Article
Computer Science, Information Systems
Anastasia Bulgakova, Anton Berdyugin, Olga Naumova, Boris Fomin, Dmitrii Pyshnyi, Alexey Chubarov, Elena Dmitrienko, Alexander Lomzov
Summary: Nanowire or nanobelt sensors based on silicon-on-insulator field-effect transistors (SOI-FETs) are a leading direction for label-free biosensors. Reproducible results from electrochemical measurements are important for this device construction type, and are affected by factors including the measuring solution and sensor design parameters. The pH value should be chosen to minimize surface charge for maximum sensitivity and effect from charged molecule interactions. The study found that 3 μm wide nanobelt sensing elements are most suitable for reliable analysis of biomolecules at pH values over 7.
Article
Biochemistry & Molecular Biology
Melanie Welden, Arshak Poghossian, Farnoosh Vahidpour, Tim Wendlandt, Michael Keusgen, Christina Wege, Michael J. Schoening
Summary: This study presents a new approach for developing field-effect biosensors using an electrolyte-insulator-semiconductor capacitor (EISCAP) modified with a stacked bilayer of weak polyelectrolyte and tobacco mosaic virus (TMV) particles as enzyme nanocarriers. The TMV particles were loaded onto the EISCAP surface modified with a positively charged poly(allylamine hydrochloride) (PAH) layer to increase the surface density and achieve dense immobilization of enzymes. The PAH/TMV bilayer-modified EISCAP biosensor, with immobilized penicillinase enzyme, exhibited high sensitivity in detecting penicillin concentrations.
BIOELECTROCHEMISTRY
(2023)
Article
Optics
Wen-Qi Wei, An He, Bo Yang, Zi-Hao Wang, Jing-Zhi Huang, Dong Han, Ming Ming, Xuhan Guo, Yikai Su, Jian-Jun Zhang, Ting Wang
Summary: This article introduces an embedded InAs/GaAs quantum dot (QD) laser directly grown on a SOI substrate, enabling monolithic integration with silicon waveguides. By resolving the epitaxy and fabrication challenges, embedded III-V lasers on SOI with continuous-wave lasing are obtained, providing a scalable and low-cost epitaxial method for future high-density photonic integration.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Article
Optics
Jing-Zhi Huang, Wen-Qi Wei, Jia-Jian Chen, Zi-Hao Wang, Ting Wang, Jian-Jun Zhang
Summary: This study achieved the monolithic integration of a stable III-V laser on a standard silicon-on-insulator substrate, proposed a double-side heat dissipation design, successfully demonstrated room-temperature operation of InAs/GaAs QD lasers, and showed the effectiveness of top heat sink design through thermal profile simulation.
Article
Optics
Junhu Zhou, Jie You, Hao Ouyang, Runlin Miao, Xiang'ai Cheng, Tian Jiang
Summary: This study presents a theoretical analysis of a novel multi-channel light amplification photonic system on chip, utilizing the nonlinear Raman amplification phenomenon in silicon wire waveguides and a temperature insensitive Mach-Zehnder interferometer filter as demultiplexer. The system incorporates various optical effects to achieve thermal robustness and prevent thermal interference, showing promising potential for future applications.
CHINESE OPTICS LETTERS
(2022)
Article
Chemistry, Analytical
Zebin Xu, Jiahui Yan, Meilin Ji, Yongxin Zhou, Dandan Wang, Yuanzhi Wang, Zhihong Mai, Xuefeng Zhao, Tianxiang Nan, Guozhong Xing, Songsong Zhang
Summary: This paper presents a piezoresistive differential pressure sensor based on a silicon-on-insulator (SOI) structure for low-pressure detection. By optimizing the process, the sensor achieves a controllable thickness of the pressure-sensing diaphragm and ensures good ohmic contact. The experimental results show that the sensor has high sensitivity, temperature stability, and is suitable for high-temperature and miniaturized low-pressure sensor research.
Article
Engineering, Electrical & Electronic
Liqiao Liu, Xu Ren, Kai Zhao, Yandong He, Gang Du
Summary: This article presents a frame differencing pixel (FDP) design using fully depleted silicon-on-insulator (FD-SOI) technology. The FDP demonstrates the capability to perform real-time frame difference (FD) at the pixel level for motion extraction and image preprocessing. TCAD simulations were conducted to analyze the FD-SOI FDP, and an optimal pixel design model was developed to explain the relationship between noise performance and area allocation. Simulation results show that the FDP can achieve a light sensitivity of 25.6 mu A/(mu J/cm(2)) and a differential signal-to-noise ratio of 35 dB with specific pixel parameters.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2023)
Article
Chemistry, Physical
Zicheng Lu, Hong Zhou, Yi Wang, Yanxiang Liu, Tie Li
Summary: Silicon nanowire field-effect transistor (SiNW-FET) sensors have the capability of rapid, real-time, and label-free detection of charged molecules with high sensitivity and selectivity. By a combination of horizontal and vertical control, a novel fabrication approach for silicon nanowires has been developed, resulting in improved device uniformity and lower current fluctuation. The new approach shows a more accurate bio-analysis application of the silicon nanowire sensor.
