Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 75, Issue 6, Pages 1188-1190Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.100893
Keywords
bitterness; taste receptor; bitter peptide
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Funding
- Research and Development Program for New Bio-industry Initiatives of the Bio-oriented Technology Research Advancement Institution (BRAIN)
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22380072, 20380183]
- Japan Society for the Promotion of Science [LS037]
- Iijima Memorial Foundation for the Promotion of Food Science and Technology
- Grants-in-Aid for Scientific Research [22380072, 20380183, 23248058, 23688016] Funding Source: KAKEN
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The strong bitter peptide, Phe-Phe-Pro-Arg, activated cultured cells expressing either of the known human bitter taste receptors, hTAS2R8 and hTAS2R39. The partial structure of Pro-Arg activated hTAS2R39, but did not activate hTAS2R8. These receptors may not indiscriminately recognize bitter peptides, but have a differential function in their recognition.
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