Article
Biophysics
Aabha Bajaj, Mohammad Abutoama, Sivan Isaacs, Marwan J. Abuleil, Karin Yaniv, Ariel Kushmaro, Martina Modic, Uros Cvelbar, Ibrahim Abdulhalim
Summary: Unwelcomed biofilms are a problem in environments where moisture is present, such as food industries and wastewater treatment plants. Advanced label-free sensors like surface plasmon resonance (SPR) have been explored for monitoring biofilm formation, but conventional noble metal SPR substrates have limited penetration depth, hindering reliable detection. In this study, a plasmonic insulator-metal-insulator (IMI) structure with higher penetration depth was proposed for portable SPR devices. The optimized IMI structure showed strong penetration dependence on wavelength and incidence angle, providing more reliable results compared to thin gold film substrates. The methodology can detect and characterize biofilms with better signal reliability.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Analytical
Suzuyo Inoue, Kenta Fukada, Katsuyoshi Hayashi, Michiko Seyama
Summary: This study developed a novel measuring and data-processing method for electrochemical surface plasmon resonance (EC-SPR), which can be used to detect sensor surfaces that are difficult to measure a specific SPR angle, especially for samples with non-uniform thickness and coloration like polymers. The proposed method combines SPR measurements with an electrochemical reaction to measure small molecules without increasing the number of measurement steps.
Article
Materials Science, Multidisciplinary
Yury Zhidik, Anna Ivanova, Serafim Smirnov, Klavdiya Zhuk, Igor Yunusov, Pavel Troyan
Summary: The development of plasmonics has led to the possibility of high-speed and highly sensitive optical sensors for analyzing chemical and biological media. In this study, the researchers demonstrate that the use of indium tin oxide (ITO) films with a high concentration of charge carriers can shift the surface plasmon resonance into the visible radiation region. The results show that SPR can be excited in ITO films with a concentration of free charge carriers, and the excitation wavelength of SPR can be changed by adding various analytes.
Article
Biochemistry & Molecular Biology
Jiaqi Guo, Xinyu Zhang, Jing Tian, Wenyuan Zhu, Junlong Song, Huining Xiao
Summary: In this study, the optical properties of ultrathin cellulose nanocrystal films deposited on gold surface of SPR sensors were determined using a two-medium SPR technique. The measured refractive index, porosity, and film thickness allowed for quality control of the modified SPR sensors before adsorption experiments. Overall, the results demonstrated the effectiveness of SPR surveys combined with Winspall analysis in determining the quality of ultrathin films on SPR sensors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Optics
Jingwen Feng, Jinjuan Gao, Wen Yang, Runcheng Liu, Muhammad Shafi, Zhipeng Zha, Cong Liu, Shicai Xu, Tingyin Ning, Shouzhen Jiang
Summary: This paper presents the fabrication of a D-shaped plastic optical fiber (D-POF) LSPR sensor based on a monolayer graphene/gold nanoparticles (Gr(m)/Au NPs) three-dimensional (3D) hybrid structure. The number of plasmonic structure layers was found to be important for sensor performance, with the optimal electromagnetic field enhancement effect observed in a three-layer plasmonic structure. The sensor exhibited outstanding sensitivity, linearity, and reproducibility, and successfully detected the concentration of glucose, suggesting promising applications in medicine and biotechnology.
Article
Polymer Science
Yi-Jung Lu, Han-Yun Hsieh, Wen-Chang Kuo, Pei-Kuen Wei, Horn-Jiunn Sheen, Hidetoshi Tahara, Te-Wei Chiu, Yu-Jui Fan
Summary: The study proposed a multiplex detection system by integrating LSPR sensing array and microfluidic channels, proving successful in detecting different targets in parallel channels.
Article
Multidisciplinary Sciences
Anouk Mentink, Khrystany T. Isebia, Jaco Kraan, Leon W. M. M. Terstappen, Michiel Stevens
Summary: When evaluating EpCAM-based enrichment technologies for CTCs, it is important to use cell lines that closely resemble real CTCs and measure the EpCAM expression of both CTCs and cell lines at different institutions and times. In this study, CTCs were enriched by depleting leukocytes from diagnostic leukapheresis products and EpCAM expression was measured using quantitative flow cytometry. Results showed varying but relatively low EpCAM expression in CTCs from castration-sensitive prostate cancer patients. There were also significant variations in antigen expression among identical cell lines cultured at different institutions, affecting capture efficiency.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Electrical & Electronic
Nancy Sidana, Prachi Rajput, Pooja Devi, Harminder Kaur
Summary: A highly sensitive and selective colorimetric sensor assay for detecting Hg2+ ions is presented in this study. This approach utilizes an anti-aggregation sensing method with AuNPs and an amine-based sensor (S) to achieve color variation from red to blue, indicating the presence of Hg2+ ions.