Article
Engineering, Electrical & Electronic
Kouichi Hagino, Masatoshi Kitajima, Takayoshi Kohmura, Ikuo Kurachi, Takeshi G. Tsuru, Masataka Yukumoto, Ayaki Takeda, Koji Mori, Yusuke Nishioka, Takaaki Tanaka
Summary: This article reports the degradation mechanism of XRPIX due to radiation using device simulations. Mechanisms of increases in dark current and readout noise are investigated, taking into account the positive charge accumulation in the oxide layer and the increase in the surface recombination velocity at the interface. It is found that the depletion of the buried p-well (BPW) increases the dark current and the increase in the sense-node capacitance increases the readout noise.
IEEE TRANSACTIONS ON NUCLEAR SCIENCE
(2023)
Article
Engineering, Electrical & Electronic
Matthias L. Vermeer, Raymond J. E. Hueting, Luca Pirro, Jan Hoentschel, Jurriaan Schmitz
Summary: Quantification of interface traps in double-gate fully depleted silicon-on-insulator transistors is crucial for accurate device modeling and technology development. A new method combining the g(m)/I-D method and a revised form of the k-sweep method was developed in this study, resulting in a typical trap density of 2*10^(11)cm^(-2)eV^(-1). However, the allocation of traps to the front or back interface is challenging, with at least a 20% error reported.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2021)
Article
Engineering, Electrical & Electronic
Marina Antoniou, Florin Udrea, Elizabeth Kho Ching Tee, Alex Hoelke
Summary: PSOI technology is a suitable choice for high-voltage integrated circuits, offering a wider range of voltage ratings, lower on-state resistance, and better heat conduction. In this study, a PSOI technology platform is introduced, which can achieve voltage ratings ranging from 45 to 400V, while providing low on-state resistance, good hot carrier injection stability, and electrostatic discharge capability for high-voltage devices.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Chemistry, Physical
Soumya Kumari, Saurabh Mani Tripathi
Summary: This study focuses on the simulation and optimization of SOI hybrid plasmonic waveguides for enhanced sensitivity in bulk and affinity sensing applications. By considering the example of beta-Lactoglobulin protein molecules, the performance of the sensors has been investigated. It has been observed that a high refractive index sensitivity and figure of merit can be achieved when 10% beta-Lactoglobulin molecules are present in the sample. Furthermore, the influence of the thickness of biomolecule adlayer on the sensitivity has been studied, and a more practical approach for affinity sensing has been proposed.
Article
Physics, Applied
Yucheng Chen, Peng Zhang, Yuxia Li, Kun Zhang, Jinpeng Su, Liangsong Huang
Summary: A flexible capacitive pressure sensor based on micro-structured electrode has been developed, showing high sensitivity and good stability, suitable for applications in healthcare and smart services. By optimizing the size of the electrode microstructure, the sensor can achieve a sensitivity of 1.3 kPa(-1) in different pressure ranges. Assembled in arrays, the sensor can be used to monitor arterial pulse waves and breathing, proving its applicability in complex scenarios.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Engineering, Electrical & Electronic
Benito Gonzalez, Jose M. Cabrera, Antonio Lazaro
Summary: Thermal impedance is essential for describing the thermal behavior in SOI devices. An empirical physical model based on gate length was proposed in this study to calculate the thermal impedance of multi-finger PD SOI MOSFETs. The parameters of the model were obtained from measurements, and it correctly predicted the thermal time constants for various gate lengths.
IEEE TRANSACTIONS ON ELECTRON DEVICES
(2022)
Article
Chemistry, Physical
Yexin Chen, Qinghai Zhu, Xiaodong Zhu, Yijun Sun, Zhiyuan Cheng, Jing Xu, Mingsheng Xu
Summary: In this study, a gate-tunable, high-performance, self-driving, and wide detection range phototransistor based on a 2D PtSe2 on silicon-on-insulator (SOI) was proposed. The phototransistor showed fast response time and excellent photodetection performance over a broad spectral range from ultraviolet to near-infrared.
