Article
Nanoscience & Nanotechnology
Sivaranjani Devarakonda, Baskar Ganapathysubramanian, Pranav Shrotriya
Summary: The study presents an experimental and computational approach for developing a highly sensitive and responsive label-free biosensor based on aptamer-functionalized transparent electrode. The sensor shows sensitive and specific thrombin protein detection with a high signal-to-noise ratio. Computational and experimental results indicate that the sensing response is due to modified ionic transport under the combined influence of steric hindrance and surface charge modification.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
M-C Clochard, O. Oral, T. L. Wade, O. Cavani, M. Castellino, L. Medina Ligiero, T. Elan
Summary: This study reports the detection of Zn(II) in oil-polluted seawater using square-wave anodic stripping voltammetry (SW-ASV) with thin gold electrodes sputtered onto nanoporous poly(acrylic acid)-grafted-poly(vinylidene difluoride) (PAA-g-PVDF) membranes. The PAA grafted nanopores were found to efficiently trap Zn(II) ions. The SW-ASV protocol involved an accumulation step and a stripping step, and revealed the redox potential of Zn at -0.8 V. The calibration allowed for the determination of Zn(II) content in raw production water.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Nianyu Jiang, Pranav Shrotriya, Rohana P. Dassanayake
Summary: We report an NK-lysin peptide-functionalized NAAO biosensor for detecting bacterial endotoxin. NK-lysin NK2A exhibits antimicrobial activity against bacteria, and the protein-conjugated biosensor can detect the binding of LPS, leading to observable signals.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Peter Dobosy, Adam Illes, Anett Endredi, Gyula Zaray
Summary: Due to the increase in manufacture and recycling of lithium batteries, there may be a rise in lithium pollution in aquatic environments and drinking water reservoirs. A study was conducted in Hungary to investigate the levels of lithium in tap water samples from 19 different locations. The concentrations of lithium varied depending on the water source, with median values ranging from 3.52 to 8.55 μg/L. The study also assessed the levels of lithium in bottled mineral waters and found a median concentration of 17.8 μg/L.
SCIENTIFIC REPORTS
(2023)
Article
Biochemical Research Methods
Rosaceleste Zumpano, Manuela Manghisi, Francesca Polli, Cristine D'Agostino, Federica Ietto, Gabriele Favero, Franco Mazzei
Summary: This study developed a label-free electrochemical immunosensor for the quick, cheap, and straightforward determination of atrazine, achieving detection through a technological platform and specific treatment methods. Under optimal experimental conditions, the immunosensor exhibited good linearity range, limit of detection, reproducibility, and stability, making it suitable for successful application in the detection and monitoring of atrazine in real water samples.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Matias S. Netto, Jordana Georgin, Dison S. P. Franco, Evandro S. Mallmann, Edson Luiz Foletto, Marcelo Godinho, Diana Pinto, Guilherme L. Dotto
Summary: Hydrochar prepared from Prunus serrulata bark through hydrothermal treatment showed high adsorption efficiency for removing atrazine from river waters, with low cost and high efficacy.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Andreea Maria Iordache, Constantin Nechita, Ramona Zgavarogea, Cezara Voica, Mihai Varlam, Roxana Elena Ionete
Summary: This study assessed the contamination level of eight heavy metals and trace elements in the sediments of Olt River and found high levels of pollution primarily caused by anthropogenic factors. The results have important implications for assessing environmental and human health risks and informing freshwater management plans.
SCIENTIFIC REPORTS
(2022)
Article
Environmental Sciences
Shuangmei Tong, Linsheng Yang, Hongqiang Gong, Li Wang, Hairong Li, Jiangping Yu, Yonghua Li, Yangzong Deji, Cangjue Nima, Shengcheng Zhao, Zongji Gesang, Chang Kong, Xiaoya Wang, Zhuming Men
Summary: The study found that the concentrations of trace elements in drinking water and human urine in plateau region of China generally met the guideline values, with selenium contributing to the excretion of several elements in the body. Different trace elements showed associations with each other, and age and gender appeared to play a role in the excretion of trace elements.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Junyi Wu, Yan Zhang, Yu Tang
Summary: This study analyzed the removal effectiveness of MPs in a DWTP, showing that the removal efficiency for MPs <20pm needs improvement. The results indicate that more attention should be paid to the fragmentation of MPs and the removal rate of MPs <20pm in a DWTP.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biophysics
Jie Chen, Kai -Chun Lin, Shalini Prasad, David W. Schmidtke
Summary: In this paper, a novel label-free biosensor for real-time monitoring of acetylcholine was demonstrated. The sensor showed a linear relationship between acetylcholine concentration and Delta Zmod, and it remained responsive in complex environments and even after implantation in rat brain tissue.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
DRGKoppalu Puneeth R. Kumar, Zahid Manzoor Bhat, Sanjit Dey, Souvik Roy, Souvik Panda Mahapatra, Saikat Pahan, Musthafa Ottakam Thotiyl, Hosahudya N. Gopi
Summary: The development of miniaturized lab-on-chip devices for the detection of small molecule-protein interactions at low concentrations is of great importance in drug discovery and biomedicine. In this study, label-free detection of small molecule-protein interactions was achieved using nanoscale capacitance and impedance spectroscopy on surface functionalizable nanotubes of α, γ-hybrid peptide helical foldamers. The functionalizable hybrid peptide nanotubes enabled the label-free detection of various small molecule-protein interactions at very low concentrations.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Environmental
Yaser Rasouli, Raphael Maltais-Tariant, Benoit Barbeau, Mathieu Lapointe, Caroline Boudoux, Dominique Claveau-Mallet
Summary: Gravity-driven ceramic microfiltration membranes were synthesized using kaolin and different alumina contents. The effects of alumina content on the performance of river water filtration were evaluated. The results showed acceptable turbidity removal and high performance for DOC, UV, and alkalinity removal. The fouling mechanism transitioned from pore blocking to cake layer domination after the flux stabilization period. Increasing the alumina content increased the number of active microorganisms in the biofilm layer.
