Enzyme kinetics and distinct modulation of the protein kinase N family of kinases by lipid activators and small molecule inhibitors

A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery

(2013) Yinghong Gao et al.   BIOCHEMICAL JOURNAL

Depletion of protein kinase N3 (PKN3) impairs actin and adherens junctions dynamics and attenuates endothelial cell activation

(2012) Kristin Möpert et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Site recognition and substrate screens for PKN family proteins

(2011) Alejandra Collazos et al.   BIOCHEMICAL JOURNAL

Phase I clinical development of Atu027, a siRNA formulation targeting PKN3 in patients with advanced solid tumors

(2011) Dirk Strumberg et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

Identification of an Interaction between the TPα and TPβ Isoforms of the Human Thromboxane A2Receptor with Protein Kinase C-related Kinase (PRK) 1

(2011) Elizebeth C. Turner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The interaction of PKN3 with RhoC promotes malignant growth

(2011) Keziban Unsal-Kacmaz et al.   Molecular Oncology

Functional Viability Profiles of Breast Cancer

(2011) R. Brough et al.   Cancer Discovery

The Rho Target PRK2 Regulates Apical Junction Formation in Human Bronchial Epithelial Cells

(2010) S. W. Wallace et al.   MOLECULAR AND CELLULAR BIOLOGY

Development of an intracellularly acting inhibitory peptide selective for PKN

(2009) Kazuhiro Shiga et al.   BIOCHEMICAL JOURNAL

Regulation of the Interaction between Protein Kinase C-related Protein Kinase 2 (PRK2) and Its Upstream Kinase, 3-Phosphoinositide-dependent Protein Kinase 1 (PDK1)

(2009) Rosalia Dettori et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase

(2009) S.-J. Kim et al.   JOURNAL OF VIRAL HEPATITIS

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY