Article
Chemistry, Analytical
HuanWen Han, Kazuyuki Nobusawa, Ichiro Yamashita
Summary: The DNA intercalator [Ru(bpy)(2)DPPZ](2+) was found to significantly increase charge transfer in electrochemical impedance spectroscopy (EIS), making it a promising candidate for applications in dsDNA detection or PCR monitoring. Future developments may lead to EIS sensors that do not require specific electrode modifications.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Physical
Veronika Pinkova Gajdosova, Lenka Lorencova, Anna Blsakova, Peter Kasak, Tomas Bertok, Jan Tkac
Summary: The review discusses the challenges and solutions for the successful design of impedimetric biosensors for highly sensitive affinity detection of proteins, including the effects of gold etching, ionic strength, interface properties, and analyte:bioreceptor ratio. Additionally, it touches on other factors like conductive interfaces, small bioreceptors, and strategies for improved selectivity and sensitivity.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Engineering, Electrical & Electronic
Sammy A. Perdomo, Viviana Ortega, Andres Jaramillo-Botero, Nelson Mancilla, Jose Hernando Mosquera-DeLaCruz, Drochss Pettry Valencia, Mauricio Quimbaya, Juan David Contreras, Gabriel Esteban Velez, Oscar A. Loaiza, Adriana Gomez, Jhonattan de la Roche
Summary: One critical step to solving the SARS-CoV-2 pandemic is to stop its spread by detecting and isolating asymptomatic individuals infected with the virus. Unfortunately, current rapid testing tools lack the ability for early detection. SenSARS is an accurate, portable, and low-cost medical device that offers real-time diagnostics and viral load tracking capabilities.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2021)
Article
Nanoscience & Nanotechnology
Miklos Csontos, Yannik Horst, Nadia Jimenez Olalla, Ueli Koch, Ivan Shorubalko, Andras Halbritter, Juerg Leuthold
Summary: The resistance state of filamentary memristors can be adjusted by relocating a few atoms in the active region of the conducting filament. The technology shows promise in downsizing, energy efficiency, and speed. However, the mechanisms and limitations of ultra-fast resistive switching need to be clarified for high-frequency applications. In this study, bipolar, multilevel resistive switchings were investigated in tantalum pentoxide based memristors with picosecond time resolution.
ADVANCED ELECTRONIC MATERIALS
(2023)
Review
Engineering, Electrical & Electronic
Desiree Santano Rivero, Aitor Urrutia, Carlos Ruiz-Zamarreno, Ignacio Del Villar
Summary: DNA is playing an increasingly important role in the field of optical fiber sensors, serving as both a biosensing tool and a detection target. This review highlights recent advancements in utilizing natural and synthetic DNA receptors for detection, while analyzing parameters such as sensitivity, detection range, and limit of detection to compare different technologies and explore future research directions in fiber optic DNA-based sensors.
IEEE SENSORS JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Irina Georgiana Munteanu, Constantin Apetrei
Summary: The screening and quantification of antioxidants from biological samples is essential for human health, and electrochemical sensors and biosensors show promising potential in antioxidant research, providing fast, economical, and reliable analytical methods for their detection.
Review
Chemistry, Multidisciplinary
Simona Ranallo, Sara Bracaglia, Daniela Sorrentino, Francesco Ricci
Summary: This Perspective provides a critical overview of recent research efforts on the development and characterization of synthetic antigen-conjugated DNA strands responsive to specific antibodies. These systems have potential applications in sensing, drug-delivery, and antibody-antigen binding characterization. The examples demonstrate how synthetic nucleic acids can be used to create innovative analytical tools and target-responsive systems.
Article
Chemistry, Multidisciplinary
Ferry Anggoro Ardy Nugroho, Dominika Switlik, Antonius Armanious, Padraic O'Reilly, Iwan Darmadi, Sara Nilsson, Vladimir P. Zhdanov, Fredrik Hook, Tomasz J. Antosiewicz, Christoph Langhammer
Summary: This paper presents a dual-band nanoplasmonic ruler that enables real-time simultaneous measurements of thickness and refractive index variations in uniform and heterogeneous layers, as well as tracking shape changes of nanostructures. The ruler offers sub-nanometer resolution and label-free operation, making it an important tool for nanobiological research and applications.