IEEE SENSORS JOURNAL
(2022)
Article
Biophysics
Richard B. M. Schasfoort, Jos van Weperen, Margot van Amsterdam, Judicael Parisot, Jan Hendriks, Michelle Koerselman, Marcel Karperien, Anouk Mentink, Martin Bennink, Hans Krabbe, Leon W. M. M. Terstappen, A. H. Leontine Mulder
Summary: The SPRi assay revealed that levels and binding strength of IgG antibodies against the RBD protein increased during the course of the disease in COVID-19 patients, while levels of IgM and IgA generally decreased. Recovered patients exhibited high binding strength of IgG antibodies to the RBD protein.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Biochemistry & Molecular Biology
Saadiya Zia, Komal Tehreem, Sidra Batool, Mehreen Ishfaq, Shaher Bano Mirza, Shahrukh Khan, Majed N. Almashjary, Mohannad S. Hazzazi, Husam Qanash, Ahmad Shaikh, Roua S. Baty, Ibrahim Jafri, Nouf H. Alsubhi, Ghadeer I. Alrefaei, Rokayya Sami, Ramla Shahid
Summary: This study found that the expression of EpCAM in cancer cells was inhibited by costunolide, suggesting that costunolide could be a potential therapeutic biomolecule for leukemia.
Article
Immunology
Zoltan Szittner, Arthur E. H. Bentlage, A. Robin Temming, David E. Schmidt, Remco Visser, Suzanne Lissenberg-Thunnissen, Juk Yee Mok, Wim J. E. van Esch, Myrthe E. Sonneveld, Erik L. de Graaf, Manfred Wuhrer, Leendert Porcelijn, Masja de Haas, C. Ellen van der Schoot, Gestur Vidarsson
Summary: The core fucosylation in anti-HPA-1a IgG greatly influences its binding to leukocyte IgG-Fc receptors IIIa/b. A cellular surface plasmon resonance imaging technique was developed to quantify the biological activity of IgG antibodies targeting cells.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Pengfei Zhang, Xinyu Zhou, Jiapei Jiang, Jayeeta Kolay, Rui Wang, Guangzhong Ma, Zijian Wan, Shaopeng Wang
Summary: Plasmonic scattering microscopy (PSM) adds a dry objective to a surface plasmon resonance (SPR) system, providing higher spatial resolution and larger field of view. PSM allows studying multiple cells simultaneously and quantifying the mechanical properties of cell-substrate contacts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Engineering, Electrical & Electronic
Roshni S. Babu, Hamish R. Colenso, Gideon J. Gouws, Baptiste Auguie, Ciaran P. Moore
Summary: This study investigated Ag-Au bimetallic surface plasmon resonance (SPR) sensors in the Kretschmann configuration. Ag-based sensors have high sensitivity but poor stability, while the addition of an Au capping layer improves chemical resistance and analyte bonding. Numerical modeling and experiments evaluated sensors with different Ag-Au thickness ratios, showing that the best SPR response was achieved with 45 nm Ag and 5 nm Au. The fabricated Ag-Au sensors were characterized, and the results were compared to single-layer Ag and Au sensors. The sensitivity of the thickness-optimized bimetallic layer was 1.5 times higher than that of the single-layer Au sensor.
IEEE SENSORS JOURNAL
(2023)
Article
Chemistry, Analytical
Shu-Cheng Lo, Shao-Sian Li, Wen-Fai Yang, Kuang-Chong Wu, Pei-Kuen Wei, Horn-Jiunn Sheen, Yu-Jui Fan
Summary: This paper presents a new micro/nanostructure co-hot embossing technique for the integration of gold-capped nanostructures as localized surface plasmon resonance (SPR) sensors into a microfluidic channel. The advantage of this technique is that it eliminates the need for alignment between the SPR sensors and the microfluidic channel during bonding. The integrated SPR sensor and microfluidic channel were characterized, and the sensitivity of the SPR sensor to refractive index was determined using different concentrations of glycerol solutions. The SPR sensor was also used for quantifying latent membrane protein (LMP-1) by modifying anti-LMP-1 on its surface, and a calibration curve was created using different concentrations of LMP-1 samples.
