Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 75, Issue 8, Pages 1554-1556Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.110234
Keywords
Achillea millefolium; flower; guaianolide; isolation
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Funding
- National Natural Science Foundation of China [81072551]
- Scientific Research Foundation for Returned Overseas Chinese Scholars of Hebei Province [2006-02]
- Scientific Research Foundation of Hebei Province [08B032, C2010000489]
- Syngenta Ltd. [2008-Hebei Medical University-Syngenta-02]
- Japan Society for the Promotion of Science [22580112]
- Grants-in-Aid for Scientific Research [22580112] Funding Source: KAKEN
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Achillinin A (2 beta,3 beta-epoxy-l alpha,4 beta,10 alpha-trihydroxyguai-11(13)-en-12,6 alpha-olide, 1), a new guaianolide isolated from the flower of Achillea millefolium, exhibited potential antiproliferative activity to A549, RERF-LC-kj and QG-90 cells with 50% inhibitory concentration (IC50) values of 5.8, 10 and 0.31 mu m, respectively.
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