Article
Entomology
Basman H. Al-Jalely, Wei Xu
Summary: The study focused on the olfactory system of Trichogramma pretiosum, identifying 22 putative odorant binding proteins (OBPs) and 105 odorant receptors (ORs) using scanning electron microscopy to observe four types of olfactory sensilla. By examining the expression patterns of OBPs in male and female adults, three female-specific OBPs were identified, suggesting their crucial roles in host-seeking and oviposition behaviors. This research enriches our understanding of T. pretiosum olfactory genes and enhances our knowledge of its olfactory system.
Article
Cell Biology
L. Gonzalez-Brusi, J. G. Hamze, I Lamas-Toranzo, M. Jimenez-Movilla, P. Bermejo-Alvarez
Summary: This study aimed to identify sperm proteins interacting with the TMEM95 protein, which is essential for fertilization. Mass spectrometry identified 41 sperm proteins pulled down with TMEM95, suggesting an independent role of TMEM95 in fertilization. Among these proteins, OLFR601 is located in the acrosomal region and may mediate affinity for an odorant involved in fertilization. However, disruption of OLFR601 did not impair sperm fertilization ability, suggesting redundant function with other sperm proteins.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Patrick Marcinek, Franziska Haag, Christiane Geithe, Dietmar Krautwurst
Summary: Molecular recognition plays a key role in biological systems, and the study of pyrazines has led to the discovery of OR5K1 as a specialized olfactory receptor across mammals for the detection of pyrazine-based key food odors and semiochemicals, indicating the significance of ecological evolution.
Article
Biology
Sho Kurihara, Masayoshi Tei, Junichi Hata, Eri Mori, Masato Fujioka, Yoshinori Matsuwaki, Nobuyoshi Otori, Hiromi Kojima, Hirotaka James Okano
Summary: Combined high-field MRI and DTI analyses allow visualization of olfactory sensory neurons and their projections, providing olfactory nerve maps in humans, marmosets, and mice. This technique has the potential to be used clinically for the diagnosis of olfactory dysfunction.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Applied
Weihong Liu, Yu Zheng, Chen Zhang, Lin Chen, Hanyi Zhuang, Guojun Yao, Hang Ren, Yingjian Liu
Summary: In this study, a biomimetic olfactory recognition system was developed to discriminate the aromas of Chinese liquors. By combining odorant receptors and machine learning, the system demonstrated high accuracy in differentiating liquors of different aroma types, brands, and ageing years. The interactions between liquor aroma compounds and odorant receptors were also elucidated, providing insights into odorant coding at the molecular level.
Article
Biochemistry & Molecular Biology
Ryosuke Inoue, Yosuke Fukutani, Tatsuya Niwa, Hiroaki Matsunami, Masafumi Yohda
Summary: Olfactory receptors (ORs) in olfactory sensory neurons mediate olfaction and require the assistance of receptor-transporting proteins (RTPs) for functional expression. This study examined the interactome of RTP1S and OR using proximity biotinylation and revealed the involvement of HSPA6 and STAU2 in the trafficking process of OR through interaction with RTP1S.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Kevin W. Zhu, Shawn D. Burton, Maira H. Nagai, Justin D. Silverman, Claire A. de March, Matt Wachowiak, Hiroaki Matsunami
Summary: This study utilized targeted spatial transcriptomics to map the distribution of olfactory receptors in the murine olfactory bulb and generated a 3D model. The findings revealed a relationship between receptors and odorants, providing significant insights into olfaction.
NATURE COMMUNICATIONS
(2022)
Article
Agronomy
Xueqin Pan, Jun Liu, Xiao Xu, Liwei Zhang, Long Zhang
Summary: Choosing palatable plants is crucial for insect herbivores' survival, especially for restricted-feeders that specialize on few types of plants. However, the definitive strategy and sensory basis for distinguishing between host and nonhost plants remains controversial. In this study, we investigated the olfactory recognition of host plants in migratory locusts that feed on a limited range of plants. By using a novel behavioral paradigm, we found that the palps of locusts are necessary for differentiating between host and nonhost plants. The characteristic odors of the plants determined the behavioral differentiation, and intact palps were required for this process. We also identified the odorant receptors in the palps that modulate the recognition of key volatiles from host and nonhost plants, demonstrating the role of olfactory signaling in food choice.