Article
Materials Science, Multidisciplinary
Denise Molinnus, Heiko Iken, Anna Lynn Johnen, Benjamin Richstein, Lena Hellmich, Arshak Poghossian, Joachim Knoch, Michael J. Schoening
Summary: Miniaturized electrolyte-insulator-semiconductor capacitors with ultrathin gate insulators were studied for their pH-sensitive sensor characteristics. Different combinations of gate insulator layer structures were characterized and it was found that SiO2-Ta2O5 stack showed the best overall sensor characteristics, while Si3N4-Ta2O5 stack had the highest accumulation capacitance and steepest slope in the capacitance-voltage curve among the studied systems.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2022)
Article
Chemistry, Analytical
Melanie Welden, Arshak Poghossian, Farnoosh Vahidpour, Tim Wendlandt, Michael Keusgen, Christina Wege, Michael J. Schoening
Summary: Utilizing tobacco mosaic virus particles as nanoscaffolds, a bi-enzyme EISCAP biosensor was developed for sequential detection of penicillin and urea. The biosensor exhibited high sensitivity and precision, and could also mimic an enzyme logic gate.
Article
Engineering, Biomedical
Jiri Ehlich, Ludovico Migliaccio, Ihor Sahalianov, Marta Nikic, Jan Brodsky, Imrich Gablech, Xuan Thang Vu, Sven Ingebrandt, Eric Daniel Glowacki
Summary: The study evaluated oxygen reduction reactions (ORR) at different electrode materials and found significant differences in onset potentials and H2O2 production between materials. It concluded that typical charge-balanced biphasic pulse protocols can lead to irreversible ORR, inducing hypoxic conditions and accumulation of hydrogen peroxide near the electrode surface. These findings emphasize the importance of considering faradaic ORR in neural interface devices and highlight potential physiological consequences of hypoxia and H2O2.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Engineering, Biomedical
Andrea Kauth, Anne-Kathrin Mildner, Lena Hegel, Joachim Wegener, Sven Ingebrandt
Summary: When cells or tissues are exposed to a pulsed electric field, the cellular membrane permeabilizes, allowing gene electrotransfer (GET) to occur. GET using micro-/nano technology offers higher spatial resolution and lower voltage amplitudes compared to conventional bulk electropermeabilization (EP). In this study, we developed a specialized microelectrode array (MEA) for localized EP of adherent cells, demonstrating its functionality through loading of a fluorophore dye and subsequent expression of green fluorescent protein.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Kevin A. Janus, Stefan Achtsnicht, Laura Tempel, Aleksander Drinic, Alexander Kopp, Michael Keusgen, Michael J. Schoening
Summary: In this study, fibroin, polylactide (PLA), and carbon were investigated as biocompatible and biodegradable materials for amperometric biosensors. The carbon electrodes on fibroin and PLA substrates were modified with a glucose oxidase membrane and then encapsulated with the biocompatible material Ecoflex. Different curing parameters of the carbon electrodes were studied to determine their effect on the biosensor characteristics. The morphology of the electrodes was examined using scanning electron microscopy, and the biosensor performance was measured through amperometric measurements of glucose in a phosphate buffer solution.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Materials Science, Multidisciplinary
Felix Jiang, Guangzhen Xie, Jochen Heiss, Zhongkai Zhang, Sven Ingebrandt, Xuan Thang Vu
Summary: In this study, the electrical resistivity, Seebeck coefficient, and power factor of an indium tin oxide (ITO) and nickel-chromium (NiCr) thermocouple were investigated. The thicknesses of ITO and NiCr were varied from 10 to 430 nm. The measured Seebeck coefficients were between 12.8 and (21.4 +/- 1.5) mu V K-1, respectively. The results showed that a reduction in thickness generally led to an increase in the Seebeck coefficient until a maximum value was reached. Among the measured samples, the optimal Seebeck coefficients were found with an ITO thickness of (111 +/- 4) nm and NiCr thickness of (18 +/- 2) nm. Finally, the power factor of the thermocouples was determined, with a maximum power factor of (84 +/- 7) mu W m(-1 )K(-2) for the ITO thickness of (111 +/- 4) nm and nickel-chromium thickness of (42 +/- 5) nm.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Mechanics
Marcel Tintelott, Pradnya Gharpure, Yannick Coffinier, Xuan Thang Vu, Alexis Vlandas, Sven Ingebrandt, Vivek Pachauri
Summary: In this study, a chip platform combining biochemical reaction networks (BRNs) with nanoscale biologically sensitive field-effect transistor (BioFET) arrays was designed, which achieved spatial and temporal control over mass transport through a physical diffusion barrier. Computational and numerical methods were used to solve partial differential equations numerically for precise control over mass transport. By monitoring BRNs with a limit of detection (LoD) of 0.5 pM via a single-stranded deoxyribonucleic acid (ssDNA) output, it was demonstrated that compartmentalized mass transport could be achieved without crosstalk, which could be advantageous for simplified multiplexed point-of-care biosensors.
