Article
Chemistry, Analytical
Shuge Liu, Ping Zhu, Yulan Tian, Yating Chen, Yage Liu, Miaomiao Wang, Wei Chen, Liping Du, Chunsheng Wu
Summary: A taste bud organoid-based biosensor was developed for the study of taste sensations. Results showed that the biosensor could efficiently monitor the electrophysiological signals from taste bud organoids in response to various taste stimuli.
Article
Engineering, Environmental
Mustafa Yavuz Celik, M. Resit Korucu
Summary: Three types of carbonate building stones from Turkey were tested for their physical and mechanical properties after freeze-thaw cycles with salt solutions. Material characterization, including chemical and mineralogical-petrographic tests, pore size distribution, and physico-mechanical tests, was performed. The results showed that water absorption, uniaxial compressive strength, and ultrasonic wave measurement values of all samples increased after multiple freeze-thaw cycles. However, the water absorption of silver travertine and Burdur limestone decreased due to the presence of small pores. The ultrasonic pulse velocity (UPV) values of travertine samples decreased gradually with more freeze-thaw cycles, and the uniaxial compressive strength (UCS) values of all samples decreased in all solutions.
BULLETIN OF ENGINEERING GEOLOGY AND THE ENVIRONMENT
(2023)
Article
Chemistry, Physical
Qing-Jie Li, David Sprouster, Guiqiu Zheng, Jorg C. Neuefeind, Alexander D. Braatz, Joanna Mcfarlane, Daniel Olds, Stephen Lam, Ju Li, Boris Khaykovich
Summary: The resurgence of molten salt nuclear reactors creates interesting problems in molten salt chemistry, where the composition and properties of salts change due to fission and corrosion. A study on atomic structure of molten NaCl-CrCl3 found networks of CrCl63- octahedra and an intermediate-range order with a non-monotonic temperature behavior, in agreement with ab initio simulations. The corrosion results in minute quantities of dissolved Cr, leading to potential changes in molten-salt properties.
ACS APPLIED ENERGY MATERIALS
(2021)
Article
Nutrition & Dietetics
Isabella Hartley, Nanna Riis, Djin Gie Liem, Russell Keast
Summary: This study found that oral exposure is more important than consumption in modulating taste perception. After a two-week intervention of oral exposure, taste function improved, with reduced perception of saltiness and enhanced ability to discriminate umami. This suggests that regulating salt taste function may require a coordinated response between oral activation and sodium consumption.
JOURNAL OF NUTRITION
(2023)
Article
Chemistry, Physical
Yuzhu Lu, Chuangang Ning
Summary: This study reports the energy-difference measurement of a salt-water complex and discovers three isomers for both the negatively charged and neutral complexes. These results can serve as a benchmark for the development of theoretic methods for weakly bound complexes.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Biophysics
Yuxia Fan, Yulin Huang, Ninglong Zhang, Gaole Chen, Shui Jiang, Yin Zhang, Guangchang Pang, Wenli Wang, Yuan Liu
Summary: This study investigated the distribution and signal coding logic of umami receptors on the tongue using taste bud biosensors. The results showed different response currents of taste bud biosensors to MSG and IMP, with T1R1 receptor being more expressed in the rostral tongue cells with higher sensitivity to MSG. This method has the potential to explain the interaction mechanism of umami substances with their receptors more accurately and develop artificial intelligent taste sensory.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Multidisciplinary Sciences
G. Licsandru, C. Noiriel, S. Geoffroy, A. Abou-Chakra, P. Duru, M. Prat
Summary: Research has found that salt crusts formed on the surface of porous materials can affect the evaporation process and pose a risk to the stability of these materials. Dissolution-precipitation processes have been identified as key mechanisms in the detachment of salt crusts, which have a low permeability. The study also demonstrates that salt structures in a water vapor concentration gradient can propel themselves and carry small objects.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Physical
Leann Tran, Jiri Skvara, William R. Smith
Summary: Knowledge of the vapor-liquid equilibrium properties of molten salts is important but challenging to determine experimentally. This study presents a thermodynamic-based atomistic simulation framework for predicting these properties and applies it to NaCl. The framework can predict vapor pressure, phase densities, composition, and vaporization enthalpy, and can even estimate concentrations of minor vapor phase species. It is verified using experimental data and can be extended to molten salt mixtures and ionic liquids.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Qi Zhang, Jun Li
Summary: This study reveals the microsolvation process of NaCl(H2O) and NaCl(H2O)(-) salts in water through comprehensive calculations and analysis. The structural rearrangements of the neutral NaCl(H2O) and NaCl(H2O)(-) anions are mainly caused by breaking and forming of hydrogen bonds and the enhancement and weakening of interactions between Na and O atoms. The distributions of anion complexes and the photoelectron spectra of the anions are computed and analyzed, showing good agreement with experimental results.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Neurosciences
Rebecca A. A. Frederick, Ellen Shih, Vernon L. L. Towle, Alexandra Joshi-Imre, Philip R. R. Troyk, Stuart F. F. Cogan
Summary: This study evaluated the stability of implantable devices and stimulation electrodes in saline and canine visual cortex. The results showed that the AIROF electrodes remained stable during pulsing and maintained consistent performance in vivo.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Biophysics
Liqin Kong, Yijian Wang, Guoqiang Shu, Renfa Wang, Yaoze Feng, Ming Zhu
Summary: A new biosensor was developed to detect umami substances, their synergistic effect, and detection kinetics. The taste-bud tissue sensors showed different responses to MSG stimuli, with those based on a tip and mediolateral tongue being the most sensitive. The study also revealed the synergistic effect of umami substances and the sensitivity of sensors to umami variations.