Article
Biochemistry & Molecular Biology
R. Jason Pitts, Robert M. Huff, Shan Ju Shih, Jonathan D. Bohbot
Summary: The research identifies indolOR genes in mosquitoes, flies, and Culicidae, shedding light on insect chemical ecology and providing targets for novel odor-based tools.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jane S. Huang, Tenzin Kunkhyen, Alexander N. Rangel, Taryn R. Brechbill, Jordan D. Gregory, Emily D. Winson-Bushby, Beichen Liu, Jonathan T. Avon, Ryan J. Muggleton, Claire E. J. Cheetham
Summary: The study reveals that immature olfactory sensory neurons (OSNs) play a crucial role in the olfactory bulb (OB) circuit of mice by providing odor input and forming monosynaptic connections with excitatory neurons. Immature OSNs show stronger selective responses to odorants and graded responses across a wider range of odorant concentrations compared to mature OSNs. Furthermore, mice can successfully perform odor detection and discrimination tasks using sensory input from immature OSNs alone.
NATURE COMMUNICATIONS
(2022)
Article
Entomology
Yu Zhang, Kai Feng, Ruolan Mei, Wei Li, Fang Tang
Summary: This study used transcriptome sequencing to investigate the expression of antennal genes in Micromelalopha troglodyta and identified olfactory-related genes. The results showed that these genes are abundantly expressed in the antennae and head, laying the foundation for future research on the olfactory system in M. troglodyta and providing a theoretical basis for biological control.
JOURNAL OF INSECT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Dania Jundi, Jean-Pierre Coutanceau, Erika Bullier, Soumaiya Imarraine, Ziad Fajloun, Elim Hong
Summary: The expression of olfactory receptor (OR) genes in non-olfactory tissues has been found in rodents and humans, with over 400 genes in humans and 1000 in rodents. Zebrafish have around 140 OR genes, with 31 genes expressed in various tissues, showing conservation of expression in non-olfactory tissues across vertebrates.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Cecile Heraud, Theo Hirschinger, Elodie Baranek, Laurence Larroquet, Anne Surget, Franck Sandres, Anthony Lanuque, Frederic Terrier, Jerome Roy
Summary: This study aimed to elucidate the role of the sensory olfactory pathways in the regulation of feeding behavior in carnivorous rainbow trout. The researchers found that a total plant-based diet had a significant impact on the growth performance and feed intake of the trout. Gene expression analysis showed that OLFC and MOR genes played important roles in olfactory sensing perception. Additionally, the plant-based diet affected olfactory sensing pathways and monoaminergic neurotransmission in brain areas related to olfactory-driven behaviors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Dania Jundi, Jean-Pierre Coutanceau, Erika Bullier, Soumaiya Imarraine, Ziad Fajloun, Elim Hong
Summary: This study identified the expression of 31 out of 36 olfactory receptor (OR) genes in various tissues in zebrafish larvae, including trunk, pharynx, pancreas, and brain; furthermore, some OR genes exhibited dynamic temporal expression patterns in specific brain regions across different developmental stages of zebrafish, such as the hypothalamus and the habenula.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Luis Flores Horgue, Alexis Assens, Leon Fodoulian, Leonardo Marconi, Joel Tuberosa, Alexander Haider, Madlaina Boillat, Alan Carleton, Ivan Rodriguez
Summary: This study reveals that the diversity of olfactory neurons in mice is influenced by both the chemoreceptor expressed by each neuron and the experience of that neuron. The transcriptomic profiles of mouse olfactory sensory neurons are already divergent at rest, specific to the olfactory receptor they express, and can further evolve in response to environmental stimuli. These findings contribute to our understanding of the complexity and adaptability of sensory coding.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Ying-Gui Yang, Young Wha Koh, Ita Novita Sari, Nayoung Jun, Sanghyun Lee, Lan Thi Hanh Phi, Kwang Seock Kim, Yoseph Toni Wijaya, Sang Hun Lee, Moo-Jun Baek, Dongjun Jeong, Hyog Young Kwon
