Article
Chemistry, Analytical
HuanWen Han, Kazuyuki Nobusawa, Ichiro Yamashita
Summary: The DNA intercalator [Ru(bpy)(2)DPPZ](2+) was found to significantly increase charge transfer in electrochemical impedance spectroscopy (EIS), making it a promising candidate for applications in dsDNA detection or PCR monitoring. Future developments may lead to EIS sensors that do not require specific electrode modifications.
ANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Amin Moradpour, Manuel Kasper, Johannes Hoffmann, Ferry Kienberger
Summary: This paper presents a comprehensive uncertainty analysis of calibrated electrochemical impedance spectroscopy (EIS) for batteries, aiming to identify the effect of fixture repeatability and measurement noise on the measured impedances. A specific error model is assigned to each uncertainty source, and the model parameters' real and imaginary parts are characterized through impedance measurements. The errors are propagated through the calibration and correction functions, and the resulting uncertainty is shown as ellipsoids in the Nyquist plot.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2022)
Article
Engineering, Electrical & Electronic
Leila Es Sebar, Leonardo Iannucci, Emma Angelini, Sabrina Grassini, Marco Parvis
Summary: This article presents a portable low-cost device for electrochemical impedance spectroscopy (EIS) measurements based on TeensyDuino, eliminating the need for additional components. The instrument can measure impedance over a wide frequency range and has a low uncertainty level.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Materials Science, Multidisciplinary
V. Bongiorno, S. Gibbon, E. Michailidou, M. Curioni
Summary: This study explores the potential use of machine learning algorithms to interpret electrochemical impedance spectroscopy (EIS) data, focusing on classification and fitting scenarios. The traditional approach based on equivalent circuit modeling is difficult to automate and has limited industrial applications.
Article
Chemistry, Analytical
Hend S. Magar, Rabeay Y. A. Hassan, Ashok Mulchandani
Summary: Electrochemical impedance spectroscopy (EIS) is a powerful technique for analyzing interfacial properties related to bio-recognition events at the electrode surface, with applications in biomedical diagnosis and environmental monitoring. The use of nanomaterials enhances the analytical features of impedimetric biosensors, promoting faster electron transfer and improving sensor reliability and accuracy.
Article
Energy & Fuels
Mohammad Abareshi, Erfan Sadeghi, Mohsen Hamzeh, Mehrdad Saif, Seyed Mohammad Mahdi Alavi
Summary: This paper proposes a multi-purpose controllable electrochemical impedance spectroscopy (MP-cEIS) device for battery monitoring and testing during charge and discharge processes. The device is based on a synchronous buck converter with a low-cost input filter and includes a closed-loop feedback system for controlling the injection of the EIS excitation signal. The design of a robust controller using H-infinity and quantitative feedback theory (QFT) methods is also presented.
JOURNAL OF ENERGY STORAGE
(2022)
Article
Chemistry, Analytical
Ching-Yu Lin, Uyen Thi Nhat Nguyen, Han-Yun Hsieh, Hidetoshi Tahara, Yu-Sheng Chang, Bing-Yu Wang, Bing-Chen Gu, Yu-Han Dai, Chia-Che Wu, I-Jung Tsai, Yu-Jui Fan
Summary: The study developed a peptide-based electrochemical sensor for detecting autoantibodies in rheumatoid arthritis. The new method showed better sensitivity and accuracy compared to the traditional anti-CCP ELISA method.
Review
Materials Science, Multidisciplinary
Zi-Bo Chen, Hui-Hui Jin, Zhu-Gen Yang, Da-Ping He
Summary: Metal-based nanomaterials have a wide range of applications, and this review focuses on their use in electrochemical impedance spectroscopy (EIS) biosensors for medical healthcare, environmental monitoring, and food safety. The review discusses the importance of bioreceptors and metal nanomaterials in the design and function of these biosensors, and provides insights for future development.
Review
Energy & Fuels
Erfan Sadeghi, Mohammad Mahdi Gholami, Mohsen Hamzeh, Seyed Mohammad Mahdi Alavi, Mehrdad Saif
Summary: With the automotive industry's shift towards electric vehicles and the consequent reliance on energy storage systems, the interest in Power Electronics Interfaced Electrochemical Impedance Spectroscopy (PEI-EIS) is rapidly growing. This paper provides an engineering perspective on the PEI-EIS process, guiding researchers through the main phases, reviewing recent work, and highlighting the challenging issues encountered. It discusses the often overlooked role of the controller, the generation of required excitation signals by power electronics devices, the type of excitations needed, data measurement, and result presentation. Furthermore, it evaluates the pros and cons of past contributions to PEI-EIS from an engineering viewpoint.
