Article
Multidisciplinary Sciences
Lei Ying, Luyao Wang, Kaiwen Guo, Yushu Hou, Na Li, Shuyi Wang, Xingfeng Liu, Qijin Zhao, Jie Zhou, Longwei Zhao, Jianlou Niu, Chuchu Chen, Lintao Song, Shaocong Hou, Lijuan Kong, Xiaokun Li, Jun Ren, Pingping Li, Moosa Mohammadi, Zhifeng Huang
Summary: This study identifies paracrine FGF4 as an anti-hyperglycemic FGF that targets skeletal muscle to increase the abundance of the glucose transporter GLUT4 on the cell surface. Compared to endocrine FGF21, the paracrine FGF4 shows superior glycemic control in diabetic mice and has anti-inflammatory properties, suggesting its potential for treating type 2 diabetes and related metabolic disorders.
NATURE COMMUNICATIONS
(2021)
Article
Food Science & Technology
Maojun Yao, Hui Teng, Qiyan Lv, Huifang Gao, Tengming Guo, Yiwen Lin, Sihai Gao, Meihu Ma, Lei Chen
Summary: DHM exhibits significant anti-hyperglycemic and anti-hyperinsulinemic effects, possibly through the regulation of the AMPK/Akt/GSK-3 beta signaling pathway.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Multidisciplinary Sciences
Simeon Omale, Kennedy I. Amagon, Titilayo O. Johnson, Shaun Kennedy Bremner, Gwyn W. Gould
Summary: Diabetes is a growing health emergency, causing economic burden and requiring more cost-effective therapies. This review explores the use of plant-based compounds in diabetes management, discussing their effects on insulin signaling pathways and providing evidence from both animal studies and clinical trials, suggesting their potential as novel therapeutics for diabetes.
Article
Food Science & Technology
Hyo Hee Kim, Bipin Vaidya, Se-Young Cho, Joseph Kwon, Duwoon Kim
Summary: The anti-hyperglycemic activity of alginate oligosaccharide (AOS) was demonstrated in a hyperglycemic zebrafish model. AOS treatment reduced blood glucose levels and improved survival in hyperglycemic zebrafish by enhancing glucose oxidation and suppressing the lactic acid pathway.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Cell Biology
Yannan Xi, Benbo Song, Iris Ngan, Mark J. Solloway, Mark Humphrey, Yan Wang, Kalyani Mondal, Hao Wu, Wenhui Liu, Darrin A. Lindhout, Diana Li, Hugo Matern, Avantika Kekatpure, Raj Haldankar, Daniel D. Kaplan, Hong Yang, Ophelia Pedersen, Anna Chen, Mei Zhou, Bethany Winans, Wei Guo, Alan Kutach, Marie Fanget, Michael Fox, Jie Tang, Jiping Zha, Husam Younis, David Shen, Alex DePaoli, Hui Tian, Zhonghao Liu
Summary: Anti-glucagon receptor antibody can induce beta-cell regeneration, reversing diabetes and restoring insulin levels. This therapy is effective in mouse models and non-human primates.
Article
Medicine, General & Internal
Jeeyon Rim, Julia Gallini, Christine Jasien, Xiangqin Cui, Lawrence Phillips, Aaron Trammell, Ruxana T. Sadikot
Summary: This study examined the association between outpatient use of oral anti-diabetic drugs (OADs) and hospital admissions for infections. The results showed that metformin was associated with a lower risk of hospital admission for infection, while other classes of OADs were associated with a higher risk.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Materials Science, Biomaterials
Zhaoyang Guo, Haiyang Liu, Zhekun Shi, Lulu Lin, Yinping Li, Miao Wang, Guoqing Pan, Yifeng Lei, Longjian Xue
Summary: In this study, a glucose-responsive insulin-releasing hydrogel microneedle dressing was developed for diabetic wound healing. The microneedle dressing exhibited mechanical stability, biocompatibility, glucose-responsive insulin release, and improved blood glucose control, making it effective for diabetic wound management and potentially useful for other chronic skin injuries.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Kheirollahzadeh, Elahe Eftekhari, Marzieh Ghollasi, Payam Behzadi
Summary: This study investigated the effect of Eryngium billardierei on insulin-resistance induced HepG2 cells. The results showed that 1 mg/mL E. billardierei had no toxicity on cells and increased the expression of IR, while reducing the levels of G6Pase and PEPCK.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Endocrinology & Metabolism
Marcello C. Laurenti, Chiara Dalla Man, Ron T. Varghese, James C. Andrews, John G. Jones, Cristina Barosa, Robert A. Rizza, Aleksey Matveyenko, Giuseppe De Nicolao, Kent R. Bailey, Claudio Cobelli, Adrian Vella
Summary: The study showed that characteristics of pulsatile insulin secretion do not correlate with hepatic and peripheral insulin sensitivity in nondiabetic humans, even when considered independently of other factors.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Oncology
Jiabing Zhan, Chen Chen, Dao Wen Wang, Huaping Li
Summary: Cardiovascular diseases are the leading cause of death in individuals with diabetes, with diabetic cardiomyopathy as a major complication. Hyperglycemia triggers multiple pathways leading to pathological changes in the heart. Intensive glycemic control does not reduce hospitalization and mortality in heart failure patients with diabetes, indicating a persistent hyperglycemic stress known as the hyperglycemic memory phenomenon.
FRONTIERS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
A. Sun, O. Simsek Papur, E. Dirkx, L. Wong, T. Sips, S. Wang, A. Strzelecka, M. Nabben, J. F. C. Glatz, D. Neumann, J. J. F. P. Luiken
Summary: The study identified PI4KIII beta as a positive and selective regulator of GLUT4 translocation in response to contraction-like signaling, suggesting it as a promising target to rescue defective glucose uptake in diabetics.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Engineering, Electrical & Electronic
Shuai Chen, Dongzhi Zhang, Yan Yang, Xiaoshuang Song
Summary: A high sensitivity, low cost non-enzymatic glucose sensor was successfully developed on a printed circuit board substrate, showing excellent sensor performance and application prospects.
IEEE SENSORS JOURNAL
(2021)
Article
Chemistry, Applied
Shiguo Tang, Chao Fang, Yuting Liu, Lihua Tang, Yuanyi Xu
Summary: The study found that ursolic acid has an anti-obesity effect on high-fat diet-induced obese rats. It alters glucose metabolism by regulating insulin and JNK signaling pathways, suppresses pancreatic oxidative stress, promotes pancreas regeneration, and decreases blood lipid and glucose levels.
JOURNAL OF OLEO SCIENCE
(2022)
Article
Nutrition & Dietetics
Jahanzaib Azhar, Peter John, Attya Bhatti
Summary: This study investigated the therapeutic potential of Thymus serpyllum in treating diabetic mice. The results demonstrated that oral administration of the aqueous extract of Thymus serpyllum effectively controlled hyperglycemia, improved glucose and insulin tolerance, and attenuated hyperglycemia in the liver muscle of streptozotocin (STZ)-induced diabetic mice via upregulation of AMPK and IRS1 gene expression.
Article
Food Science & Technology
Hikari Hirakida, Shinsuke Nakamura, Satoshi Inagaki, Shohei Tsuji, Masahiro Hayashi, Masamitsu Shimazawa, Hideaki Hara
Summary: This study evaluated the antidiabetic effect of an astaxanthin-rich extract (ARE) derived from Paracoccus carotinifaciens on pancreatic beta cells. The extract was found to increase insulin secretion and protect against cell death, potentially through the control of mitochondrial superoxide production.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)