Article
Polymer Science
Jorge-A. Ortega-Contreras, Edgar Alvarado-Mendez, Guillermo Almanza-Rodriguez, Maria del Carmen Hernandez, Luis Celaya-Garcia
Summary: In this study, a biocatalytic glucose optical sensor was developed by immobilizing glucose oxidase (GOD) on a polymethylmethacrylate (PMMA) optical fiber. The enzyme encapsulation process was carried out using the sol-gel method, with a TEOS-based coating deposited on the fiber end by immersion. The sensor was characterized using different glucose levels. The optimal enzyme encapsulation process was found to be performed at room temperature, followed by the deposition of the coating on the fiber. The drying process showed optimal results at temperatures below 8°C.
Article
Medicine, Research & Experimental
Ifra Sanaullah, M. Imran, Saira Riaz, Tabassum Amin, Irfan Ullah Khan, Rizwana Zahoor, Abubaker Shahid, Shahzad Naseem
Summary: Fe3O4-stabilized zirconia nanoparticles were successfully synthesized using microwave-assisted sol-gel method, showing great potential for diagnostic and therapeutic applications with good in vivo biodistribution.
Article
Chemistry, Analytical
Hamzeh Khani, Shahryar Abbasi, Mohammad Tavakkoli Yaraki, Mohammad Bagher Gholivand
Summary: A simple design for a naked-eye colorimetric biosensor for rapid and ultrasensitive detection of GSH in human serum was reported. The biosensor showed a limit of detection of 34 nM and excellent selectivity towards interference substances, making it suitable for practical detection and determination of GSH levels in real samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Environmental Sciences
Krishna Kanthi Gudimella, Gangaraju Gedda, P. Senthil Kumar, B. K. Babu, Bhaskar Yamajala, Battula Venkateswara Rao, Prabal Pratap Singh, Deepak Kumar, Ajit Sharma
Summary: Fluorescent carbon dots were prepared from Carica Papaya Leaves using the sand bath method and characterized for various properties. The CDs exhibited excellent biological activities in biomedical applications, suggesting their potential as therapeutic agents.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Klaudia Jomova, Marcel Cvik, Peter Lauro, Marian Valko, Erik Cizmar, Suliman Y. Alomar, Saleh H. Alwasel, Patrik Oleksak, Zofia Chrienova, Eugenie Nepovimova, Kamil Kuca, Christopher J. Rhodes
Summary: The antioxidant properties of flavonoids with hydroxyl groups allow them to chelate redox active metals and scavenge free radicals. This paper studies the antioxidant and prooxidant properties of baicalein and its complexes with Cu(II) under different conditions. The results show that baicalein and Cu(II)-baicalein complexes have moderate ROS scavenging efficiency and can protect DNA from damage caused by ROS. These findings suggest that baicalein could be a therapeutic agent for diseases involving disrupted metabolism of copper, while low concentrations of baicalein may not inhibit the pro-oxidant effect of copper ions and ascorbate in cancer cells, leading to effective DNA damage.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Quan V Vo, Nguyen Thi Hoa, Nguyen Minh Thong, Adam Mechler
Summary: The study found that anthocyanidins have high HOO· scavenging activity in water but weak activity in lipid medium. In water at pH = 7.4, the anion states and single electron transfer mechanism play a dominant role in the scavenging activity of anthocyanidins.
