Article
Biophysics
Manoharan Murphy, K. Theyagarajan, Kathavarayan Thenmozhi, Sellappan Senthilkumar
Summary: A novel biosensor was developed for monitoring hydrogen peroxide concentration, based on the covalent immobilization of hemoglobin on a newly developed NIBA-IL/MWCNT/GCE platform. The biosensor demonstrated effective direct electrochemistry of hemoglobin, with low detection limit, high sensitivity, good stability, and reliable reproducibility.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Nanoscience & Nanotechnology
Linyi Xu, Jing Li, Weishan Shi, Ning Bao, Chunmei Yu
Summary: The synthesis of MnCO3-Au hybrid microspheres and their application in electrochemical biosensing of hydrogen peroxide based on hemoglobin immobilization are reported. The microspheres exhibit unique properties that benefit direct electron transfer of Hb, with high performance and stability for H2O2 detection. The biosensor shows excellent selectivity, repeatability, and long-term stability, with potential for real sample analysis of H2O2.
Article
Materials Science, Characterization & Testing
Lidong Feng, Sheng Xiang, Yanlong Liu, Xinchao Bian, Gao Li, Xuesi Chen
Summary: An analytical method using gas chromatography with an internal standard was developed to quantitatively determine residual monomers in PLCL, which showed high precision with RSD less than 5.6% and 4.3% for LA and CL measurements, respectively. The recovery rate of standard addition for LA and CL in PLCL was between 96.5%-101.5% and 98.4%-104.2%, with RSD not exceeding 2.0%, indicating the method was sufficiently accurate.
Article
Chemistry, Physical
Yu Jun Yang, Songyang Chen, Ningya Wang, Panxiang Yang, Chenjia Jiang, Mengxiao Liu, Yao Cheng
Summary: In this study, rGO/hemoglobin/CdS biocomposite was prepared via a simple route and exhibited excellent electrocatalytic performance for the reduction of H2O2, with a linear calibration curve observed in a certain concentration range. The biocomposite showed direct electron transfer behavior and a detection limit of 6 x 10(-7) M for H2O2.
FULLERENES NANOTUBES AND CARBON NANOSTRUCTURES
(2022)
Article
Engineering, Chemical
Keziban Huner
Summary: Conductive polymers (P3ANA and PEDOT:PSS) were mixed with biocompatible and biodegradable PCL to prepare electrospun nanofibers. The nanofibers containing 10% P3ANA showed the highest antioxidant activity and were non-toxic to cells. The nanofiber with the highest amount of P3ANA also had a higher anodic current value than other P3ANA nanofibers.
POLYMER ENGINEERING AND SCIENCE
(2023)
Article
Electrochemistry
Subburayan Kalaiselvi, Deivasigamani Ranjith Kumar, Mahmudul Hasan, Jayadevan Santhanalakshmi, Devaraj Manoj, Mohammad Khalid, Jae-Jin Shim
Summary: In this study, a robust electrode platform was developed for the sensitive detection of hydrogen peroxide (H2O2) in human serum. The modified electrode exhibited high sensitivity and a wide linear range of H2O2 concentrations. It was successfully applied to analyze H2O2 in real human serum samples.
ELECTROCHIMICA ACTA
(2023)
Article
Materials Science, Textiles
Rezvan Mohamadinooripoor, Soheila Kashanian, Kobra Omidfar
Summary: Electrospun composite mats of PCL/PEE were used to fabricate PCL-PEE sutures with desirable mechanical and antibacterial properties. The sutures showed promising characteristics including sustained drug release, high tensile strength, antifungal effects, and accelerated wound healing.
FIBERS AND POLYMERS
(2023)
Article
Polymer Science
Victoria J. Barber, Meredith A. Borden, Jill W. Alty, Ly D. Tran, Hilmar Koerner, Luke A. Baldwin, Erik J. Alexanian, Frank A. Leibfarth
Summary: There is an increasing demand for degradable polymers in sustainable plastics and medical implants. To improve their usability, it is necessary to have a better understanding of degradation factors and develop new tools for modulation. In this study, poly(caprolactone) was modified through C-H xanthylation, resulting in changes in material properties and slower degradation. The interplay between molecular and materials characteristics was found to impact the degradation rate.
