Article
Materials Science, Multidisciplinary
Cheng-Hui Shen, Yu-Na Chang, You-Liang Chen, Chung-Wei Kung
Summary: A highly porous and chemically stable metal-organic framework (MOF) with enriched sulfonate groups, SO3-MOF-808, is synthesized and proposed as a porous alternative to Nafion for modulating the selectivity of electrochemical reactions. The use of SO3-MOF-808 thin film as an electrode coating significantly improves the current signal for dopamine oxidation and the selectivity against interfering compounds.
ACS MATERIALS LETTERS
(2023)
Article
Biochemical Research Methods
Reza Abbasi, Juanjuan Liu, Sorina Suarasan, Sebastian Wachsmann-Hogiu
Summary: Biosensors have great potential in detecting analytes of interest at the point-of-need. Integration of microfluidic and chemiluminescence systems on a single chip allows for simplified sample handling and data collection, making it suitable for applications in medical diagnosis.
Article
Chemistry, Multidisciplinary
Mohamed Choukairi, Dounia Bouchta, Loubna Bounab, Elisa Gonzalez-Romero, Mohamed Achache, Khalid Draoui, Faiza Chaouket, Ihssane Raissouni, Mouad Gharous
Summary: A novel modification of a paste carbon electrode using Bentonite and l-Cysteine was developed for the detection and quantification of uric acid and ascorbic acid. The electrode surface was characterized using electrochemical impedance spectroscopy, scanning electron microscopy, and energy dispersive X-ray spectroscopic analysis. The sensor exhibited good stability, sensitivity, selectivity, and regeneration ability, with a limit of detection of 0.031 μm for uric acid and 9.6 μm for ascorbic acid. The sensor showed good linearity in the concentration range of 0.1-100 μm for uric acid and 10-1000 μm for ascorbic acid. The peak-to-peak separation of uric acid and ascorbic acid was determined to be 330 mV. The sensor was successfully applied for the monitoring of uric acid and ascorbic acid in serum samples.
Article
Materials Science, Multidisciplinary
Emad A. Khudaish, Adhara Al-Badri
Summary: Functionalized carbon nanotubes with excess oxygen-containing functional groups were prepared using a modified Hummers method, showing exceptional electrochemical activity for norepinephrine detection in serum blood samples with a low detection limit. The sensor exhibited good selectivity and recovery rates.
Article
Food Science & Technology
Maria Sabrina Lencina, Cristina dos Santos Ferreira, Diego Archaina, Maria Beatriz Gomez, Maria Florencia Mazzobre
Summary: This study evaluates the effect of adding BCD and AA to FeGlu solution on the iron content and bioaccessibility in vacuum-cooked pumpkin discs. The results show that adding BCD and AA can increase the Fe2+ content in VCPD, improve the solubility and stability of iron, and preserve the color of the pumpkin discs.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Analytical
Ayesha Kousar, Ishan Pande, Laura F. Pascual, Emilia Peltola, Jani Sainio, Tomi Laurila
Summary: One of the major challenges in measuring dopamine (DA) using electro-chemical methods in living organisms is to achieve selectivity in the presence of interfering substances like ascorbic acid (AA) and uric acid (UA). Researchers have used complicated multimaterial structures and ill-defined pretreatments to enhance selectivity. However, the lack of control over the electrode structures has made it difficult to establish a relationship between selectivity and structure. Carbon nanofiber (CNF) electrodes have shown promise in neurobiological applications due to their easily customizable structure. In this study, the sensitivity and selectivity of CNF electrodes towards DA were controlled by adjusting the lengths of the CNF during the fabrication process while maintaining similar surface chemistries. It was found that increasing the fiber length enhanced the sensitivity towards DA while also causing a shift in the oxidation peaks of AA and DA, leading to excellent selectivity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Yonggang Peng, Fan Shao, Kaixi Guo, Hanhan Zhuo, Yuan Wang, Xiaowei Xie, Yongxin Tao
Summary: This study presents a sensitive and selective fluorescence method for the detection of UA and L-Cys using SiQDs/Cu-2-beta-CD nanoclusters. Under strong alkali conditions, UA attenuates the fluorescence of the nanoclusters, while L-Cys has no effect, providing a selective detection method. Under neutral or weak base conditions, L-Cys enhances the fluorescence of the nanoclusters, while UA has no effect, which can also be used for the detection of L-Cys.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Junqiang Pan, Mei Liu, Dandan Li, Haonan Zheng, Dongdong Zhang
Summary: A novel ternary nanocomposite with excellent electro-catalytic activity was successfully prepared for simultaneous detection of dopamine and uric acid under physiological conditions.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Article
Chemistry, Analytical
Eduardo Gaya, Nieves Menendez, Eva Mazario, Pilar Herrasti
Summary: A simple electrochemical sensor based on electrochemically synthesized Fe3O4 nanoparticles was constructed to detect dopamine, uric acid, and ascorbic acid. The sensor showed significant sensitivity and selectivity, without interference from the three analyte molecules presented simultaneously in solution. The sensor has been successfully applied for the detection of these molecules in real samples.