BIOSENSORS & BIOELECTRONICS
(2022)
Editorial Material
Urology & Nephrology
Matthew A. Bailey
Summary: Salbutamol activates NaCl cotransporter in the distal convoluted tubule and combined with high salt intake can induce hypertension in mice, which can be rescued by thiazide therapy. Phosphoproteomics identified protein phosphatase 1/inhibitor 1 as a distinct regulatory node for NaCl cotransporter activation by salbutamol. Salbutamol, commonly used in respiratory medicine, may contribute to salt sensitivity and cardiovascular risk in certain patients.
KIDNEY INTERNATIONAL
(2021)
Article
Peripheral Vascular Disease
Xuejun Yin, Ellie Paige, Maoyi Tian, Qiang Li, Liping Huang, Jie Yu, Anthony Rodgers, Paul Elliott, Yangfeng Wu, Bruce Neal
Summary: The SSaSS study found that potassium-enriched salt can have definitive effects on cardiovascular outcomes and death. By quantifying the amount of potassium-enriched salt used, researchers were able to estimate the impact on risk reduction and the potential for population-wide scale-up. The results showed that even a partial replacement of regular salt with potassium-enriched salt can deliver significant health gains.
Review
Food Science & Technology
Julian Andres Gomez-Salazar, Andrea Galvan-Navarro, Jose M. Lorenzo, Maria Elena Sosa-Morales
Summary: Health concerns drive salt reduction in diverse foods, including processed meats; ultrasound technology shows promise in reducing salt content in meat products by shortening curing time; optimization of ultrasound parameters is necessary due to variation in structure and composition among different meat products.
CURRENT OPINION IN FOOD SCIENCE
(2021)
Article
Physics, Multidisciplinary
Chunyi Zhang, Shuwen Yue, Athanassios Z. Panagiotopoulos, Michael L. Klein, Xifan Wu
Summary: The dielectric permittivity of salt water decreases as more salt is dissolved, which is explained by saturation in the dielectric response of solvent water molecules. By using an advanced deep neural network (DNN) based on density functional theory data, the dielectric permittivity of sodium chloride solutions is studied. The computed decrease in dielectric permittivity as a function of concentration, using the DNN approach, agrees well with experimental results. The dominant effect causing this decrease is the intrusion of ionic hydration shells into the solvent hydrogen-bond network, disrupting dipolar correlations among water molecules and suppressing the collective response of solvent waters.
PHYSICAL REVIEW LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Changhong Linghu, Xudong Yang, Yangchengyi Liu, Dong Li, Huajian Gao, Jimmy Hsia
Summary: This study investigates the mechanics of adhesion between shape memory polymers (SMPs) and a rigid spherical indenter through experimental testing, theoretical analysis, and finite element analysis. The results reveal that the orders of magnitude enhancement of adhesion in SMPs compared to conventional elastic adhesion systems is mainly due to the shape locking effect during the transition from the rubbery to glassy states, which increases the effective radius of curvature of the contact surface.
JOURNAL OF THE MECHANICS AND PHYSICS OF SOLIDS
(2023)
Article
Chemistry, Multidisciplinary
Jiaru Fang, Dongxin Xu, Hao Wang, Jin Wu, Ying Li, Tao Yang, Chuan Liu, Ning Hu
Summary: Electrophysiology is a unique biomarker for disease investigation or drug assessment in electrogenic cells. Vertical nanoelectrode arrays have been successful in achieving high-quality intracellular electrophysiological study in electrogenic cells. However, achieving high success rate and high-quality, long-term intracellular recording using inexpensive nanostructures remains a challenge. In this study, a scalable and robust hollow nanopillar electrode was developed to enhance intracellular recording of cardiomyocytes. Regulation of the nanostructure geometry proved to be a powerful strategy in enhancing intracellular recording.
