Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 76, Issue 4, Pages 755-761Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.110868
Keywords
Sasa quelpaertensis; high-fat diet; AMP-activated protein kinase; anti-obesity; 3T3-L1 adipocytes
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Funding
- National Research Foundation of Korea (NRF)
- Ministry of Education Science and Technology [2010-0007021]
- Regional Innovation System of the Ministry of Knowledge Economy (MKE) of the Republic of Korea [B0012292]
- Ministry of Knowledge Economy (MKE), Republic of Korea [B0012292] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study explores the anti-obesity properties of a Sasa quelpaertensis leaf extract (SQE) in high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes. SQE administration with HFD for 70 d significantly decreased the body weight gain, adipose tissue weight, and serum total cholesterol and triglyceride levels in comparison with the HFD group. SQE administration also reduced the serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactate dehydrogenase, and the accumulation of lipid droplets in the liver, suggesting a protective effect against HFD-induced hepatic steatosis. SQE administration restored the NFU-induced decreases with phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in epididymal adipose tissue. SQE also induced AMPK phosphorylation in mature 3T3-L1 adipocytes. These results suggest that SQE exerted an anti-obesity effect on HFD-induced obese mice by activating AMPK in adipose tissue and reducing lipid droplet accumulation in the liver.
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