Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 75, Issue 5, Pages 891-898Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.100825
Keywords
Hypsizigus marmoreus; glycosidic linkage; molecular weight; anticancer; immunomodulating activity
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Funding
- Ministry of Education, Science, and Technology [KRF-2008-F00159]
- National Research Foundation of Korea [핵06B2509] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Water-soluble extracts isolated from Hypsizigns marmoreus and fractionated by ion-exchange chromatography were investigated to determine their molecular characteristics and biological activities. The crude and fractionated water-soluble extracts (F-1, F-2 and F-3) consisted mostly of carbohydrates (55.8-98.9%) with varied protein contents (1.1-23.0%). Their monosaccharide levels were significantly different, including the glucose content (67.0-100%) and galactose content (0-33.0%). The backbone of each fraction was mainly glucose molecules connected with 1,4-glycosidic linkages which contained considerable amounts of glucose and/or galactose connected through 1,6-glycosidic linkages. The average molecular weight (M-w) of the extracts varied considerably, ranging from 1,665 x 10(4) to 19 x 10(4) g/mol. Little cytotoxicity was apparent in cancer cell lines from the addition of these extracts; however, they significantly stimulated Raw 264.7 cells to release nitric oxide (NO) and prostaglandin E-2 (PGE(2)), suggesting their potential immunomodulating activities.
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