JOURNAL OF ENERGY STORAGE
(2023)
Article
Infectious Diseases
Fred C. Tenover, Isabella A. Tickler
Summary: The application of molecular detection methods has greatly improved the outcomes of septic patients with MRSA infections. However, the accuracy of molecular tests may be affected by the presence of other staphylococcal species and genetic mutations. Phenotypic methods should be considered when resolving discrepancies between genotypic and phenotypic results.
Article
Microbiology
Marwa A. Abdelwahab, Wesam H. Amer, Dalia Elsharawy, Reham M. Elkolaly, Rehab Abd El Fattah Helal, Dina Ahmed El Malla, Yomna G. Elfeky, Hebatallah A. Bedair, Rania S. Amer, Marwa E. Abd-Elmonsef, Marwa S. Taha
Summary: Methicillin-resistant Staphylococci, primarily encoded by the mecA gene, is a significant public health concern. The mecC gene, a new mecA analog, is responsible for methicillin resistance in certain clinical Staphylococcal isolates, but its prevalence in Egypt is still underestimated. The aim of this study was to detect the mecA and mecC genes in clinical Staphylococci isolates from a tertiary care university hospital in Egypt, comparing different phenotypic methods.
Article
Engineering, Electrical & Electronic
Lignesh Durai, Sushmee Badhulika
Summary: The study reported an ultra-selective biosensor for fibrinogen detection using AlFeO3 nanospheres modified screen-printed carbon electrode, which exhibited excellent selectivity and sensitivity. The sensor has a low limit of detection and is suitable for detecting both deficiency and excess levels of fibrinogen in human blood.
IEEE SENSORS JOURNAL
(2021)
Article
Materials Science, Multidisciplinary
Naseem Akhtar, Malika Rani, Arshad Mahmood, Kashmala Tariq, G. Murtaza, Asma A. Alothman, Rahaf S. AL-zahrani, Sajid Ali, Naveed Kasuar Janjua, Aqeel Shah
Summary: This work successfully synthesized NaCr2O4/GO nanocomposite using co-precipitation method for energy storage applications. Characterizations such as SEM and XRD were performed to investigate the optical and structural properties. The nanocomposite showed reduced crystalline size and high specific capacitance, making it suitable for various applications.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Chemistry, Physical
Davood Peyrow Hedayati, Gita Singh, Michael Kucher, Tony D. Keene, Robert Boehm
Summary: This study aims to improve the performance of solid-state supercapacitors (SSCs) by simulating their impedance using a defined equivalent circuit (EC) model. Two models, a mathematical model and a physicochemical model, were used and the impedance was measured using electrochemical impedance spectroscopy (EIS). The physicochemical model showed higher approximation ability due to its more complex circuit design, but also required more modeling and optimization effort.
Article
Microbiology
Kyle A. Hess, Kirstin Kooda, Joshua D. Shirley, Audrey N. Schuetz, Omar Abu Saleh, Ryan W. Stevens
Summary: Genotypic testing for mecA/mecC is crucial for optimizing antimicrobial therapy in Staphylococcus aureus infections. However, little is known about the optimal reporting and therapy for patients with phenotypic oxacillin resistance but lacking genotypic evidence of mecA or mecC.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Chemistry, Analytical
Perrine Lasserre, Banushan Balansethupathy, Vincent J. Vezza, Adrian Butterworth, Alexander Macdonald, Ewen O. Blair, Liam McAteer, Stuart Hannah, Andrew C. Ward, Paul A. Hoskisson, Alistair Longmuir, Steven Setford, Eoghan C. W. Farmer, Michael E. Murphy, Harriet Flynn, Damion K. Corrigan
Summary: Diagnostic practices for SARS-CoV-2 involve qPCR-based nucleic acid amplification or antigen-based tests. qPCR has high sensitivity but is time-consuming and requires expensive equipment and expertise. LFAs are low-cost and near real-time, but have lower sensitivity and are mostly qualitative. This study presents an antigen-based electrochemical aptamer sensor that can quickly detect SARS-CoV-2 in a simple measurement format.
