designed equipment can ensure the least amount of soil entering into the subsequent separation device and reduce the load on it. By adopting the hydraulic transmission method, there is a flexible connection between the implement and the walking tractor, allowing relative movement between the two. The designed potato excavator separation and conveying equipment plays a certain role in potato harvesting in heavy soil.
PHYSICS AND CHEMISTRY OF THE EARTH
(2023)
Article
Green & Sustainable Science & Technology
Lihua Zuo, Hongchang Li, Xuanxuan Xia
Summary: Based on the background of the digital transformation of commercial banks, this study examines the promotion effect of digital finance on the production efficiency of commercial banks from four aspects: technological innovation, financial innovation, deep integration of technology and finance, and industry advantages. The study confirms that digital finance has a positive impact on the total factor productivity of commercial banks. The empirical research shows that digital finance strongly promotes the improvement of the total factor productivity of commercial banks through the technology spillover effect, indicating that the impact of digital finance on banks is heterogeneous.
Article
Green & Sustainable Science & Technology
Ying Chu, Shujun Ye, Hongchang Li, Jack Strauss, Chen Zhao
Summary: Financial inclusion is crucial for achieving the SDGs. Digitalization can be a powerful tool to promote inclusive financial services and sustainable development. This paper examines the effects of bank digitalization on sustainable financial inclusion and finds that it has positive effects on both financial inclusion and banks' sustainable development. The paper provides theoretical and empirical support for banks to build digitalization and improve financial inclusion, contributing to the triple-win financial ecology.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