Article
Agriculture, Dairy & Animal Science
Paul Dawson, Ahmet Buyukyavuz, Claudia Ionita, Julie Northcutt
Summary: The combination of PCR and DNA extraction techniques can be used to enumerate Campylobacter spp. from poultry gastrointestinal tract samples. The study developed a DNA standard curve for Campylobacter spp. DNA primers and a cell/genomic DNA extraction protocol for complex samples. The results showed that qPCR and standard plate count methods were highly correlated for enumerating Campylobacter spp. in the specified range.
Article
Chemistry, Analytical
Georgeena Mathew, Miriam Daniel, Karthik Peramaiah, Munuswamy-Ramanujam Ganesh, Bernaurdshaw Neppolian
Summary: Metal-organic frameworks (MOFs) are widely used as supporting materials for electrochemical sensing applications. In this study, Ag nanoparticles were incorporated into a Bi-BDC MOF and used for the detection of hydrogen peroxide (H2O2). The Ag-Bi-BDC MOF showed excellent electrocatalytic activity towards H2O2 detection, thanks to the strong binding interaction of Bi3+ with H2O2, the high porosity of the MOF, and the catalytic activity of Ag particles. The fabricated sensor exhibited a wide linear range, high sensitivity, short response time, and low detection limit for H2O2, as well as good selectivity, stability, and reproducibility. The sensor also showed promising real-time application in detecting H2O2 secreted from cancer cells.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Analytical
Pavan Kumar Mandali, Amrish Prabakaran, Kasthuri Annadurai, Uma Maheswari Krishnan
Summary: Glycated hemoglobin (HbA1c) is a biomarker for diabetes, measuring long-term glycemic status. Traditional techniques for measuring HbA1c are time-consuming and expensive. Nanostructured sensors have been developed to improve specificity and accuracy. This review discusses recent advances in electrochemical detection for HbA1c and the challenges in developing cost-effective point-of-care devices.
Article
Instruments & Instrumentation
Annalisa De Pastina, Francesco Padovani, Giulio Brunetti, Chiara Rotella, Fabio Niosi, Victor Usov, Martin Hegner
Summary: The study presents a nanomechanical platform for real-time quantitative label-free detection of target biomolecules in a liquid environment with high mass sensitivity. By implementing a new measurement strategy, the detection limit is enhanced by a factor of 7 and the time resolution is increased by more than threefold. The proof-of-concept experiment demonstrates the feasibility of immobilization and label-free in situ detection of live bacterial cells using this platform.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2021)
Article
Chemistry, Analytical
Chunsheng Wu, Ping Zhu, Yage Liu, Liping Du, Ping Wang
Summary: Biological chemical sensing systems, such as olfactory and taste systems, have evolved over millions of years to become highly powerful in detecting and discriminating various chemical substances. Developing field-effect sensors using biomaterials for chemical sensing has broad applications but is also challenging. Recent advances in this area have shown promising prospects and potential applications, although there are still limitations and challenges to address in the future.
Article
Chemistry, Analytical
Franziska Schlenker, Elena Kipf, Nadine Borst, Tobias Hutzenlaub, Roland Zengerle, Felix von Stetten, Peter Juelg
Summary: Multiplexing of analyses is crucial for reducing sample and reagent consumption in applications with a large target panel. By combining photobleaching-sensitive and photobleaching-resistant fluorophores, the degree of multiplexing per channel can be doubled. This study demonstrates the potential for utilizing virtual fluorescence color channels, in addition to standard channels, in cancer diagnostics utilizing mediator probe PCR and UR fluorogenic oligonucleotides. The high sensitivity of the method is confirmed through a LOD analysis, showcasing the potential for creating virtual channels with optimal fluorogenic reporter combinations for high degree of multiplexing at low technical effort.