JOURNAL OF WATER PROCESS ENGINEERING
(2023)
Article
Chemistry, Analytical
Cheryl Suwen Law, Juan Wang, Satyathiran Gunenthiran, Siew Yee Lim, Andrew D. Abell, Lutz Ahrens, Tushar Kumeria, Abel Santos, Nicolas H. Voelcker
Summary: This study presents an optical system for real-time, label-free detection of per- and polyfluoroalkyl substances (PFASs). By analyzing key sensing parameters, the researchers determined the optimal molecular length for maximizing sensitivity and selectivity to PFAS. The study also provides insights into the formation mechanism of PFAS self-assembled monolayers, and demonstrates the potential real-life applicability of the system.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Environmental Sciences
Yaohuan Gao, Benjamin F. Trueman, Graham A. Gagnon
Summary: The study found that the addition of orthophosphate is more effective in controlling lead release compared to sodium silicate. Silicate treatment results in degradation of the top lead scale layer, leading to increased lead release. On the other hand, orthophosphate encourages the growth of structured and thicker corrosion scales, effectively limiting lead release.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Chemistry, Analytical
Gilberto J. Silva Junior, Jessica Soares Guimaraes Selva, Anandhakumar Sukeri, Josue M. Goncalves, Matias Regiart, Mauro Bertotti
Summary: In this work, nanoporous gold (NPG) was prepared using three different approaches, with the combined method showing the most surface defects, largest electrochemical surface area, and highest sensitivity for the detection of methyl parathion. The NPG(A+B) sensor demonstrated excellent selectivity, reproducibility, and repeatability for MP detection, with a linear behavior in the concentration range of 5-50 ng mL(-1) and a low limit of detection (LOD) of 0.6 ng mL(-1).
Article
Substance Abuse
Kai-Chun Lin, David Kinnamon, Devangsingh Sankhala, Sriram Muthukumar, Shalini Prasad
Article
Chemistry, Multidisciplinary
Hunter S. Stevenson, Shubrath S. Shetty, Noel J. Thomas, Vikram N. Dhamu, Ashlesha Bhide, Shalini Prasad
Article
Chemistry, Analytical
Antra Ganguly, Shalini Prasad
Article
Multidisciplinary Sciences
Hunter Stevenson, Amanda Bacon, Kathleen Mary Joseph, Wilma Ruth Wanjiku Gwandaru, Ashlesha Bhide, Devangsingh Sankhala, Vikram Narayanan Dhamu, Shalini Prasad
SCIENTIFIC REPORTS
(2019)
Article
Biochemical Research Methods
Antra Ganguly, Paul Rice, Kai-Chun Lin, Sriram Muthukumar, Shalini Prasad
Article
Chemistry, Analytical
Ivneet Banga, Anirban Paul, Sriram Muthukumar, Shalini Prasad
Article
Chemistry, Analytical
Abha Umesh Sardesai, Vikram Narayanan Dhamu, Anirban Paul, Sriram Muthukumar, Shalini Prasad
Article
Chemistry, Analytical
Isaac Macwan, Ashish Aphale, Prathamesh Bhagvath, Shalini Prasad, Prabir Patra
Article
Chemistry, Analytical
Antra Ganguly, Tahmineh Ebrahimzadeh, Philippe E. Zimmern, Nicole J. De Nisco, Shalini Prasad
Summary: The developed lateral flow electrochemical biosensor uses nanoconfinement technology to rapidly and accurately diagnose urinary tract infections, showing superior specificity and accuracy compared to commercial test strips. This has the potential to improve treatment success rates and reduce costs.
Article
Chemistry, Analytical
Antra Ganguly, Varun Gunda, Kevin Thai, Shalini Prasad
Summary: This work proposes a novel diagnostic biosensor that can stratify disease states based on severity, enabling clear and actionable diagnoses. The biosensor utilizes electrochemical impedance spectroscopy for fast detection and can work with any combination of disease biomarkers for accurate classification. The proposed scheme incorporates a machine learning model for disease classification with high accuracy.
Article
Chemistry, Analytical
Sarah Shahub, Kai-Chun Lin, Sriram Muthukumar, Shalini Prasad
Summary: This work demonstrates the use of a noninvasive, sweat-based dual biomarker electrochemical sensor for continuous monitoring of Traumatic Brain Injury (TBI) and inflammation response. The sensor was able to detect GFAP and IL-6 in sweat and showed potential for better management of TBIs.
Article
Chemistry, Analytical
Mohammed A. A. Eldeeb, Vikram Narayanan Dhamu, Anirban Paul, Sriram Muthukumar, Shalini Prasad
Summary: Sustainable agriculture is the solution to the environmental challenges caused by the increasing food demand. A new ion-selective electrode (ISE) electrochemical soil nitrate sensor has been developed for real-time and continuous measurement without soil pretreatment. The sensor showed high accuracy and performance across different soil textures, and it was capable of measuring soil nitrate in a dynamic manner. The validation tests demonstrated its reliability for various soil types.
Article
Medicine, Research & Experimental
Paul Rice, Sayali Upasham, Badrinath Jagannath, Roshan Manuel, Madhavi Pali, Shalini Prasad
Article
Chemistry, Analytical
Ashlesha Bhide, Sarah Cheeran, Sriram Muthukumar, Shalini Prasad
Article
Chemistry, Analytical
Sayali Upasham, Serena Bhadsavle, Shalini Prasad
ANALYTICAL METHODS
(2019)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