ANALYTICAL CHEMISTRY
(2022)
Article
Biophysics
Eva Gonzalez-Fernandez, Matteo Staderini, Jamie R. K. Marland, Mark E. Gray, Ahmet Ucar, Camelia Dunare, Ewen O. Blair, Paul Sullivan, Andreas Tsiamis, Stephen N. Greenhalgh, Rachael Gregson, Richard Eddie Clutton, Stewart Smith, Jonathan G. Terry, David J. Argyle, Anthony J. Walton, Andrew R. Mount, Mark Bradley, Alan F. Murray
Summary: The study introduced a miniaturised, self-contained electrochemical pH sensor system using a methylene blue redox reporter, which demonstrated remarkable robustness, accuracy, and sensitivity. The sensor effectively tracked real-time intratumoral tissue pH changes in vivo, correlating well with laboratory blood tests.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemical Research Methods
Maiwenn Kersaudy-Kerhoas, Antonio Liga, Appan Roychoudhury, Marilena Stamouli, Rhiannon Grant, Damaso Sanchez Carrera, Holger Schulze, Witold Mielczarek, Wilna Oosthuyzen, Juan F. Quintana, Paul Dickinson, Amy H. Buck, Nicholas R. Leslie, Jurgen Haas, Till T. Bachmann, James W. Dear
Summary: Drug-induced liver injury (DILI) is a major cause of hospital attendance and financial loss, and miR-122 has been suggested as a potential marker for DILI. However, the measurement of circulating miRNAs at point of care is time-consuming and expensive. This study presents a novel microfluidic platform for the extraction of miR-122 from blood, which demonstrates comparable or better performance than standard extraction kits. The platform, combined with electrochemical impedance spectroscopy, shows potential for point-of-care detection of miR-122, providing a standardized and low-cost method for miRNA-based assays.
Article
Engineering, Electrical & Electronic
Iremnur Akcakoca, Hamed Ghorbanpoor, Ewen Blair, Yasin Ozturk, Araz Norouz Dizaji, Tanil Kocagoz, Huseyin Avci, Damion Corrigan, Fatma Dogan Guzel
Summary: This study developed a microheater to enhance the sensitivity of nucleic acid hybridization detection, paving the way for the development of highly sensitive and specific integrated label-free biosensors.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Engineering, Electrical & Electronic
Hamed Ghorbanpoor, Araz Norouz Dizaji, Iremnur Akcakoca, Ewen O. Blair, Yasin Ozturk, Paul Hoskisson, Tanil Kocagoz, Huseyin Avci, Damion K. Corrigan, Fatma Dogan Guzel
Summary: The study aimed to develop a rapid, simple, cost-effective and comprehensive antibiotic susceptibility/resistance test using a microfluidic chip called 'MycoCHIP'. Through integrating a microelectrode sensor, it successfully detected nucleic acid sequences of Mycobacterium smegmatis and distinguished antibiotic-incubated cells from non-incubated cells. This approach showed potential for quicker, reliable and more economically determining antibiotic susceptibility compared to current methods.
SENSORS AND ACTUATORS A-PHYSICAL
(2022)
Article
Biochemical Research Methods
Alexander R. Macdonald, Francessca Charlton, Damion K. Corrigan
Summary: In this study, researchers functionalised an implantable stereo-electroencephalography (sEEG) depth electrode with an enzyme coating for enzyme-based biosensing of glucose and L-glutamate. Through characterisation using various electrochemical methods, they demonstrated that the modified electrode exhibited good electrochemical response and sensitivity to glucose and L-glutamate concentration, providing more accurate information for the treatment of neurological disorders. The findings suggest that existing clinical electrode devices can be adapted for combined electrochemical and electrophysiological measurements, accelerating the application of in vivo and wearable biosensing for diagnosis, treatment, and personalised medicine.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Hamed Ghorbanpoor, Iremnur Akcakoca, Araz Norouz Dizaji, Adrian Butterworth, Damion Corrigan, Tanil Kocagoz, Aliakbar Ebrahimi, Huseyin Avci, Fatma Dogan Guzel
Summary: It is estimated that one quarter of the global population is latently infected by Mycobacterium tuberculosis (TB), with 1 in 10 going on to develop active disease. Low-cost and easy-to-use technological solutions are critical for diagnosis and prescribing practice for TB in low- and middle-income countries. This study presents a low-cost and simple-to-use AST sensor that can detect drug susceptibility of M. tuberculosis in 96 hours.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Thermodynamics
Jionghui Liu, Daniel Orejon, Ningxi Zhang, Jonathan G. Terry, Anthony J. Walton, Khellil Sefiane
Summary: This study investigates the bubble dynamics during pool boiling from isolated cavities on a horizontal silicon substrate with different surface coatings. Vertical coalescence occurs at lower superheat degrees on Perfluorodecyltrichlorosilane coated surfaces due to faster initial bubble growth. However, vertical coalescence has limited effect on bubble departure diameter. Bubbles growing on silica nanoparticles coated surface can coalesce for small cavity spacing with lower superheat degree, and optimal heat transfer performance may be achieved when the cavities spacing is approximate to the single bubble departure diameter.