ANALYTICAL CHEMISTRY
(2021)
Review
Materials Science, Multidisciplinary
Yui Sasaki, Tsuyoshi Minami
Summary: This article reviews the methodologies and actual approaches to maximizing the potential of organic field-effect transistors (OFETs) as chemical sensor platforms through fusion technologies between organic electronics and molecular-recognition chemistry. Functionalized extended-gate-type OFETs have achieved real-sample analysis, indicating the acceleration of the establishment of practical chemical sensor devices through the interdisciplinary field of organic electronics and molecular-recognition chemistry.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Diana Gaspar, Jorge Martins, Jose Tiago Carvalho, Paul Grey, Rogerio Simoes, Elvira Fortunato, Rodrigo Martins, Luis Pereira
Summary: The market for flexible, hybrid, and printed electronic systems is uncertain, but these systems are emerging daily, allowing for devices and systems that can be folded and stored in pockets. Cellulose-based modified nanopapers were developed as a physical support and gate dielectric layer for recyclable field-effect transistors (FETs). Impregnation of the nanopapers with sodium ions enabled low voltage FETs (<3 V), with high mobility (>10 cm2 V-1 s-1), current modulation (>105), and improved dynamic response. These transistors were successfully implemented into simple circuits such as inverters, showing clear discrimination between logic states. Besides improved electrical performance, these devices are a promising alternative for reliable, sustainable, and flexible electronics, even under stress conditions.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Energy & Fuels
Paulo Joaquim Nunes, Rui Francisco Pinto Pereira, Sonia Pereira, Maria Manuela Silva, Elvira Fortunato, Veronica de Zea Bermudez, Mariana Fernandes
Summary: Two di-ureasils with oxyethylene segments were prepared by the sol-gel method, doped with ionic liquid and lithium salt. The resulting films were translucent, flexible, hydrophobic, and had low surface roughness. The optimized sample exhibited good ionic conductivity and was used in prototype electrochromic devices with promising performance.
Article
Chemistry, Multidisciplinary
Ana Pinheiro, Andreia Ruivo, Joao Rocha, Marta Ferro, Joana Vaz Pinto, Jonas Deuermeier, Tiago Mateus, Ana Santa, Manuel J. J. Mendes, Rodrigo Martins, Sandra Gago, Cesar A. T. Laia, Hugo Aguas
Summary: The present study aims to enhance the performance of solar cells by developing advanced luminescent down-shifting using encapsulated nanostructured perovskite materials. Thin films of CsPbBr3 perovskite nanocrystal luminophores were synthesized and encapsulated with parylene type C to protect and stabilize the films. The results showed that this encapsulation technique significantly improved the current generation and spectral response of the photovoltaic cells.
Article
Biochemical Research Methods
Beatriz B. Oliveira, Beatriz Costa, Barbara Morao, Sandra Faias, Bruno Veigas, Lucilia Pebre Pereira, Cristina Albuquerque, Rui Maio, Marilia Cravo, Alexandra R. Fernandes, Pedro Viana Baptista
Summary: The success of personalized medicine relies on biomarker discovery for identifying patients who will benefit from specific targeted drugs. Liquid biopsies, particularly the analysis of circulating tumor DNA, are emerging as a useful tool for diagnosis, prognosis, and biomarker discovery. In this study, an ARMS-HRMA method was developed for detecting KRAS mutations, showing simplicity, shorter time to result, high sensitivity, and specificity compared to traditional sequencing and digital PCR methods. The proposed ARMS-HRMA method has the potential to improve liquid biopsy-based diagnosis and prognosis schemes.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Ana F. Amendoeira, Andre Luz, Ruben Valente, Catarina Roma-Rodrigues, Hasrat Ali, Johan E. van Lier, Fernanda Marques, Pedro V. Baptista, Alexandra R. Fernandes
Summary: This study evaluated the cell uptake of Estradiol-BODIPY, 19-nortestosterone-BODIPY, and testosterone-BODIPY in breast cancer and prostate cancer cells, as well as in normal dermal fibroblasts. The results showed that the highest internalization occurred in cells expressing specific receptors for the compounds. Blocking experiments also revealed differences in non-specific cell uptake between cancer and normal cells, possibly due to differences in lipophilicity. The internalization process was energy-dependent and mediated by clathrin- and caveolae-endocytosis. Co-culture studies demonstrated that the compounds exhibited selectivity towards cancer cells. Furthermore, the compounds showed non-toxicity towards cancer and/or normal cells, and visible light irradiation induced cell death, indicating their potential use as PDT agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Katarzyna Choroba, Beatriz Filipe, Anna Switlicka, Mateusz Penkala, Barbara Machura, Alina Bienko, Sandra Cordeiro, Pedro V. Baptista, Alexandra R. Fernandes
Summary: The study focused on the anticancer properties of dipicolinate-basedvanadium(IV) complexes with different diimines. These complexes showed high cytotoxic effect against HCT116-DoxR cells and induced cell death through apoptosis and autophagy pathways. They also interacted with BSA protein and did not promote tumor cell migration or angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Beatriz J. Coelho, Joana P. Neto, Barbara Sieira, Andre T. Moura, Elvira Fortunato, Rodrigo Martins, Pedro V. Baptista, Rui Igreja, Hugo Aguas
Summary: Microfluidic-based platforms are powerful tools for chemical and biological assays. The fusion of different microfluidic technologies has the potential to overcome limitations and enhance their strengths.
