Article
Multidisciplinary Sciences
Ning Zhou, Yuxin Yang, Xin Guo, Jue Gong, Zhangxing Shi, Zongyin Yang, Hao Wu, Yixiao Gao, Ni Yao, Wei Fang, Pan Wang, Limin Tong
Summary: This study reports the direct observation of lasing in microfiber-coupled single plasmonic nanoparticles enabled by strong mode coupling. The results show that single-mode laser emission from the nanoparticles can be achieved at room temperature with low threshold and narrow linewidth.
Article
Pharmacology & Pharmacy
Yingying Zhang, Tiange Wang, Yu Tian, Chaonan Zhang, Kun Ge, Jinchao Zhang, Jin Chang, Hanjie Wang
Summary: The study presents an efficient synergistic immunotherapy based on gold nanorods platform for early diagnosis and treatment of post-surgical tumor recurrence. By incorporating fluorescence resonance energy transfer (FRET) technology and photothermal therapy (PTT), this approach showed promising results in inducing tumor cell death and increasing T-lymphocytes generation. The synergistic immunotherapy strategy also led to higher secretion of immune factors compared to mono-immunotherapy, providing a new perspective for basic and clinical research in the field.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Chemistry, Analytical
Meng-Qi He, Yongjian Ai, Wanting Hu, Xiaomeng Jia, Lei Wu, Mingyu Ding, Qionglin Liang
Summary: By using DNA as an etching agent, it is possible to control the morphology and optical properties of plasmonic nanoparticles, while also introducing fluorescence properties. This strategy allows for precise tuning of localized surface plasmon resonance (LSPR) and fluorescence-composited dual-mode signals.
ANALYTICAL CHEMISTRY
(2023)
Article
Nanoscience & Nanotechnology
Eitan Oksenberg, Ilan Shlesinger, Angelos Xomalis, Andrea Baldi, Jeremy J. Baumberg, A. Femius Koenderink, Erik C. Garnett
Summary: By monitoring the interfacial environment of a thousand single nanocavities with slightly varied resonance energies, an effective absorption spectrum of metal-bound molecules and a rich plasmon-driven chemistry landscape was constructed. The unavoidable energy losses associated with metals can carry valuable information on energy transfer to the adsorbed molecules. Using methylene blue as a model system, shifts in the absorption spectrum of molecules following surface adsorption were measured, revealing a rich plasmon-driven reactivity landscape with distinct reaction pathways occurring in separate resonance energy windows.
NATURE NANOTECHNOLOGY
(2021)
Article
Chemistry, Analytical
Huaichao Yi, Fengyi Lin, Xiaokun Wang, Jiaqi Su, Lijun Zhao, Sitong Lv, Ru Deng, Cuisong Zhou, Jianyuan Dai, Dan Xiao
Summary: A fluorescent labeling system based on the hybridization chain reaction (HCR) was developed for the determination of endonuclease activity. This system utilizes specially designed hairpin probes H1 and H2, which, upon triggering, undergo HCR to form long DNA nanowires containing intact cleavage sequences. The fluorescence signal is quenched in the absence of the endonuclease, but is recovered upon cleavage of the nanowires by the endonuclease. The detection limit of this system is 1.2 x 10(-4) U μL-1, and it can be easily adapted for the detection of other endonucleases by changing the cleavage sites.
ANALYTICAL LETTERS
(2023)
Article
Chemistry, Analytical
Mingmin Wu, Mengtian Zhang, Zhiwei Fan, Xinyue Qin, Xiaoxia Zhu, Haiwei Ji, Yuling Qin, Qi Wang, Li Wu
Summary: Sensitive detection of DNA methyltransferase activity using a new fluorescence transducer based on Forster resonance energy transfer (FRET) is presented, with high analytical performance and capability for enzyme inhibitor screening. The method offers a promising strategy for high-performance diagnosis, drug discovery, and treatment effectiveness evaluation in various disease-related methyltransferase activities.
Article
Chemistry, Analytical
Shiyu He, Hui Xiang, Gan Zhao, Mengting Zhang, Jian Lin, Lina Yang, Honglin Liu
Summary: Developing reliable probes for accurate monitoring peroxynitrite (ONOO-) in living systems is crucial for understanding its functions in diseases and improving therapies. In this study, a novel nano-assembly structure (D-AuGP) was developed using gold nanoclusters (Au NCs) and induced fluorescence resonance energy transfer (FRET). The probe showed a quantitative ratiometric fluorescence response toward ONOO- with good stability and biocompatibility. It was successfully used for biological imaging and monitoring ONOO- levels in living cells and zebrafish.