Article
Chemistry, Multidisciplinary
Edwige Mouafo-Tchinda, Justin Claude Kemmegne-Mbouguen, Charles Peguy Nanseu-Njiki, Henrietta W. Langmi, Chrispin Kowenje, Nicholas M. Musyoka, Robert Mokaya
Summary: An organoclay/Cu-MOF composite was synthesized using a solvothermal method and drop coating was used to form a stable thin film onto glassy carbon electrodes. These electrodes demonstrated electrocatalytic behavior toward DXEP, AC, and TYR, enabling their selective and simultaneous sensitive detection compared to bare electrodes and clay modified electrodes.
Article
Chemistry, Analytical
Aqsa Munawar, Farhan Zafar, Saadat Majeed, Masooma Irfan, Hidayat Ullah Khan, Ghazala Yasmin, Naeem Akhtar
Summary: A novel sensing platform based on NC@ZnO was developed for precise monitoring of dopamine. The material was characterized through SEM, TEM, XPS, and Raman spectroscopy, demonstrating the successful application of the enhanced ECL intensity system for dopamine detection.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Article
Electrochemistry
Mohammad A. Hasnat, Munira Siddika, S. M. Nizam Uddin, Khalid A. Alamry, Mohammed M. Rahman
Summary: An efficient electrocatalyst for the direct oxidation of ascorbic acid was developed and implemented on an IrOx immobilized glassy carbon electrode. The GC-IrOx electrode showed excellent oxidation performance and good stability, indicating its potential application as an anode in ascorbic acid fuel cells.
ELECTROCHIMICA ACTA
(2021)
Article
Chemistry, Analytical
Datong Wu, Cong Ma, Fei Pan, Yongxin Tao, Yong Kong
Summary: An electroactive chiral polymer (S,S)-p-CVB-Fc was designed and synthesized to detect nonelectroactive samples using electrochemical techniques. It can be fixed on the surface of a glassy carbon electrode as an electrochemical chiral sensor, showing clear discrimination in the response of peak current towards non-electroactive amino acids such as proline, threonine, and alanine. The current work enlarges the testing scope of chiral samples in the field of chiral electroanalysis using an electroactive sensor.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
M. Shruthi Vishwanath, B. E. Kumara Swamy, K. A. Vishnumurthy
Summary: The mechanochemical method was used to synthesize Zinc oxide nanoparticles (ZnONps) and characterized by EDAX, SEM, and XRD. The oxidative response of L-tryptophan (LTP) was analyzed using a ZnOMCPE and DPV and CV techniques. The modified electrode showed enhanced peak current compared to the BCPE and exhibited good linearity in the concentration range 10-40 mu M (LTP). The polished surface of the modified electrode provided excellent sensitivity, selectivity, and LOD for LTP.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Simin Abedini, Amir Abbas Rafati, Ali Ghaffarinejad
Summary: A low-cost electrochemical sensor based on carbon nanotubes and gold nanoparticles has been developed for the detection of the antiviral drug acyclovir in pharmaceutical preparations. The sensor exhibited excellent sensitivity towards ACV and can be used for routine quantification of drugs in pharmaceutical formulations.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)