Article
Chemistry, Analytical
Chen-Ji Huang, Gudivada Vijaya Narasimha, Yu-Cheng Chen, Jen-Kun Chen, Guo-Chung Dong
Summary: The study focuses on evaluating the biological-physical interaction of micro-plastics with health cells and developing the movement mode and low concentration detection of micro-plastics using SPR technology. The research found that the movement mode of micro-plastics on estrogen receptors exhibited a rolling mode with certain characteristics and binding force.
Article
Cell Biology
Linda G. Rikkert, Frank A. W. Coumans, Chi M. Hau, Leon W. M. M. Terstappen, Rienk Nieuwland
Summary: A study developed a fast and simple single-step centrifugation protocol for producing high-quality platelet-free plasma for EV research. Compared to the traditional two-step protocol, the single-step protocol is faster, removes platelets effectively, and has a slightly higher plasma yield.
Article
Oncology
Pauline A. J. Mendelaar, Jaco Kraan, Mai Van, Leonie L. Zeune, Leon W. M. M. Terstappen, Esther Oomen-de Hoop, John W. M. Martens, Stefan Sleijfer
Summary: The study analyzed the size characteristics of CTCs in different cancer patients and found significant size differences among different tumor types, with CTCs being significantly smaller than cell line tumor cells. This has implications for designing and optimizing size-based isolation methods for CTCs.
MOLECULAR ONCOLOGY
(2021)
Article
Genetics & Heredity
Lars C. Steggink, Hink Boer, Coby Meijer, Joop D. Lefrandt, Leon W. M. M. Terstappen, Rudolf S. N. Fehrmann, Jourik A. Gietema
Summary: Genetic variation may play a role in the increased risk of cardiovascular disease in chemotherapy-treated testicular cancer patients. The study identified 141 independent genomic loci associated with CVD occurrence in this patient population, and DEPICT highlighted ten biological themes related to CVD.
PHARMACOGENOMICS JOURNAL
(2021)
Article
Biophysics
Richard B. M. Schasfoort, Jos van Weperen, Margot van Amsterdam, Judicael Parisot, Jan Hendriks, Michelle Koerselman, Marcel Karperien, Anouk Mentink, Martin Bennink, Hans Krabbe, Leon W. M. M. Terstappen, A. H. Leontine Mulder
Summary: The SPRi assay revealed that levels and binding strength of IgG antibodies against the RBD protein increased during the course of the disease in COVID-19 patients, while levels of IgM and IgA generally decreased. Recovered patients exhibited high binding strength of IgG antibodies to the RBD protein.
BIOSENSORS & BIOELECTRONICS
(2021)
Article
Medicine, General & Internal
Michiel Stevens, Peng Liu, Tom Niessink, Anouk Mentink, Leon Abelmann, Leon Terstappen
Summary: This study optimized the immunomagnetic enrichment process using a flow-through magnetophoretic system to increase sample size for more accurate treatment effects measurement and personalized therapy guidance. Experimental data confirmed the effectiveness of optimizing magnetophoretic separation methods in combination with cell lines of varying EpCAM antigen expression.
Correction
Biology
Pepijn Beekman, Agustin Enciso-Martinez, Sidharam P. Pujari, Leon W. M. M. Terstappen, Han Zuilhof, Severine Le Gac, Cees Otto
COMMUNICATIONS BIOLOGY
(2021)
Article
Biology
Pepijn Beekman, Agustin Enciso-Martinez, Sidharam P. Pujari, Leon W. M. M. Terstappen, Han Zuilhof, Severine Le Gac, Cees Otto
Summary: The study found that organosilicon compounds may interact with cell membranes passively and be adsorbed in or on the cell membrane; these compounds are commonly present in everyday items and widely used in food, cosmetics, and pharmaceuticals; with the increasing application of organosilicon compounds as replacements for other plastics, there is a need for a deeper understanding of these interactions.