SENSORS AND ACTUATORS B-CHEMICAL
(2023)
Article
Chemistry, Physical
Ha Trang Nguyen, Thanh Thao Tran, Vishwa Bhatt, Manjeet Kumar, Ju-Hyung Yun
Summary: Hybrid nanostructures composed of quantum dots and metal nanoparticles have unique optical properties, and can be used to control photoluminescence in optoelectronic applications. By controlling the composition and size of the structure, the interaction between excitons and plasmon can be investigated, and the power conversion efficiency of silicon solar cells can be improved.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Analytical
Yayun Gu, Lizhong Peng, Weihua Ding, Yang Wang, Xuhui Zeng
Summary: In this study, a novel fluorescence resonance energy transfer (FRET) nanoprobe, AuNCs-LMWH-AuNRs, was developed for fast and sensitive monitoring of HPA enzymatic activity, which is crucial for searching for molecular therapies targeting HPA.
Article
Chemistry, Multidisciplinary
Spyridon Korkos, Kai Arstila, Kosti Tapio, Sami Kinnunen, J. Jussi Toppari, Timo Sajavaara
Summary: Shape modification of embedded nanoparticles by swift heavy ion (SHI) irradiation is an effective way to produce nanostructures with controlled size, shape, and orientation. Gold nanorods embedded in SiO2 and spherical metallic nanoparticles embedded in Al2O3 were irradiated with SHI. The nanorods re-oriented along the ion beam direction, while the nanoparticles elongated. Dark-field spectroscopy revealed two discrete peaks corresponding to longitudinal and transverse modes in the elongated nanoparticles.
Article
Agriculture, Multidisciplinary
Junyang Wang, Qian Zhang, Zheng Liu, Chuanyu Yang, Ying Li, Xinyue Ma, Ting Lv, Chunyan Sun
Summary: A simple and low-cost fluorescence signal-on sensing strategy based on functional nucleic acids (FNAs) has been developed for detecting analytes such as tetracycline and Pb2+. This strategy has excellent specificity and sensitivity, and has been successfully applied to detect contaminants in food and environmental samples.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Article
Biophysics
Jelena D. Pajovic, Radovan J. Dojcilovic, Slavka Kascakova, Matthieu Refregiers, Dusan K. Bozanic, Vladimir Djokovic
Summary: Functionalized gold nanoparticles using amino acid tryptophan and vitamin riboflavin showed enhanced resonance energy transfer (RET) efficiency, leading to a different photobleaching dynamics compared to molecules in solution. This effect was utilized for detection of the nanoparticles within autofluorescent biological material.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Chemistry, Physical
Guangchao Zheng, Sulin Jiao, Wei Zhang, Shenli Wang, Qinghua Zhang, Lin Gu, Weixiang Ye, Junjun Li, Xiaochen Ren, Zhicheng Zhang, Kwok-yin Wong
Summary: Accurate research on the applications of chiral plasmonic metal nanoparticles with surface plasmon resonance (SPR) still face challenges. This study demonstrates the production of chiral plasmonic metal nanoparticles with tunable chiroptical activities. The results show that the chiral properties can be precisely tailored by adjusting the longitudinal SPR (LSPR) and the amount of gold nanorods as seeds. The functionalization of a shell of another metal or semiconductor can also achieve a shift of the chiral properties within the UV-vis-NIR region. Chirality transfer from the gold core to the silver shell leads to new chiral properties in the near-UV region.
Article
Chemistry, Analytical
Xiu Qin, Chunling Yuan, Guoxing Geng, Rui Shi, Shiqi Cheng, Yilin Wang
Summary: An enzyme-free colorimetric method for sensitive detection of uric acid was established by inhibiting the etching of gold nanorods. The method achieved detection through UV-vis absorption spectra and visual observation, with a detection limit of 0.76 μM in low concentration range. This method has been successfully applied for determining uric acid in clinical samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Biochemical Research Methods
Mehavesh K. Hameed, Javad B. M. Parambath, Sofian M. Kanan, Ahmed A. Mohamed
Summary: Biocompatible and luminescent nanostructures synthesized by capping gold-carbon nanoparticles with amino acids were successfully utilized for the quantitative estimation of the drug ranitidine. The method showed a detection limit of 0.174, 0.56, and 0.332 mu M for different amino acid bioconjugates, and was also successful in quantifying ranitidine in spiked serum samples. The study demonstrates the potential of this approach for sensitive and accurate drug quantification.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