HEAT TRANSFER ENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Paul Williamson, Petteri Piskunen, Heini Ijas, Adrian Butterworth, Veikko Linko, Damion K. Corrigan
Summary: Electrochemical DNA (e-DNA) biosensors are effective tools for disease monitoring, as they can translate hybridization events into recordable electrical signals. In this study, a strategy for amplifying electrochemical signals associated with DNA hybridization was reported using DNA origami method, leading to an improved sensor limit of detection and high strand selectivity. This approach could address the sensitivity requirements for low-cost point-of-care devices.
Article
Biochemical Research Methods
Raquel Sanchez-Salcedo, Rebeca Miranda-Castro, Noemi de-los-Santos-Alvarez, Maria Jesus Lobo-Castanon, Damion K. Corrigan
Summary: A capacitive electrochemical impedance spectroscopy sensing platform tailored for point-of-care detection and treatment monitoring has been developed. The specific recognition of IL-6 was achieved using an anti-IL-6 nanobody or a specific IL-6 aptamer. The results provide useful information for the future design of low-cost and wearable impedance biomarker detection platforms.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Magdalena R. R. Raykova, Katie McGuire, William J. J. Peveler, Damion K. K. Corrigan, Fiona L. L. Henriquez, Andrew C. C. Ward
Summary: Tetracycline antibiotics are widely used in veterinary medicine but are eliminated unmodified from animals through excretion routes. Residues secreted in milk are strictly controlled in dairy animals. In this study, an electrochemical detection method for tetracycline residues was developed using the metal chelation properties of tetracyclines. The method showed good sensitivity and specificity in detecting tetracycline in buffer media and milk samples with minimal sample preparation.
Proceedings Paper
Engineering, Electrical & Electronic
Alan W. S. Ross, Coinneach M. Dover, Stewart Smith, Jonathan G. Terry, Andrew R. Mount, Anthony J. Walton
Summary: This paper presents a previously documented full wafer test structure to evaluate the effect of seed layer thickness and conductivity on the plating uniformity of patterned electroplated structures. The results demonstrate that by adjusting the current distribution structures, significant improvement in wafer plating uniformity can be achieved when using seed layer thicknesses of a few nanometers.
2022 IEEE 34TH INTERNATIONAL CONFERENCE ON MICROELECTRONIC TEST STRUCTURES (ICMTS)
(2022)
Proceedings Paper
Engineering, Electrical & Electronic
Camelia Dunare, Shan Zhang, Jamie R. K. Marland, Andreas Tsiamis, Paul Sullivan, Ian Underwood, Jonathan G. Terry, Anthony J. Walton, Stewart Smith
Summary: In order to produce robust and reliable micro-scale integrated electrochemical sensors, a stable reference electrode such as a silver/silver chloride (Ag/AgCl) electrode is needed. The preparation process of the Ag/AgCl electrode requires a good understanding and controlled processes to ensure stability.
2022 IEEE 34TH INTERNATIONAL CONFERENCE ON MICROELECTRONIC TEST STRUCTURES (ICMTS)
(2022)
Article
Biotechnology & Applied Microbiology
Carla Lopez, Magdalena R. Raykova, Damion K. Corrigan, Charles W. Knapp, Andrew C. Ward
Summary: This study explores a low-cost method for detecting antimicrobial residues in the environment. A microbial bioassay was developed based on the metabolic response of Geobacillus stearothermophilus. It was found that adding chloramphenicol to the media can increase the sensitivity of the assay, providing a promising basis for future low-cost sensor development.
SENSORS AND ACTUATORS REPORTS
(2022)
Article
Chemistry, Analytical
Roger Domingo-Roca, Alexander R. Macdonald, Stuart Hannah, Damion K. Corrigan
Summary: 3D printing has become an important tool in many research areas, including biosensing. By using multi-material 3D printing technology, we have successfully produced a compact electrochemical sensor that can operate efficiently with only 100 μL of sample. We tested the performance and sensitivity of the sensor, and investigated the influence of print orientation and thickness on its electrochemical performance.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