Article
Polymer Science
Beatriz J. Coelho, Joana V. Pinto, Jorge Martins, Ana Rovisco, Pedro Barquinha, Elvira Fortunato, Pedro V. Baptista, Rodrigo Martins, Rui Igreja
Summary: Poly(p-xylylene) derivatives, also known as Parylenes, have been extensively studied for their thermal, structural, and electrical properties. This article explores the application of Parylene C in various electronic devices, including transistors, capacitors, and digital microfluidic devices. The results show that Parylene C can be used as a dielectric, substrate, and encapsulation layer in transistors, producing high performance devices with steep transfer curves, low gate leak currents, and good mobilities. The study also demonstrates the functionality of Parylene C in MIM structures and its capability to enable faster droplet motion and nucleic acid amplification reactions in DMF devices.
Article
Pharmacology & Pharmacy
Catarina Roma-Rodrigues, Alexandra R. Fernandes, Pedro V. Baptista
Summary: Neoangiogenesis is associated with poor prognosis in cancer, including chronic myeloid leukemia (CML). The small GTP-binding protein Rab11a plays a crucial role in the neoangiogenic process in CML patients, by controlling exosome secretion and regulating vascular endothelial factor receptors. By downregulating Rab11a mRNA in CML cells, the angiogenic potential of exosomes can be reduced, offering a potential therapeutic approach for inhibiting tumor angiogenesis.
Review
Biochemistry & Molecular Biology
Oscar A. Lenis Rojas, Sandra Cordeiro, Pedro V. Baptista, Alexandra R. Fernandes
Summary: The ruthenium arene fragment is a valuable source for designing anticancer drugs, and the co-ligand plays a crucial role in obtaining effective anticancer complexes. N-heterocyclic carbenes (NHCs), despite their versatility and ability to stabilize metal ions, have not been extensively explored. However, recent advancements have been made in the development of NHC ruthenium arene complexes as potent anticancer agents.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Review
Engineering, Electrical & Electronic
Maria Elias Pereira, Rodrigo Martins, Elvira Fortunato, Pedro Barquinha, Asal Kiazadeh
Summary: Neuromorphic computing is gaining popularity as a replacement for outdated technology in conventional computing systems. Artificial neural networks composed of memristor crossbars in hardware offer power, cost, and area-efficient in-memory computing and storage. Optoelectronic memristors (OEMs) can control resistive switching (RS) through both optical and electronic signals, solving crosstalk issues and providing a high-speed non-destructive method. This review summarizes recent advances in inorganic OEMs, analyzing the device structure and assessing their potential applications in logic gates, artificial neural networks, and artificial visual systems with consideration for their performance.
NEUROMORPHIC COMPUTING AND ENGINEERING
(2023)
Article
Chemistry, Analytical
Maria Joao Oliveira, Soraia Caetano, Ana Dalot, Filipe Sabino, Tomas R. Calmeiro, Elvira Fortunato, Rodrigo Martins, Eulalia Pereira, Miguel Prudencio, Hugh J. Byrne, Ricardo Franco, Hugo Aguas
Summary: Early and accurate detection of pathogenic microorganisms is crucial for diagnosis and patient outcomes. The combination of a polystyrene-based microfluidic device and Surface-Enhanced Raman Spectroscopy shows excellent sensitivity and specificity in detecting malaria. The system can be easily adapted for other pathogens and has the potential for early diagnosis of infectious diseases.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