INTERNATIONAL JOURNAL OF CANCER
(2019)
Article
Biochemistry & Molecular Biology
Eun Ji Kang, Yu Mi Baek, Eunil Hahm, Sang Hun Lee, Xuan-Hung Pham, Mi Suk Noh, Dong-Eun Kim, Bong-Hyun Jun
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Endocrinology & Metabolism
Yong-Seok Han, Sang Min Kim, Jun Hee Lee, Seo Kyung Jung, Hyunjin Noh, Sang Hun Lee
JOURNAL OF PINEAL RESEARCH
(2019)
Article
Telecommunications
Hyun-Ho Han, Seuc-Ho Ryu, Gyoo-Soo Chae, Sang-Hun Lee
WIRELESS PERSONAL COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Jun Hee Lee, Yeo Min Yoon, Sang Hun Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Chul Won Yun, Sang Hun Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Chemistry, Physical
Xuan-Hung Pham, Eunil Hahm, Eunji Kang, Yu Na Ha, Sang Hun Lee, Won-Yeop Rho, Yoon-Sik Lee, Dae Hong Jeong, Bong-Hyun Jun
JOURNAL OF ALLOYS AND COMPOUNDS
(2019)
Article
Oncology
Hyun Jin Roh, Eun Byeol Go, Kyung Bin Kim, Jong Hwa Lee, Sang Hun Lee
ANTICANCER RESEARCH
(2019)
Review
Medicine, General & Internal
Jong Hwa Lee, Hyun Jin Roh, Jun Woo Ahn, Jeong Sook Kim, Jin Young Choi, Soo-Jeong Lee, Sang Hun Lee
JOURNAL OF CLINICAL MEDICINE
(2020)
Review
Medicine, General & Internal
Jin-Young Choi, Song-Soo Yang, Jong-Hwa Lee, Hyun-Jin Roh, Jun-Woo Ahn, Jeong-Sook Kim, Soo-Jeong Lee, Sang-Hun Lee
Summary: Congenital diaphragmatic hernia, especially Bochdalek hernia, during pregnancy is rare but can lead to high morbidity and mortality. Early diagnosis and surgical intervention are crucial, with multidisciplinary care and individualized treatment being key to optimal results for both the mother and fetus.
Review
Medicine, General & Internal
Ok Ju Kang, Ji Hye Koh, Ji Eun Yoo, So Yeon Park, Jeong-Ik Park, Songsoo Yang, Sang-Hun Lee, Soo-Jeong Lee, Jun-Woo Ahn, Hyun-Jin Roh, Jeong Sook Kim
Summary: Non-tubal ectopic pregnancies with abdominal hemorrhaging have significantly higher mortality and morbidity rates compared to tubal pregnancies. Prompt diagnosis and management through laparoscopic surgery are crucial for improving prognosis in cases of primary diaphragmatic ectopic pregnancy with hemorrhage.
Review
Medicine, General & Internal
Hyoeun Kim, Ji Hye Koh, Jihee Lee, Yeongeun Sim, Sang-Hun Lee, Soo-Jeong Lee, Jun-Woo Ahn, Hyun-Jin Roh, Jeong Sook Kim
Summary: This case report presents a successful treatment for heterotopic cesarean scar pregnancy, using selective potassium chloride injection into the scar pregnancy and uterine cerclage to control vaginal bleeding, resulting in the preservation of the intrauterine pregnancy and full-term delivery.
Review
Medicine, General & Internal
Sang Hun Lee, Songsoo Yang, Inkyu Park, Yeong Cheol Im, Gyu Yeol Kim
Summary: This case report describes a 33-year-old pregnant woman who experienced a sudden onset of epigastric pain at 18 weeks of pregnancy due to a ruptured SAA. After emergent intervention and surgery, the woman recovered without complications and was discharged 15 days postoperatively, even though the fetus was found to be dead during resuscitation.
WORLD JOURNAL OF CLINICAL CASES
(2022)
Article
Urology & Nephrology
Seong Cheol Kim, Won Hyeok Lee, Song Hee Kim, Abdumadjidov Alisher Abdulkhayevich, Jeong Woo Park, Young Min Kim, Kyung Hyun Moon, Sang Hun Lee, Sungchan Park
Summary: This study confirms the association between DRG2 expression and docetaxel-induced apoptosis in prostate cancer cells. Knockdown of DRG2 increases docetaxel-induced apoptosis without G2/M arrest, showing potential to enhance treatment outcomes in castration-resistant prostate cancer.
INVESTIGATIVE AND CLINICAL UROLOGY
(2021)
Article
Oncology
Jeong-Yeol Park, Sang-Hun Lee, Kyu-Rae Kim, Young-Tak Kim, Joo-Hyun Nam
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2019)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)