Review
Chemistry, Multidisciplinary
Yudong Xue, Yunting Wang, Zhenhua Pan, Kazuhiro Sayama
Summary: This paper reviews recent developments in EC/PEC H2O2 production through water oxidation, including fundamental aspects, benchmark activity evaluation, material/catalyst selection, and strategies for increasing selectivity, efficiency, and accumulation. The challenges and outlook for water oxidation in H2O2 production are also discussed, with a focus on device-level development, accumulation and stability, and industrial applications. The review aims to inspire further research in improving EC/PEC H2O2 production.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Hongwen Sun, Jiachun Feng
Summary: The study investigated the nucleation effect of the synthesized nucleating agent Ca-HHPA on PCL by different thermal treatments. The results showed that Ca-HHPA80-200 had a significantly improved nucleation efficiency compared to Ca-HHPA80 under similar dosages.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Polymer Science
Xing Li, Wenqing Xu, Xiaohua Chang, Ying Zheng, Lingling Ni, Guorong Shan, Yongzhong Bao, Pengju Pan
Summary: This study reports on the controlled synthesis, stepwise crystallization kinetics, and crystallization-induced microphase separation and structural evolution of a novel end-functionalized supramolecular polymer PCL-Thy. The double-crystalline nature of PCL-Thy was observed, with thymine units and PCL blocks crystallizing and melting in a sequential manner. This work provides important insights into crystallization-induced microphase separation and hierarchical ordering in double-crystalline supramolecular polymers.
Article
Chemistry, Physical
Alena Opalkova Siskova, Katarina Mosnackova, Marta Musiol, Andrej Opalek, Maria Buckova, Piotr Rychter, Anita Eckstein Andicsova
Summary: Packaging materials made of antimicrobial poly(epsilon-caprolactone) (PCL) can reduce food waste and improve the freshness and shelf life of fruits and vegetables.
Article
Biotechnology & Applied Microbiology
Sen-Lin Chang, Hang Li, Jia-Ning Liu, Ming-Xia Zhao, Ming-Hui Tan, Peng-Wei Xu, Xiao-dong Wang, Li-Wei Wang, Xiao-Fan Yuan, Qing-Sheng Zhao, Bing Zhao
Summary: This study demonstrated that decolorizing epsilon-PL with hydrogen peroxide is effective in maintaining its antibacterial activity while improving its appearance. The hydrogen peroxide treatment is a promising method to enhance product aesthetics, reduce decolorization costs, and broaden applications in the food and cosmetics industry.
BIOCHEMICAL ENGINEERING JOURNAL
(2021)
Article
Chemistry, Applied
Aoi Nakashima, Kaho Kohori, Kazuya Yamamoto, Jun-ichi Kadokawa
Summary: Chitin hexanoate-graft-poly(epsilon-caprolactone) (ChHex-g-PCL) was found to be thermoplastic, and the thermoplasticity was confirmed by the formation of a melt-pressed film. Chitin hexanoates were prepared by hexanoylation of chitin and then the surface-initiated ring-opening graft polymerization of epsilon-caprolactone was conducted to graft PCL chains onto the hydroxy groups of chitin hexanoates. The molar substitution and degree of polymerization of the PCL graft chains were influenced by the catalyst, reaction time, and degree of substitution.
CARBOHYDRATE POLYMERS
(2022)
Article
Engineering, Environmental
Matias Menossi, Florencia Salcedo, Nazarena Rivilli, Andres Torres Nicolini, Vera A. Alvarez, Leandro N. Luduena
Summary: Novel formulations based on corn starch, thermoplastic starch, poly (lactic acid), and poly (epsilon-caprolactone) were developed for agricultural mulch films. The addition of poly (epsilon-caprolactone) had slight effects on the properties of PLA/CS and PLA/TPS blends. Bioassays showed that the use of these biodegradable mulch films based on PLA/CS and PLA/TPS had positive effects on the growth of tomato plants, comparable to low-density polyethylene.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Jieni Fu, Xiangmei Liu, Zhenduo Cui, Yufeng Zheng, Hui Jiang, Yu Zhang, Zhaoyang Li, Yanqin Liang, Shengli Zhu, Paul K. Chu, Kelvin Wai Kwok Yeung, Shuilin Wu
Summary: Probiotic-based nanoparticles can effectively treat immunocompetent primary and immunocompromised secondary bacterial pneumonia by restoring host immunity. These nanoparticles can kill common pathogens, modulate lung microbiota, and alleviate overactive immune responses. This research provides a new strategy for treating bacterial pneumonia in individuals with normal and compromised immunity.