COMMUNICATIONS BIOLOGY
(2021)
Correction
Biology
Pepijn Beekman, Agustin Enciso-Martinez, Sidharam P. Pujari, Leon W. M. M. Terstappen, Han Zuilhof, Severine Le Gac, Cees Otto
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
Menno Tamminga, Kiki C. Andree, Hilda van den Bos, T. Jeroen N. Hiltermann, Anouk Mentink, Diana C. J. Spierings, Peter Lansdorp, Wim Timens, Ed Schuuring, Leon W. M. M. Terstappen, Harry J. M. Groen
Summary: DLA detected nine times more CTCs than in the peripheral blood, and the sustained presence of CTCs in DLA after treatment was associated with therapy failure and shortened PFS.
BRITISH JOURNAL OF CANCER
(2022)
Article
Oncology
Michiel Stevens, Afroditi Nanou, Leon W. M. M. Terstappen, Christiane Driemel, Nikolas H. Stoecklein, Frank A. W. Coumans
Summary: This article explores the application of a deep learning-based segmentation method called StarDist in the enumeration of circulating tumor cells (CTC). Compared to the CellSearch system, StarDist can accurately segment CTC, especially in samples with high cell density.
Article
Oncology
Khrystany T. Isebia, Eshwari Dathathri, Noortje Verschoor, Afroditi Nanou, Anouk C. De Jong, Frank A. W. Coumans, Leon W. M. M. Terstappen, Jaco Kraan, John W. M. Martens, Ruchi Bansal, Martijn P. Lolkema
Summary: This study compared the composition of circulating tumor cells (CTCs) and tumor-derived extracellular vesicles (tdEVs) in the blood of patients with metastatic castration-naive prostate cancer (CNPC) and metastatic castration-resistant prostate cancer (CRPC). The study found potential differences between these biomarkers in the two disease stages, with lower CTC and tdEV levels in CNPC compared to CRPC patients. Furthermore, the study observed a decline in CTC/tdEV numbers 6 months after androgen deprivation therapy (ADT).
Article
Biochemical Research Methods
Richard B. M. Schasfoort
Summary: This paper presents a new SPR-imaging method that uses a ligand density gradient to extrapolate analyte response. This method avoids cumbersome optimization procedures and minimizes surface dependent effects. The method can be fully automated for accurate determination of antibody quality from commercial sources.
ANALYTICAL BIOCHEMISTRY
(2023)
Article
Oncology
Tao Lu, Lisa Oomens, Leon W. M. M. Terstappen, Jai Prakash
Summary: Cancer-associated fibroblasts (CAFs) are important drivers in the tumor microenvironment and facilitate the growth and survival of tumor cells, as well as metastasis formation. In this study, we aimed to study circulating CAFs (cCAFs) and circulating tumor cells (CTCs) in a preclinical breast tumor model in mice in order to understand the effect of chemotherapy on cCAFs and CTC formation. We found that tumors with CAFs grew faster than tumors without CAFs. Furthermore, chemotherapy may exacerbate the formation of cCAFs and CTCs, which may eventually support the formation of a metastasis niche in breast cancer.
Article
Multidisciplinary Sciences
Richard B. M. Schasfoort, Jos van Weperen, Margot van Amsterdam, Judicael Parisot, Jan Hendriks, Michelle Koerselman, Marcel Karperien, Anouk Mentink, Martin Bennink, Hans Krabbe, Leon W. M. M. Terstappen, A. H. Leontine Mulder
Summary: The study used Surface Plasmon Resonance imaging to analyze the presence and strength of binding of IgG, IgM, and IgA against the Receptor Binding Domain of SARS-CoV-2 in 102 CoViD-19 and non-CoViD-19 patients' sera. The results showed that IgG levels and strength of binding increased during the course of the disease, while IgM and IgA levels generally decreased. Recovered patients exhibited high strength of binding of IgG to the RBD protein. The SPRi assay provides additional insights into the immune status of patients recovering from CoViD-19.
Meeting Abstract
Oncology
Christina Guo, Mateus Crespo, Bora Gurel, David Dolling, Jan Rekowski, Adam Sharp, Antonella Petremolo, Semini Sumanasuriya, Daniel N. Rodrigues, Ana Ferreira, Rita Pereira, Ines Figueiredo, Niven Mehra, Maryou B. K. Lambros, Antje Neeb, Veronica Gil, Leon Terstappen, Andrea Alimonti, Charles G. Drake, Wei Yuan, Johann S. de Bono
CANCER IMMUNOLOGY RESEARCH
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