Article
Spectroscopy
Herbert Cirrus Kaboggoza, Burcu Bekdeser, Resat Apak
Summary: A fluorescent gold nanocluster was used to determine the peroxyl radical scavenging activity of antioxidants. The addition of glutathione enhanced the fluorescence intensity of the gold nanoclusters, while antioxidants reduced the decline in fluorescence intensity caused by peroxyl radical attack. This method provides a simple and selective estimation of peroxyl radical scavenging activity in complex matrices.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Materials Science, Multidisciplinary
Citlali Alejandra Marin-Flores, Odin Rodriguez-Nava, Margarita Garcia-Hernandez, Rosario Ruiz-Guerrero, Fernando Juarez-Lopez, Angel de Jesus Morales-Ramirez
Summary: ZnO particles were synthesized and their free radical scavenging activity properties were evaluated in this study. The results showed that the scavenging activity increased with smaller particle size and lower ZnO dosage. A pseudo-first-order kinetics model may be present in the reaction.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Materials Science, Ceramics
Hiroyuki Hayashi, Keita Kouzai, Yuta Morimitsu, Isao Tanaka
Summary: Despite extensive research, accurately predicting successful synthesis conditions for new pseudo-binary oxides remains a challenge. This study introduces a synthesis-condition recommender system to efficiently explore a wide chemistry space and successfully discovered two yet-to-be-found pseudo-binary oxides through systematic synthesis experiments.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Multidisciplinary
Leandro L. Peres, Camila M. Cholant, Rafaela M. J. Lemos, Marco P. Rodrigues, Luana U. Krueger, Richard Pereira, Wladimir H. Flores, Andre Guendel, Douglas L. da Silva, Agnieszka Pawlicka, Cesar O. Avellaneda
Summary: This study used the peroxovanadate sol-gel method to produce ZnO-doped V2O5 thin films and investigated the effect of doping on the electrochromic and structural characteristics of the films. The results showed that ZnO doping improved the cyclic stability and reversibility of the films, making them promising candidates for electrochromic device applications.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Materials Science, Multidisciplinary
Leandro L. Peres, Camila M. Cholant, Rafaela M. J. Lemos, Marco P. Rodrigues, Luana U. Kruger, Richard Pereira, Wladimir H. Flores, Andre Gundel, Douglas L. da Silva, Agnieszka Pawlicka, Cesar O. Avellaneda
Summary: The study used the peroxovanadate sol-gel method to produce ZnO-doped V2O5 thin films, demonstrating that ZnO doping improved the cyclic stability and reversibility of the films and resulted in a mixture of crystalline phases.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Marko R. Antonijevic, Edina H. Avdovic, Dusica M. Simijonovic, Ziko B. Milanovic, Ana D. Amic, Zoran S. Markovic
Summary: This paper investigated the antioxidative properties and radical scavenging abilities of five different coumarin derivatives. The results showed that these compounds have good antioxidative potential and radical scavenging abilities, and they meet the criteria of drug-likeness tests. In addition, three additional mechanisms of radical scavenging activity were discovered.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
Ivana Novak Jovanovic, Robert Vianello, Dijana Jadresko, Livio Racane, Marijana Hranjec
Summary: This study reports on the electrochemical properties and antioxidant activity of four 2-hydroxy/methoxy-phenylbenzothiazole derivatives. The results show that two derivatives have the main electroactive center at the C6-amino group of the benzothiazole molecule, while the other two derivatives have the main electroactive center at the pyrogallol group.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Sergei O. Liubimovskii, Leila Yu Ustynyuk, Alexander N. Tikhonov
Summary: Tiron is commonly used as a probe for detection of superoxide radicals. The interaction of Tiron with superoxide radicals dissolved in water solutions was studied using density functional theory (DFT) method. The reactions of Tiron with superoxide radicals are influenced by hydronium ions, leading to the formation of Tiron semiquinone radicals.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Physical
Aylin M. Deliormanli, Begum Rahman
Summary: Superparamagnetic-fluorescent bioactive glasses were fabricated by incorporating maghemite nanoparticles and rare earth element ions into bioactive glasses. The morphological, structural, magnetic, and luminescence properties of the glasses were investigated using different techniques. Results showed that all the glasses had superparamagnetic properties and fluorescence behavior, with the fibrous glass samples showing the highest hydroxyapatite formation rates due to their larger surface area.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Chemistry, Multidisciplinary
Amalia Garcia-Garcia, Sara Rojas, Lorenzo Rivas-Garcia, Maria D. Navarro-Hortal, Jose M. Romero-Marquez, Jose G. Fernandez-Bolanos, Duane Choquesillo-Lazarte, Alfonso Salinas-Castillo, Oscar Lopez, Jose L. Quiles, Antonio Rodriguez-Dieguez
Summary: A new palladium coordination compound based on gliclazide has been synthesized and characterized, showing promising inhibitory activity against an enzyme related to Alzheimer's disease and protective activity in a Caenorhabditis elegans model.
CHEMICAL COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Biresaw D. Abera, Inmaculada Ortiz-Gomez, Bajramshahe Shkodra, Francisco J. Romero, Giuseppe Cantarella, Luisa Petti, Alfonso Salinas-Castillo, Paolo Lugli, Almudena Rivadeneyra
Summary: A sensitive and label-free sensor was developed for the detection of tetracycline residue in animal-origin food products. The sensor used CO2 laser-induced graphene electrodes modified with gold nanoparticles and a molecularly imprinted polymer as a synthetic biorecognition element. The sensor showed good sensitivity and stability, and can be used as an alternative system for the detection of tetracycline.