NATIONAL SCIENCE REVIEW
(2023)
Review
Materials Science, Multidisciplinary
Zhaojun Jia, Xiaoxue Xu, Donghui Zhu, Yufeng Zheng
Summary: Trauma-and disease-related skeletal defects and illnesses are causing problems for millions of people, particularly in an aging world. The convergence of additive manufacturing (AM) and bone tissue engineering (BTE) has opened up the era of personalized bone healthcare, by using design, printing, and engineering to create custom 3D architected scaffolds. This review provides an overview of theories, advances, and trends in this field, covering biomaterials, computational tools, and engineering processes. The goal is to produce customized and biomimetic (bio)scaffolds for next-generation bone healthcare.
PROGRESS IN MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Qunle Ouyang, Yuxuan Zeng, Yi Yu, Lei Tan, Xiangmei Liu, Yufeng Zheng, Shuilin Wu
Summary: This study explores the sonocatalytic properties of TiO2 nanoparticles with different phases and finds that anatase-brookite TiO2 has the best antibacterial efficiency. It provides a new noninvasive and efficient treatment strategy for wound biofilm infection.
Article
Materials Science, Multidisciplinary
Julietta V. Rau, Angela De Bonis, Roberto Teghil, Mariangela Curcio, Inna V. Fadeeva, Katia Barbaro, Massimo Di Menno Di Bucchianico, Marco Fosca, Yufeng Zheng
Summary: In this study, a biodegradable alloy of zinc-lithium (Zn-Li) was coated with a resorbable tricalcium phosphate (Mn,Sr-TCP) doped with manganese and strontium using the Pulsed Laser Deposition method. The coating was characterized using various techniques, and microbiology experiments were performed to test the growth inhibition of bacteria strains and fungus. The results showed that the Mn,Sr-TCP-coated Zn-Li samples exhibited about 10% inhibition on the growth of all four bacteria strains and had the most pronounced effect on Candida albicans fungus (about 50% inhibition of growth). The prepared coatings have the potential to improve the degradation behavior and biological characteristics of Zn-Li alloys.
Article
Chemistry, Physical
Yuxuan Zeng, Qunle Ouyang, Yi Yu, Lei Tan, Xiangmei Liu, Yufeng Zheng, Shuilin Wu
Summary: Sonodynamic therapy (SDT) has attracted attention for treating deep-seated tumors or infections due to its non-invasiveness and high tissue-penetrating ability. This study develops a defective homojunction porphyrin-based metal-organic framework (MOF) that greatly enhances sonocatalytic ability for SDT of MRSA-infected osteomyelitis. The MOF structure is modified using acetic acid and benzoic acid, and the defect-induced homojunction structure is found to improve the SDT effect by enhancing ultrasound-triggered reactive oxygen species production.
Article
Engineering, Biomedical
Yingchao Su, Jiayin Fu, Juncen Zhou, Elias Georgas, Shaokang Du, Yi-Xian Qin, Yadong Wang, Yufeng Zheng, Donghui Zhu
Summary: Zinc (Zn) is a bioresorbable metal that has potential applications in cardiovascular stent material, orthopedic implants, wound closure devices, etc. However, pure Zn is not ideal for these applications due to its low mechanical strength and localized degradation behavior. This study explores the alloying of Zn with selective transition metals (vanadium-V, chromium-Cr, and zirconium-Zr) to improve its properties. The blended alloys showed improved mechanical strength, suitable degradation rate, and acceptable biocompatibility, making them potential candidates for bioresorbable medical implants.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Xinghui Wei, Wenhao Zhou, Zhen Tang, Hao Wu, Yichao Liu, Hui Dong, Ning Wang, Hai Huang, Shusen Bao, Lei Shi, Xiaokang Li, Yufeng Zheng, Zheng Guo
Summary: This study enhanced the osseointegration capacity of PEEK materials through porous structural design and activated surface modification. The activated surface promoted cell proliferation, adhesion, osteoblast differentiation, and mineralization. The porous PEEK scaffolds facilitated vascular ingrowth and bone ingrowth, and the released Mg2+ accelerated early bone ingrowth by promoting angiogenesis.
