Article
Optics
Duc Le, Martin Kogler, Tian-long Guo, Matthieu Roussey, Jussi Hiltunen
Summary: Biological particles, such as viruses, lipid particles, and extra-cellular vesicles, have attracted significant research interest due to their important role in biological processes and potential applications in vaccines, diagnostics, and therapies. This study demonstrates the promise of distance-controlled surface-enhanced Raman spectroscopy (SERS) in extracting essential information from the spatial origin of the signal, which is a crucial parameter in the analysis of these biological particles. By using polystyrene beads as a model, the principle of the method is shown using gold nanospheres as distance-controlled SERS probes through biotin-streptavidin binding.
Article
Multidisciplinary Sciences
Francis Schuknecht, Karol Kolataj, Michael Steinberger, Tim Liedl, Theobald Lohmueller
Summary: The label-free identification of individual proteins from liquid samples by surface-enhanced Raman scattering (SERS) spectroscopy has been achieved using a DNA origami scaffold and gold nanorods, providing sufficient field enhancement for single-protein SERS spectroscopy with sub-second integration times.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Ilaria Fratoddi, Chiara Battocchio, Giovanna Iucci, Daniele Catone, Antonella Cartoni, Alessandra Paladini, Patrick O'Keeffe, Silvia Nappini, Sara Cerra, Iole Venditti
Summary: This paper presents the synthesis of silver nanoparticles (AgNPs) functionalized with fluorescent molecules, specifically xanthene-based dyes, and evaluates their chemical structure and optical properties. Characterization of AgNPs-RITC and AgNPs-FITC was conducted using UV-Vis spectroscopy, dynamic light scattering (DLS), and synchrotron radiation X-ray photoelectron spectroscopy (SR-XPS). The study demonstrated the potential of these AgNPs in biosensing and imaging applications by combining plasmonics and fluorescence.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Electrical & Electronic
Nguyen Duy Thien, Tung Huu Dang, Sai Cong Doanh, Le Quang Thao, Nguyen Quang Hoa, Nguyen Minh Hieu, Nguyen Ngoc Dinh, Le Van Vu
Summary: In this study, a quick and easy method for fabricating active-surface-enhanced Raman scattering (SERS) substrates using gold nanoparticles (Au NPs) and porous silicon nanostructures (Si/Au substrate) is presented. The fabrication process involves depositing Au NPs on Si wafers, etching the porous Si wafer, and coating Au NPs on porous Si to create SERS-active layers. The morphology of the Si/Au substrates in each fabrication process was examined, and the absorption spectrum of the substrates showed a strong absorption band at 480 nm due to the surface plasmon resonance of Au NPs. The use of Si/Au substrates greatly enhanced the Raman intensity of Rhodamine B (RB), and the detection limit for RB was estimated to be 0.5 ppm, indicating the potential applications of SERS spectroscopy in various fields such as food, environment, and pharmaceutics.
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
(2023)
Article
Chemistry, Multidisciplinary
Shiqi Hu, Haiping Jiang, Jianqiang Zhu, Jinqiang Wang, Shunhao Wang, Jianbin Tang, Zhuxian Zhou, Sijin Liu, Youqing Shen
Summary: Research shows that rhodamine B isothiocyanate derivatives (RBITCs) exhibit unique tumor-specific fluorescence, which can be utilized for cancer imaging and early diagnosis.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Ambika Shorny, Fritz Steiner, Helmut Hoerner, Sarah M. Skoff
Summary: Pollution by nanoplastic is a growing concern, but measuring its extent in the environment is currently difficult. This study introduces a detection method using surface-enhanced Raman scattering to image and identify single nanoplastic particles as small as 100 nm. The method allows differentiation between single particles and agglomerates, greatly improving detection speed. This research contributes to the understanding and application of surface-enhanced Raman scattering for nanoplastic detection and presents an important advancement for future sensor development.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
A. M. Al-Syadi, M. Faisal, Farid A. Harraz, Mohammed Jalalah, Mabkhoot Alsaiari
Summary: This study demonstrates the effectiveness of using surface-enhanced Raman scattering (SERS) to detect trace concentrations of potentially harmful imidacloprid pesticide. The fabrication of active and stable porous silicon plated with palladium nanoparticles (PdNPs) SERS substrates through electrochemical anodization and immersion plating routes proved to be rapid and highly effective. The PSi-Pd NPs substrates showed significant enhancement in Raman spectral signals when compared to Si-Pd NPs substrates, making them a promising platform for sensitive detection of various target analytes.
