Article
Chemistry, Applied
Qiaoting Yang, Suixin Zhao, Haiyin Li, Feng Li
Summary: In this study, a cathodic ECL sensor was developed for highly sensitive and reliable analysis of organophosphorus pesticides (OPs). The sensor, utilizing CdTe quantum dots as emitters, showed simultaneous response to thiol and acidic pH, and successfully detected methidathion.
Article
Chemistry, Analytical
Yunfeng Fan, Zhimin Liu, Jie Wang, Chen Cui, Leqian Hu
Summary: A novel electrochemiluminescence aptasensor for the determination of lincomycin has been developed, showing a wide detection range and low detection limit, as well as outstanding accuracy and specificity. It also provides a potential strategy for other antibiotic determinations.
Article
Chemistry, Analytical
Beatriz Diez-Buitrago, Laura Saa, Nerea Briz, Valeri Pavlov
Summary: In this study, a portable and disposable screen-printed electrode-based platform for CdS QDs electrochemiluminescence (ECL) detection was developed. The electrode modification process was optimized and enzymatic assays were used to modulate the CdS QDs ECL signal. This methodology shows potential applications for the development of sensitive biosensors and was successfully applied to the determination of AChE and methanol in real samples.
Article
Engineering, Environmental
Peilin Wang, Yixin Nie, Yu Tian, Zihui Liang, Shuping Xu, Qiang Ma
Summary: In this study, a surface enhanced electrochemiluminescence (SEECL) sensing system based on whispering gallery mode was developed, utilizing Ni-doped MoS2 quantum dots as ECL emitters. This system incorporated Au nanoparticles and SiO2 dielectric microspheres to enhance ECL intensity, allowing for quantification of the K-RAS gene with a detection limit of 0.3 fM.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Analytical
Defen Feng, Fucun Wei, Yeyu Wu, Xuecai Tan, Fang Li, Yongkuai Lu, Gaochao Fan, Heyou Han
Summary: An ultrasensitive ECL biosensor was developed using MIL-53(Al)@CdS QDs and SiO2@AuNPs for trichlorfon detection, showing a linear relationship with a detection limit of 5.1 x 10(-12) M. The biosensor demonstrated potential applications in analyzing trichlorfon in food samples with high recoveries.
Article
Chemistry, Analytical
Weiwei Luo, Hongyu Chu, Xinzhao Wu, Pinyi Ma, Qiong Wu, Daqian Song
Summary: A highly sensitive disposable self-enhanced off-on electrochemiluminescence (ECL) biosensor was developed to detect the biomarker caspase-3 activity, which is related to cancer cell apoptosis. This biosensor has a low detection limit, enhanced ECL emission and stability, and utilizes a solid-state ECL strategy to overcome weak emission issues. Introducing disposable screen-printed electrodes enables on-site rapid detection capabilities, laying the foundation for the development of advanced portable ECL devices for biosensing various bioanalytes.
Article
Urology & Nephrology
Shuangjun He, Meng Zhou, Hongming Zheng, Yaowei Wang, Shuhua Wu, Yuan Gao, Jianhong Chen
Summary: This study explored the effect of resveratrol on premature senescence and revealed potential mechanisms through network pharmacology. The results demonstrated that resveratrol alleviated premature senescence by targeting the RELA/SIRT1 axis. This finding provides a potential target for the treatment of premature senescence.
Article
Biochemistry & Molecular Biology
Aya Twair, Issam Kassem, Hossam Murad, Abdul Qader Abbady
Summary: The study successfully demonstrated the expression of fusion ANXV protein in mammalian cells as an alternative to E. coli expression system, with the protein yield sufficient for recognizing and binding PS-containing surfaces. The secreted sfGFP-ANXV in eukaryotic system shows promise as a biotechnological tool for detecting PS bearing surfaces and apoptosis in both in vitro and in vivo assays.
JOURNAL OF MEMBRANE BIOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Kai Han, Jianjun Luo, Jian Chen, Baodong Chen, Liang Xu, Yawei Feng, Wei Tang, Zhong Lin Wang
Summary: A self-powered ammonia synthesis system using the Tesla turbine TENG was designed, showing a yield of 2.14 μg/h (0.126 μmol/h) under ambient conditions. The high-energy plasma generated by the system can react with water molecules to directly produce ammonia, indicating great potential for large-scale synthesis.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Engineering, Biomedical
Xueqin Huang, Huaihong Cai, Haibo Zhou, Ting Li, Hua Jin, Colin E. Evans, Jiye Cai, Jiang Pi
Summary: Manipulating protein degradation pathways such as ALP and UPS with Co3O4 NPs can enhance anticancer treatments by inducing autolysosome accumulation and inhibiting lysosomal proteolytic activity. Combining Co3O4 NPs with proteasome inhibitors also promotes the accumulation of autophagic substrates and protein ubiquitination to inhibit cancer progression. Additionally, leveraging the photothermal conversion efficiency of Co3O4 NPs enhances the anticancer efficacy of existing treatments in vitro and in vivo.
ACTA BIOMATERIALIA
(2021)
Article
Pharmacology & Pharmacy
Ke Changhong, Yuan Peng, Zhengqiang Yuan, Jiye Cai
Summary: The study found that ginsenoside Rb1 can protect cells from Aβ-induced cytotoxicity, acting as an agonist of PPARγ to reduce cholesterol levels in AD model cells. Lowering cholesterol levels reduced Aβ-induced cytotoxicity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Jianjun Luo, Wenchao Gao, Zhong Lin Wang
Summary: In the new era of the Internet-of-Things, the development of intelligent sports relies heavily on athletic big data collection and analysis using widely distributed sensing networks. The triboelectric nanogenerator (TENG) has shown great potential in overcoming limitations of conventional sensors with its mechanical energy harvesting and self-powered sensing technology, fabricated using common materials like wood and paper. Progress on TENG-based sports sensing systems, including smart sports facilities and wearable equipment, as well as the remaining challenges and open opportunities in the field of intelligent sports, are summarized.