Article
Chemistry, Analytical
Hao Wang, Quchao Zou, Yuting Xiang, Jinhu Yang, Zhongyuan Xu, Wenjian Yang, Yue Wu, Jin Wu, Dong Liu, Ning Hu, Diming Zhang
Summary: Researchers have developed a colorimetric plate reader based on smartphones and tablets, which has intelligent and dynamic light modulation capabilities. Compared to traditional plate readers and smartphone-based systems, this system exhibits higher sensitivity, lower detection limits, and broader detection ranges.
Article
Engineering, Biomedical
Phillip Won, Stephen Coyle, Seung Hwan Ko, David Quinn, K. Jimmy Hsia, Philip LeDuc, Carmel Majidi
Summary: Liquid metal embedded elastomers (LMEEs) are stretchable composites with unique properties that make them appealing for flexible electronics and soft robotics. This study investigates the biocompatibility and cell cytotoxicity of LMEE composites in contact with C2C12 cells. The influence of EGaIn volume ratio and synthesis parameters on cell proliferation and viability is examined, as well as the case of electrically-conductive LMEE composites.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Mechanical
Weicheng Huang, Mingchao Liu, K. Jimmy Hsia
Summary: A numerical framework based on discrete differential geometry (DDG) is used to analyze the dynamics of bio-inspired cilia carpet robots powered by an external magnetic field. The model accurately captures the behavior of the active cilia and the carpet, and provides insights for the optimal design of cilia-inspired soft robots for biomedical applications. The framework is computationally efficient and can simulate dynamic locomotion such as crawling and rolling. (c) 2023 Elsevier Ltd. All rights reserved.
EXTREME MECHANICS LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Jiaru Fang, Yuxiang Pan, Jiarong Xu, Dongxin Xu, Hongbo Li, Chuan Liu, Ning Hu
Summary: An integrated cardiomyocyte-based biosensing platform has been developed to record action potential and evaluate the quality of electroporation. This platform shows potential for drug delivery therapy and pathology research in cardiology.
Article
Chemistry, Multidisciplinary
Kai Zhu, Tao Yan, Chunlian Qin, Yuxiang Pan, Jun Li, Hao Lai, Dongxin Xu, Chunsheng Wang, Ning Hu
Summary: This study presents the development of a three-dimensional cardiomyocyte-nanobiosensing system that can specifically recognize drug subgroups, providing an accurate and sensitive platform for drug screening in cardiovascular diseases.
Article
Engineering, Mechanical
Weicheng Huang, Mingchao Liu, K. Jimmy Hsia
Summary: Hard-magnetic soft materials and structures have attracted wide attention in various engineering applications due to their rapid configurational transformation under non-contact magnetic stimuli. Predicting their mechanical responses is crucial for realizing their full potentials. In this work, we propose a discrete magneto-elastic rod model to analyze the mechanical behaviors of slender structures made of HMS materials. The model considers the dipole-dipole interaction and viscous effect and significantly improves the computational efficiency for simulating the mechanical, especially dynamic, behaviors of hard-magnetic slender structures.
EXTREME MECHANICS LETTERS
(2023)
Article
Chemistry, Analytical
Ning Hu, Hao Wan
Article
Multidisciplinary Sciences
Luyi Feng, Tiankai Zhao, Hongmei Xu, Xuechen Shi, Changhao Li, K. Jimmy Hsia, Sulin Zhang
Summary: The ability of cells to sense and adapt to curvy topographical features is important for organ morphogenesis, tissue repair, and tumor metastasis. This study reveals a mechanism in which surface tension can activate different cell migration modes depending on the curvature. The findings suggest that multicellular curvature sensing is more efficient and may provide insights into collective patterns and functions of living active systems.
Article
Nanoscience & Nanotechnology
Xingxing Liu, Dongxin Xu, Jiaru Fang, Yuheng Liao, Mingyue Zhang, Hongbo Li, Wenjian Yang, Yue Wu, Zhongyuan Xu, Ning Hu, Diming Zhang
Summary: With the development of micro/nanotechnologies, researchers have developed multielectrode arrays (MEAs) with different three-dimensional (3D) micro/nanostructures for intracellular action potential recording of cardiomyocytes. However, the effect of 3D micro/nanostructure density on intracellular recording has not been fully explored. In this study, 3D tunable nanodensity electrode arrays (TNDEA) were fabricated to investigate the impact of nanodensity regulation on intracellular biosensing. The low-nanodensity TNDEA achieved improved signal quality of intracellular potentials, including amplitude, signal-to-noise ratio (SNR), recording duration, and recording yield, compared to the high-nanodensity TNDEA. This 3D nanodensity regulating strategy has the potential to serve as a powerful electrophysiological research tool in the biomedical field.
Review
Nanoscience & Nanotechnology
Yi Zhang, Ning Hu, Jiajie Xu, Zhen Wang
Summary: DNA programming, based on base complementary pairing and Boolean operations, has practical applications in multidisciplinary cutting-edge research. DNA logic circuits play a crucial role in biomedical fields, enabling autonomous assessment and stable visual signal outputs.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