Article
Chemistry, Analytical
Amalia Garcia-Garcia, Victor Toral, Jose F. Quilez del Moral, Alberto Galisteo Pretel, Diego P. Morales, Alfonso Salinas-Castillo, Javier Cepeda, Duane Choquesillo-Lazarte, Marco Bobinger, Jose F. Salmeron, Almudena Rivadeneyra, Antonio Rodriguez-Dieguez
Summary: In this study, a novel coordination polymer (CP) based on perylene-3,4,9,10-tetracarboxylate (pery) linkers and sodium metal ions was synthesized. By modifying the properties of the metal ions, we confirmed their role in the functionalization of the material and paved the way for the generation of sensitive and selective chemical sensors.
Article
Chemistry, Multidisciplinary
Inmaculada Ortiz-Gomez, Sergio Gonzalez-Alfaro, Antonio Sanchez-Ruiz, Ignacio De Orbe-Paya, Luis Fermin Capitan-Vallvey, Amparo Navarro, Alfonso Salinas-Castillo, Joaquin C. Garcia-Martinez
Summary: A new approach utilizing aggregation induced emission (AIE) properties for the development of fluoride chemosensors was proposed in this study. By combining ACQ and AIE properties between fluorescent molecules, a turn-off chemosensor in solution can be transformed into turn-on in the solid state. The developed device showed high sensitivity and reliable detection capabilities using a microfluidic paper-based analytical system.
Review
Chemistry, Medicinal
Alberto Falco, Mikolaj Adamek, Patricia Pereiro, David Hoole, Jose Antonio Encinar, Beatriz Novoa, Ricardo Mallavia
Summary: This review discusses the high proliferation of microorganisms in aquatic environments and their coevolution with other organisms. The study highlights the potential of the broad biodiversity in marine habitats for the discovery and development of antimicrobial compounds. Antimicrobial peptides and antimicrobial metabolites are of particular interest due to their structural diversity, mechanisms of action, and target pathogen ranges.
Article
Chemistry, Analytical
Javier Cepeda, Isabel Blasco-Pascual, Sara Rojas, Duane Choquesillo-Lazarte, Francisco J. Guerrero-Arroyo, Diego P. Morales, Jose Angel Garcia, Antonio Rodriguez-Dieguez, Alfonso Salinas-Castillo
Summary: Two novel metal-organic frameworks (MOFs) based on dysprosium as the metal and the 5-aminoisophthalic acid (5aip) ligand have been synthesized. By modulating the solvent, the luminescence properties of these materials can be studied and controlled. The materials exhibit strong photo-luminescence properties at room temperature. Especially, compound 2 shows fascinating sensory capacity by varying the signal depending on the solvent, suggesting potential applications in sensitive chemical sensors.
Article
Biochemistry & Molecular Biology
Rocio Esquembre, Maria Lourdes Renart, Jose Antonio Poveda, C. Reyes Mateo
Summary: The nanostructuration of solid matrices with lipid nanoparticles containing membrane proteins is a promising tool for the development of high-throughput screening devices. The results indicate that this device has the potential to be used as a screening platform for potassium channel drugs.
Article
Biochemistry & Molecular Biology
Yolanda Alacid, Maria Jose Martinez-Tome, Rocio Esquembre, M. Antonia Herrero, C. Reyes Mateo
Summary: In this study, alkaline phosphatase (ALP) was incorporated into a three-dimensional polymeric network through a green protocol to obtain transparent hydrogels (ALP@AETA). The immobilized enzyme retained its activity, slightly increased its thermal stability, and could be stored as a xerogel at room temperature. The ALP@AETA xerogel showed promise as a disposable biosensor for detecting ALP inhibitors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Marta Rubio-Camacho, Maria Jose Martinez-Tome, Carlos Cuestas-Ayllon, Jesus M. de la Fuente, Rocio Esquembre, C. Reyes Mateo
Summary: A fast and environmentally-friendly method has been developed for the synthesis of gold nanoparticles (AuNPs) on thermosensitive liposomes. The arrangement of the AuNPs can be controlled and tuned by the lipid phase, charge, and synthesis temperature. The resulting nanohybrids show plasmon peaks within the visible/near-infrared region and retain the physical properties of the liposomes, making them excellent candidates for light-mediated therapies with controlled drug delivery capacity.