Article
Materials Science, Multidisciplinary
Tobias Karschuck, Stefan Schmidt, Stefan Achtsnicht, Arshak Poghossian, Patrick Wagner, Michael Josef Schoening
Summary: Compared to single-analyte devices, multiplexed systems for multianalyte detection offer advantages such as reduced assay time and sample volume, low cost, and high throughput. In this study, a multiplexing platform was developed for the automated simultaneous characterization of multiple capacitive field-effect sensors using the capacitive-voltage (C-V) and constant-capacitance (ConCap) mode. The platform consists of a multicell arrangement with a common reference electrode, where the sensors are electrically connected to an impedance analyzer via a base station. The system was tested for pH measurements and the label-free detection of ligand-stabilized, charged gold nanoparticles, showing promising results.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Instruments & Instrumentation
Felix Jiang, Meguya Ryu, Vivek Pachauri, Sven Ingebrandt, Xuan Thang Vu, Junko Morikawa
Summary: A device for measuring the thermal diffusivity of SiNx membranes was developed, and the phenomenon was detected using the photothermal method and contact detection of temperature response at different frequency ranges. The measured thermal diffusivity values were smaller than those of bulk material, likely due to the confined state of phonons in the membrane's nanoscale geometry.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2023)
Article
Virology
Tim Wendlandt, Claudia Koch, Beate Britz, Anke Liedek, Nora Schmidt, Stefan Werner, Yuri Gleba, Farnoosh Vahidpour, Melanie Welden, Arshak Poghossian, Michael J. Schoening, Fabian J. Eber, Holger Jeske, Christina Wege
Summary: Immunosorbent turnip vein clearing virus (TVCV) particles displaying the IgG-binding domains of Staphylococcus aureus protein A (PA) were purified from plants. These particles could be loaded with antibodies and used for the immobilization of various substances. The TVCVPA carriers showed increased reusability compared to traditional methods, and the virus could be used for durable TVCVPA-assisted electrochemical biosensing.
Article
Chemistry, Multidisciplinary
Ruifeng Zhu, Gabriela Figueroa-Miranda, Lei Zhou, Ziheng Hu, Bohdan Lenyk, Sven Ingebrandt, Andreas Offenhaeusser, Dirk Mayer
Summary: A dual-signal protocol was developed, combining electrochemical and optical detection methods using gold nanopit arrays, to improve aptamer-based biosensors. The non-fully penetrating AuNpA showed better plasmonic properties and enlarged the electrochemical active surface area compared to fully penetrating structures. The simultaneous use of electrochemical and optical transducers led to different detection limits, dynamic ranges, and sensitivities, providing new opportunities for disease diagnosis and point-of-care testing.
Article
Chemistry, Analytical
Paulo V. Morais, Pedro H. Suman, Michael J. Schoening, Jose R. Siqueira Jr, Marcelo O. Orlandi
Summary: This study aims to fabricate a reusable and robust sensing unit on an electrolyte-insulator-semiconductor (EIS) device to detect heavy metal ions such as lead and nickel. The EIS-Sn3O4 sensor shows a higher affinity for Pb2+ ions with a sensitivity of approximately 25.8 mV/decade, suggesting its potential as a feasible capacitive field-effect sensor for heavy metal detection.
Article
Chemistry, Analytical
Morten Bertz, Denise Molinnus, Michael J. Schoening, Takayuki Homma
Summary: Hydrogen peroxide (H2O2) is widely used as a sterilization agent in aseptic food processing and medical applications. Little is known about the detailed mechanism of oxidative spore death by H2O2. This study investigates the chemical and morphological changes of Bacillus atrophaeus spores undergoing oxidative damage, revealing two distinct phases of spore death and the role of reactive oxygen species in the process.
Article
Biotechnology & Applied Microbiology
Dua Oezsoylu, Kevin A. Janus, Stefan Achtsnicht, Torsten Wagner, Michael Keusgen, Michael J. Schoening
Summary: Skin grafting is a common surgical procedure in dermatology, but failure rates are still high, causing significant burden. Real-time and objective monitoring of grafts is essential for evidence-based treatment. Advanced sensor applications using nanotechnology and material science can provide this monitoring.
SENSORS AND ACTUATORS REPORTS
(2023)
Article
Biophysics
Milad Eyvazi Hesar, Niloofar Sadat Seyedsadrkhani, Dibyendu Khan, Adib Naghashian, Mateusz Piekarski, Henning Gall, Ralph Schermuly, Hossein Ardeschir Ghofrani, Sven Ingebrandt
Summary: This research presents a wearable epidermal electronic system for continuous monitoring of a prognostic parameter for hypertension. The system is flexible, wireless, and smartphone-enabled, allowing real-time monitoring of electrocardiograms and seismocardiograms. The system shows promising performance in predicting hypertension.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