ADVANCED MATERIALS
(2021)
Article
Chemistry, Analytical
Shuangyang Kuang, Xiaochen Suo, Peiyi Song, Jianjun Luo
Summary: This research presents the design and construction of an instantaneous self-powered sensing system using a planar-structured rotary triboelectric nanogenerator and an instantaneous driving mode power management circuit, demonstrating its potential in various applications such as smart home, environment monitoring, and security surveillance.
Article
Chemistry, Multidisciplinary
Xue Shi, Jianjun Luo, Jianzhe Luo, Xunjia Li, Kai Han, Ding Li, Xia Cao, Zhong Lin Wang
Summary: This study reports a self-powered sensor based on natural wood for building smart home systems. The sensor exhibits superior sensitivity, flexibility, stability, and thinness, and can be integrated with household facilities for various applications in smart home control, gate control, and floor monitoring.
Article
Chemistry, Physical
Jianjun Luo, Kai Han, Xueqiang Wu, Huaihong Cai, Tao Jiang, Haibo Zhou, Zhong Lin Wang
Summary: This study reported a high-performance and durable triboelectric nanogenerator (TENG) for self-powered medical health improvement. By enhancing the electrical output performance through a double tribo-layers strategy, and introducing an automatic working mode transition design, the TENG's durability is greatly improved. The high output voltage of TENG is utilized to develop self-powered mosquito-killing and ultraviolet sterilization systems, expanding the application area of self-powered systems to infectious disease prevention.
Article
Nanoscience & Nanotechnology
Haiying Kou, Haiming Wang, Renwei Cheng, Yanjun Liao, Xue Shi, Jianjun Luo, Ding Li, Zhong Lin Wang
Summary: A pressure-sensitive smart pillow is developed using a flexible and breathable triboelectric nanogenerator (TB-TENG) sensor array to monitor head movement during sleep. The smart pillow also has an early warning function for falling out of bed.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Jianing Dong, Siying Huang, Jianjun Luo, Jiawei Zhao, Feng Ru Fan, Zhong-Qun Tian
Summary: This paper presents a newly designed TENG based on electrostatic double layer formed by electrostatic charges adsorbing on the surface of the dielectric layer. After charging, the output power was enhanced by thirteen times. Additionally, a compressible self-charging power system composed of TENG and SC was fabricated to sustainably drive electric devices.
Article
Chemistry, Physical
Kai Han, Jianjun Luo, Jian Chen, Yujin Liu, Jinliang Li, Zhong Lin Wang, Wenjie Mai
Summary: Electroaerodynamics (EAD) force, a propulsion method without combustion emissions, has great potential. By combining lightweight EAD thrusters and high-voltage output triboelectric nanogenerators (TENG), successful propulsion systems can be achieved.
Article
Materials Science, Multidisciplinary
Jianjun Luo, Xue Shi, Pengfei Chen, Kai Han, Xunjia Li, Xia Cao, Zhong Lin Wang
Summary: In this study, a strong and flame-retardant wood-based self-powered building fire protection device was developed. By improving the mechanical strength and flame retardancy of the wood, the performance of the device was greatly enhanced. The device not only increased the strength of the flame-retardant wood and reduced the peak heat release rate, but also had the property of self-extinguishing. The device was further used to develop a self-powered intelligent wireless fire monitoring and escape route guidance system.
MATERIALS TODAY PHYSICS
(2022)
Review
Chemistry, Multidisciplinary
Xue Shi, Kai Han, Yaokun Pang, Wenjie Mai, Jianjun Luo
Summary: Security monitoring is crucial for ensuring the safety and stability of people's daily lives, and the development of intelligent sensing technology is driving the advancement of electronic devices and new application requirements. This review summarizes the recent progress in triboelectric nanogenerators (TENGs) as self-powered intelligent sensors for monitoring various biometric characteristics, including sliding behavior, handwriting behavior, keystroke dynamics, gait characteristics, and voice characteristics. The applications of self-powered systems based on TENGs in individual electronics authentication and home security are also comprehensively summarized, along with the remaining challenges and open opportunities.
Article
Chemistry, Physical
Xue Shi, Pengfei Chen, Kai Han, Chengyu Li, Renyun Zhang, Jianjun Luo, Zhong Lin Wang
Summary: The demand for fast, reliable, and accessible information in the connected world has made disposable sensors increasingly important. A low-cost, biodegradable, and recyclable all-lignocellulosic triboelectric nanogenerator (AL-TENG) has been developed for self-powered disposable medical monitoring. This work expands the application of self-powered systems to disposable medical sensing and promotes the development of intelligent wards and disposable electronics.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Food Science & Technology
Xunjia Li, Jianjun Luo, Kai Han, Xue Shi, Zewei Ren, Yi Xi, Yibin Ying, Jianfeng Ping, Zhong Lin Wang
Summary: This article introduces a wind and rain energy-driven electrical stimulation system for enhancing crop production. The system utilizes a triboelectric nanogenerator and a raindrop-driven nanogenerator, which can significantly increase the germination speed and yield of pea seeds through the self-generated high-voltage electric field. By harnessing environmental energy, the system can drive agricultural sensors to optimize plant growth.
Article
Chemistry, Multidisciplinary
Kai Han, Jianjun Luo, Yawei Feng, Liang Xu, Wei Tang, Zhong Lin Wang
ENERGY & ENVIRONMENTAL SCIENCE
(2020)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