COLLOID AND INTERFACE SCIENCE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Salome Araujo-Abad, Antonio Manresa-Manresa, Enrique Rodriguez-Canas, Maria Fuentes-Baile, Pilar Garcia-Morales, Ricardo Mallavia, Miguel Saceda, Camino de Juan Romero
Summary: Glioblastoma (GBM) is an aggressive cancer of brain origin with fast growth and invasion. Small extracellular vesicles (EVs) derived from GBM cells have been isolated and characterized. Loading these EVs with drugs reduced the total amount needed to trigger an effect on tumor cells. Additionally, GBM-derived EVs showed potential for inducing cell death in pancreatic cancer cells. These findings suggest that GBM-derived EVs could be a promising drug delivery tool for further preclinical studies and GBM treatment development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Rocio Diaz-Puertas, Mikolaj Adamek, Ricardo Mallavia, Alberto Falco
Summary: The antimicrobial molecules found in fish skin mucus, including peptides, proteins, and other metabolites, have been shown to have antimicrobial capacity against bacteria, fungi, and viruses. This review highlights the different methods of mucus extraction and emphasizes the importance of omic techniques in identifying and isolating new antimicrobial compounds. Overall, fish skin mucus is a promising source for the discovery of new antimicrobial agents.
Review
Polymer Science
Rocio Diaz-Puertas, Francisco Javier Alvarez-Martinez, Alberto Falco, Enrique Barrajon-Catalan, Ricardo Mallavia
Summary: Antibiotic-resistant bacteria (ARB) pose a significant global health threat, and researchers are exploring alternative strategies to fight bacterial infections. Phytochemicals found in plants have shown potential as antimicrobial agents, but their use has limitations. Combining nanotechnology and antibacterial phytochemicals can enhance the antibacterial capacity against ARB by improving mechanical, chemical, and biological properties. This review provides an overview of phytochemical-based nanomaterials, focusing on polymeric nanofibers and nanoparticles, and discusses their synthesis and antimicrobial activity. The review emphasizes the potential of phytochemical-based nanomaterials for ARB treatment, but highlights the need for further research to optimize their use in clinical settings.
Article
Chemistry, Multidisciplinary
Rocio Diaz-Puertas, Enrique Rodriguez-Canas, Melissa Bello-Perez, Marta Fernandez-Oliver, Ricardo Mallavia, Alberto Falco
Summary: The incorporation of ceramic-coated silver nanoparticles (AgNPs) into thermoplastic polyurethane (TPU) plates showed significant antiviral activity against Spring viraemia of carp virus (SVCV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Article
Chemistry, Analytical
Inmaculada Ortiz-Gomez, Almudena Rivadeneyra, Jose F. Salmeron, Ignacio de Orbe-Paya, Diego P. Morales, Luis Fermin Capitan-Vallvey, Alfonso Salinas-Castillo
Summary: In this study, a microfluidic paper-based analytical device (mu PAD) with an NFC tag was proposed as a portable, simple and fast colorimetric method for glutathione (GSH) determination. The method took advantage of the oxidizing property of Ag+ on 3,3';,5,5'-tetramethylbenzidine (TMB), which resulted in a blue color fading when GSH was present. By integrating electronic interfaces into the hardware of digital image capture, a smartphone was utilized for the colorimetric determination of GSH. Importantly, this new method exhibited a low detection limit of 1.0 mu M, offering high sensitivity and a simple, fast, portable and low-cost GSH determination within 20 minutes using a colorimetric signal.
Article
Chemistry, Analytical
Yolanda Alacid, Rocio Esquembre, Francisco Montilla, Maria Jose Martinez-Tome, C. Reyes Mateo
Summary: This work presents the development and characterization of fluorescent nanocomposite hydrogels using a green protocol. The hydrogels have high swelling and absorption capacity and are prepared by incorporating polyfluorenes-based nanoparticles into a three-dimensional polymeric network. The hydrogels show good storage stability and homogeneity when using the ex situ method. They have been tested as a sensing platform for the detection of alkaline phosphatase with a quick response time and low LOD, making them promising for quantifying physiological ALP levels and enzyme activity in environmental samples.
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