BIOACTIVE MATERIALS
(2023)
Article
Engineering, Biomedical
Wenhao Zhou, Tian Bai, Lan Wang, Yan Cheng, Dandan Xia, Sen Yu, Yufeng Zheng
Summary: The combination of antimicrobial peptides and silver nanoparticles in a silk fibroin-based coating showed excellent infection-triggered antibacterial and osteointegration properties. The coating displayed sensitive pH-responsive behavior and a high antibacterial rate. In vivo experiments demonstrated enhanced osseointegration compared to untreated titanium implants.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Hongtao Yang, Dawei Jin, Jiancun Rao, Jiahui Shi, Guannan Li, Cheng Wang, Kai Yan, Jing Bai, Guo Bao, Meng Yin, Yufeng Zheng
Summary: In order to reduce the occurrence of restenosis and thrombosis in stents, it has been clinically proven that using a thinner-strut stent is effective. Therefore, there is a current trend towards using ultrathin-strut (<= 70 μm) designs for durable stents. However, stents made from biodegradable platforms have not been able to achieve breakthroughs across generations due to their excessively thick struts.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Jun Li, Chaofeng Wang, Shuilin Wu, Zhenduo Cui, Yufeng Zheng, Zhaoyang Li, Hui Jiang, Shengli Zhu, Xiangmei Liu
Summary: Currently, developing a self-disinfecting coating on touchscreens has become an urgent and meaningful task due to the increased public attention toward the spread of pathogenic viruses and bacteria. In this study, a ZnO-Fe2O3 superlattice nanofilm with engineered electronic defects is designed via atomic layer deposition for photocatalytic bactericidal and virucidal touchscreen. The nanofilm exhibits high antibacterial and antiviral efficacy (>90%) against drug-resistant bacteria and H1N1 viruses under simulated solar or low-power LED light irradiation, while also demonstrating excellent light transmission (>90%), abrasion resistance, and biocompatibility on touchscreens.
ADVANCED MATERIALS
(2023)
Article
Engineering, Multidisciplinary
Pengxia Li, Bo Li, Caofeng Wang, Xiaoyan Zhao, Yufeng Zheng, Shuilin Wu, Jie Shen, Yu Zhang, Xiangmei Liu
Summary: Pathogenic bacterial infection and drug resistance pose a serious threat to human health. Phototherapy has emerged as a noninvasive and drug resistance-free approach for treating tissue infections. In this study, a Cu co-coordinated donor-acceptor type co-valent organic framework-like hydrogel was developed for the treatment of wound infection. The hydrogel exhibited photocatalytic and anti-inflammatory properties, achieving high bactericidal activity against Staphylococcus aureus and Escherichia coli under light irradiation. In vivo tests further demonstrated its ability to promote wound healing and tissue regeneration. This photocatalytic hydrogel offers a promising strategy for rapid reconstruction of infected tissues.
COMPOSITES PART B-ENGINEERING
(2023)
Article
Materials Science, Multidisciplinary
Chenxi Dou, Mingyang Zhang, Dechun Ren, Haibin Ji, Zhe Yi, Shaogang Wang, Zengqian Liu, Qiang Wang, Yufeng Zheng, Zhefeng Zhang, Rui Yang
Summary: A Mg-Ti composite with a bi-continuous and mutually interspersed architecture has been fabricated, showing potential as a new partially degradable and bioactive implant material.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yuqian Qiao, Shuilin Wu, Yufeng Zheng, Chaofeng Wang, Zhaoyang Li, Yu Zhang, Shengli Zhu, Hui Jiang, Zhenduo Cui, Xiangmei Liu
Summary: Microwave (MV)-trigged dynamic therapy using MV-responsive materials shows promise for treating deep infection diseases, including life-threatening osteomyelitis, that are not effectively treated by antibiotics. Surface states of materials play a key role in the generation of free charges and the MV dynamic effects. A new MV responsive system, consisting of a 2D metal-organic framework (2D MOF) on oxidized carbon nanotube (CNT), is developed, which exhibits highly effective antimicrobial activity and eradicates Staphylococcus aureus infected rabbit tibia osteomyelitis under MV irradiation. This study represents a major advancement in antibiotic-free MV therapy for deep tissue bacterial infection.
Article
Chemistry, Multidisciplinary
Yuan Li, Shuilin Wu, Yufeng Zheng, Zhaoyang Li, Zhenduo Cui, Hui Jiang, Shengli Zhu, Xiangmei Liu
Summary: Interlayer interactions in 2D materials play a crucial role in promoting catalytic performance. This study demonstrates that asymmetric doping of metal nanoparticle clusters in g-C3N4 enhances catalytic efficiency by inducing microwave excitation of interlayer electron delocalization, leading to improved interlayer migration and enhanced microwave disinfection and pneumonia therapy. Hence, structurally modulated asymmetric doping of 2D materials can provide effective solutions for microwave-based disinfection and pneumonia therapy.