SCIENTIFIC REPORTS
(2021)
Article
Spectroscopy
Zhaleh Ghafary, Rahman Hallaj, Abdollah Salimi, Sudabeh Mafakheri
Summary: A novel, highly sensitive, simple and amplified fluorescence immunosensing strategy was designed for HBsAg detection using a sandwich type probe. The probe utilized MSN-Rh.B as a fluorescent mesoporous capsule and signal amplifier site, and Fe3O4 MNP as a probe collector site.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Optics
Mohammad E. Khosroshahi, Vaughan W. Morison, Roxana Chabok, Yesha Patel, Tiam Mohmedi
Summary: This work describes the observation of multi-wavelengths due to stimulated Raman scattering and plasmon-enhanced fluorescence. The fluorescence signal is amplified by coupling with the localized surface plasmons of AuNP, resulting in increased brightness and quantum yield. The study also demonstrates the potential of F-AuNPs for bioimaging and biosensing applications.
Article
Materials Science, Multidisciplinary
Akihiro Koide, Takuji Nomura, Toshiya Inami
Summary: The study introduces sum rules of X-ray magnetic circularly polarized emission (XMCPE) at L edges for 3d transition metals, which can be used to separately obtain z-component expectation values of spin, orbital, magnetic dipole, and quadrupole terms through combinations of incident and emitted photon helicities. The fundamental difference in sum rules between X-ray magnetic circular dichroism and XMCPE stems from the variety of electron transitions involving core states split by the spin-orbit interaction, causing complicated angular dependence of the spin moment sum rule relation in XMCPE. These findings pave the way for future L-edge XMCPE measurements that are currently not observed.
Article
Chemistry, Inorganic & Nuclear
Debdas Singha, Ananya Pal, Partha Roy, Mahasweta Nandi
Summary: A new chemosensor RBA-IMS has been synthesized as a turn-on sensor for selective sensing of Al3+, Cr3+ and Fe3+. The replacement of hydrazine with ethylenediamine has been observed to significantly alter the sensing behavior. The probe does not exhibit any color or fluorescence in the absence of most cations, except for Al3+, Cr3+ and Fe3+. RBA-IMS turns pink when combined with these cations, showing strong absorption and fluorescence signals at specific wavelengths.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Review
Chemistry, Analytical
Nguyen Tran Truc Phuong, Thuy-An Nguyen, Vu Thi Huong, Le Hong Tho, Do Thao Anh, Hanh Kieu Thi Ta, Tran Huu Huy, Kieu The Loan Trinh, Nhu Hoa Thi Tran
Summary: This article reviews the application of SERS sensors for detecting rhodamine in food safety and environmental pollution monitoring, discusses the basic concepts of substrates, enhancement factors, and mechanisms. The trends in substrate development for different applications are mentioned, highlighting the potential application prospects in environmental monitoring.
Article
Chemistry, Analytical
S. N. Aisyiyah Jenie, Yuni Kusumastuti, Fransiska S. H. Krismastuti, Yovilianda M. Untoro, Rizna T. Dewi, Linar Z. Udin, Nina Artanti
Summary: The paper describes the development of fluorescent silica nanoparticles from natural amorphous silica and its application as an Escherichia coli biosensor. The research demonstrates excellent analytical performance and selectivity of the fluorescent silica nanoparticles, with a significant reduction in response time compared to conventional methods.
Article
Optics
Mandana Sadat Hosseini, Elnaz Yazdani, Batool Sajad, Fariba Mehradnia
Summary: The study reveals that the coupling of random lasing and stimulated Raman scattering enables tunable random lasers, offering possibilities for manufacturing optical devices in the future. This coupling effect also aids in enhancing the efficiency and applications of Raman spectroscopy.
JOURNAL OF LUMINESCENCE
(2021)
Article
Chemistry, Physical
Sunny Tiwari, Adarsh B. Vasista, Diptabrata Paul, Shailendra K. Chaubey, G. V. Pavan Kumar
Summary: Experimental observation of beaming elastic and surface enhanced Raman scattering (SERS) emission from a bent-nanowire on a mirror (B-NWoM) cavity. The system utilized a self-assembled monolayer of molecules with a well-defined molecular orientation to achieve beaming SERS emission.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2021)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)