Article
Engineering, Biomedical
Junlong Tan, Shuang Li, Chaoyang Sun, Guo Bao, Meijing Liu, Zehao Jing, Hanwei Fu, Yanhua Sun, Qingmin Yang, Yufeng Zheng, Xiaogang Wang, Hongtao Yang
Summary: Zn biodegradation induces a consistent, dose-dependent spatioteporal response in angiogenesis, both in vivo and in vitro. The concentration of degradation products tends to spread in a decreasing direction centered on the implant. Meanwhile, vasularization significantly increases at a distance of 100-200 mu m from the implant. Vascular endothelial cells show similar effects being affected by different doses of Zn extraction.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biophysics
Reza Khodadadi, Manouchehr Eghbal, Hamideh Ofoghi, Alireza Balaei, Ali Tamayol, Karen Abrinia, Amir Sanati-Nezhad, Mohamadmahdi Samandari
Summary: This paper introduces an integrated portable centrifugal microfluidic system that automates cell and fluid manipulation for complete blood counting (CBC) analysis at the point-of-care (POC). The system utilizes a specially designed microfluidic disc for cell separation, solution metering and mixing, and cell counting, and is equipped with a custom script for automated quantification of cells. The proposed method shows a strong correlation with the gold standard hematology analyzer for various blood parameters. The portable system offers simplicity, affordability, and low power consumption, making it a potential solution for improving healthcare delivery in resource-limited settings and remote areas.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Nabil H. Bhuiyan, Joon S. Shim
Summary: Developing herd immunity is crucial for changing the course of the COVID-19 pandemic. An AI-driven point-of-care testing platform has been proposed for analyzing the body's response to SARS-CoV-2, and it has been successfully used for quantifying viral proteins and antibodies in blood samples. A data-receptive web-based dashboard system has also been developed for real-time analysis of herd immunity progress.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Alexiane Godain, Timothy M. Vogel, Pascal Fongarland, Naoufel Haddour
Summary: This study provides comprehensive insights into the intricate relationship between shear stress and electroactive biofilms in microbial fuel cells, highlighting the pivotal role of shear stress in influencing the growth kinetics, electrical performance, and physical structure of the biofilms. The study also emphasizes the complexities of extracellular electron transfer mechanisms and the need for complementary metaproteomic analyses.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Linjie Wang, Yixin Chen, Yang Ji, Shujun Zheng, Fei Wang, Caolong Li
Summary: A paper-based biosensor incorporating surface-enhanced Raman spectroscopy (SERS) and colorimetric detection has been developed for efficient quantification of intracellular glutathione (GSH). The biosensor exhibits excellent selectivity, stability, and precision, with low detection limits in both SERS and colorimetric modes. It has been successfully utilized for intracellular GSH detection and validated against a commercial GSH assay kit.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Quan Zhou, Jing Wang, Zhen Zhang, Alain Wuethrich, Richard J. Lobb, Matt Trau
Summary: This study presents a biosensor for sensitive detection of EMT-associated biomarkers on extracellular vesicles (EVs) surfaces during targeted therapy. Through longitudinal monitoring of patients, the biosensor shows its ability to identify the EMT-like phenotype switching on circulating EVs during the development of resistance.
BIOSENSORS & BIOELECTRONICS
(2024)
Review
Biophysics
Pratika Rai, Sabrina N. Hoba, Celine Buchmann, Robert J. Subirana-Slotos, Christian Kersten, Tanja Schirmeister, Kristina Endres, Bernd Bufe, Alexey Tarasov
Summary: Proteases have been proposed as potential biomarkers for various pathological conditions. The development of protease biosensors offers a more efficient way to investigate dysregulated proteases. This review article presents different optical and electrochemical detection methods for designing biosensors for all major protease families.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Chengxin Liu, Xu Shen, Li Yan, Runlian Qu, Yue Wang, Yaqin He, Zixuan Zhan, Piaopiao Chen, Feng Lin
Summary: In this study, a homogeneous rapid electrochemical aptasensor was developed to quantitatively detect CTCs in lung cancer patients. The aptasensor utilized a DNA nanosphere structure and a complementary aptamer to specifically detect mucin 1 as a marker for CTCs. The assay exhibited high specificity and sensitivity, and the results were consistent with other detection methods.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Danni Xue, Xing Dai, Jialong Zhao, Jiayao Zhang, Huan Liu, Kui Liu, Tao Xu, Chenjie Gu, Xingfei Zhou, Tao Jiang
Summary: In this study, a dual-enhancement SERS substrate based on Ti3C2TX and Ag nanocubes was fabricated for precise quantification of ritonavir and ibrutinib in serum. The formation of numerous electromagnetic hotspots between Ag nanocubes facilitated effective photo-induced charge transfer. The composite substrate showed excellent sensitivity, achieving low detection limits and high recoveries, making it promising for monitoring and identification of clinical blood drug concentration.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Tenghua Zhang, Zihui Xie, Xiaohe Zheng, Yuxin Liang, Yao Lu, Hankang Zhong, Feiyang Qian, Yuqing Zhu, Ruiting Sun, Yan Sheng, Jiaming Hu
Summary: This study reports a technology based on cationic lipid-polymer hybrid nanoparticles for efficient extracellular vesicle (EV) enrichment and in-situ detection of internal microRNAs. The technology demonstrates high EV enrichment efficiency and sensitive internal RNA detection, making it potentially useful for early pancreatic cancer diagnosis.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Wenjie Dai, Gaoxu Chen, Xiaoyan Wang, Shujun Zhen, Chengzhi Huang, Lei Zhan, Yuanfang Li
Summary: In this study, a novel metal organic gel (MOG) with dual electrochemiluminescence (ECL) properties was prepared by simple mixing. The MOG exhibited strong and stable anodic and cathodic ECL signals. By utilizing this MOG, an ECL resonance energy transfer (ECL-RET) biosensor was constructed for ultrasensitive detection of a specific gene. The study developed a straightforward technique for obtaining a single luminescent material with dual signals and expanded the analytical application of MOGs in the realm of ECL.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Lais Canniatti Brazaca, Amanda Hikari Imamura, Rodrigo Vieira Blasques, Jessica Rocha Camargo, Bruno Campos Janegitz, Emanuel Carrilho
Summary: The use of microfluidic paper-based analytical devices (muPADs) for medical diagnosis is a growing trend due to their low cost, easy use, simple manufacturing, and potential for application in low-resource settings. This review focuses on the advances in muPADs for medical diagnostics, discussing their use in detecting various biomarkers in common human biofluids. The challenges of biomarker detection in each sample are examined, along with innovative techniques to overcome these limitations. The commercialization difficulties of muPADs are also considered, along with future trends such as wearable devices and integrated platforms.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Minghong Jian, Xudong Sun, Hua Zhang, Xiaotong Li, Shasha Li, Zhenxin Wang
Summary: Matrix metalloproteinases (MMPs) are attractive biomarkers for cancer diagnosis and treatment, but their low abundance in biological samples, especially in the early stages of tumors, makes it challenging to precisely analyze MMP activities. In this study, a peptide microarray-based metal-enhanced fluorescence assay (PMMEFA) is proposed as a sensitive and specific method to simultaneously detect MMP-1, -2, -3, -7, -9, and -13 activities. The PMMEFA showed excellent sensitivity and was capable of detecting MMP activities in various matrices.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Kyung Ho Kim, Eunsu Ryu, Zinah Hilal Khaleel, Sung Eun Seo, Lina Kim, Yong Ho Kim, Hyun Gyu Park, Oh Seok Kwon
Summary: We have developed a novel strategy for discriminative detection of SARS-CoV-2 variants using the plasmonic photothermal effect of gold nanofilms and digital polymerase chain reaction (dPCR) technology. With this method, we were able to detect the delta and omicron variants with high sensitivity within 25 minutes from COVID-19 patients' clinical samples, making it a rapid and accurate point-of-care testing tool.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Zepeng Kang, Yuanming Wang, Haiyan Song, Xueli Wang, Job Zhang, Zhiguang Zhu
Summary: By designing a wearable and flexible lactic-acid/O2 EBFC with an air-breathing biocathode, the limitations of biocathode are effectively solved. The optimal performance conditions are determined through experiments, and the EBFC is successfully applied to power a low-power device.
BIOSENSORS & BIOELECTRONICS
(2024)
Article
Biophysics
Huayun Chen, Zhiheng You, Yuhui Hong, Xiao Wang, Mingming Zhao, Yushi Luan, Yibin Ying, Yixian Wang
Summary: This study developed a colorimetric sensor array using gas-responsive two-dimensional metal-organic framework (MOF) composites for highly sensitive detection of volatile organic compounds (VOCs). The dye/Zn-2(bim)(4) composites-based sensor arrays showed enhanced sensitivity and anti-interference properties. The findings demonstrate the potential use of dye/Zn-2(bim)(4) sensor arrays for early perception of plant diseases.
BIOSENSORS & BIOELECTRONICS
(2024)
