Article
Endocrinology & Metabolism
Vasudha Ahuja, Pasi Aronen, T. A. Pramodkumar, Helen Looker, Angela Chetrit, Aini H. Bloigu, Auni Juutilainen, Cristina Bianchi, Lucia La Sala, Ranjit Mohan Anjana, Rajendra Pradeepa, Ulagamadesan Venkatesan, Sarvanan Jebarani, Viswanathan Baskar, Teresa Vanessa Fiorentino, Patrick Timpel, Ralph A. DeFronzo, Antonio Ceriello, Stefano Del Prato, Muhammad Abdul-Ghani, Sirkka Keinanen-Kiukaanniemi, Rachel Dankner, Peter H. Bennett, William C. Knowler, Peter Schwarz, Giorgio Sesti, Rie Oka, Viswanathan Mohan, Leif Groop, Jaakko Tuomilehto, Samuli Ripatti, Michael Bergman, Tiinamaija Tuomi
Summary: The 1-h PG of >= 11.6 mmol/L during OGTT has good sensitivity and specificity for detecting type 2 diabetes. Prescreening with a diabetes-specific risk calculator is suggested to reduce the proportion of false-positive cases, with further studies needed for other ethnic groups and complication risk assessment.
Article
Obstetrics & Gynecology
L. Hiersch, B. R. Shah, H. Berger, M. Geary, S. D. McDonald, B. Murray-Davis, J. Guan, I Halperin, R. Retnakaran, J. Barrett, N. Melamed
Summary: This study identified potential twin-specific OGTT thresholds for gestational diabetes mellitus that are associated with a similar risk of future type-2 diabetes to that observed in women diagnosed with GDM in singleton pregnancies based on standard OGTT thresholds.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Endocrinology & Metabolism
Feng Yu Kuo, Kai-Chun Cheng, Yingxiao Li, Juei-Tang Cheng
Summary: The oral glucose tolerance test (OGTT) is widely used for diagnosing impaired glucose tolerance and type 2 diabetes, as well as studying glucose utilization and insulin sensitivity. Recent clinical practice recommendations include using 30-min or 1-h post-glucose load glycemia. In basic research, the incremental area under the curve is not suitable for studies involving animals receiving repeated or chronic treatment.
WORLD JOURNAL OF DIABETES
(2021)
Article
Endocrinology & Metabolism
Anne Bonhoure, Kathryn J. Potter, Johann Colomba, Valerie Boudreau, Cindy Bergeron, Katherine Desjardins, Maite Carricart, Francois Tremblay, Annick Lavoie, Remi Rabasa-Lhoret
Summary: In cystic fibrosis patients, maximum OGTT glucose (Gmax) is strongly associated with the risk of developing CFRD; Gmax < 8 mmol/l may identify those at very low risk of future CFRD; additionally, individuals with higher Gmax are more likely to have pancreatic insufficiency, poor insulin secretory capacity, and impaired pulmonary function.
Article
Obstetrics & Gynecology
Tatiana A. Zaccara, Fernanda C. F. Mikami, Cristiane F. Paganoti, Rossana P. Francisco, Rafaela A. Costa
Summary: The study found that there are distinct characteristics in pregnant women with gestational diabetes who require insulin treatment, such as higher BMI, history of previous gestational diabetes, and chronic hypertension. By analyzing patient data, we can predict the risk of needing insulin treatment, which can help allocate resources and provide closer follow-up to high-risk patients.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Medicine, General & Internal
Wei-Lin Chen, Wayne Huey-Herng Sheu, Yu-Hsuan Li, Jun-Sing Wang, Wen-Jane Lee, Kae-Woei Liang, Wen-Lieng Lee, I-Te Lee
Summary: This study assessed the impact of abnormal glucose regulation on long-term cardiovascular outcomes in patients with coronary artery disease. The results showed that diabetes detected via oral glucose tolerance test (OGTT) was significantly associated with an increased risk for composite endpoints, while prediabetes was not significantly associated. The 2-hour postload glucose measurement provided a greater predictive power for the composite endpoint compared to fasting glucose and HbA1c.
Article
Medicine, General & Internal
Esther Maor-Sagie, Mordechai Hallak, Yoel Toledano, Rinat Gabbay-Benziv
Summary: This study aimed to evaluate the association between oGTT performed after 28 weeks and the risk of T2DM. The results showed that late oGTT had lower rates of GDM and T2DM. However, once GDM was diagnosed, regardless of oGTT timing, the risk of T2DM was increased.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Selina Balke, Petra Weid, Laura Fangmann, Paul Rostin, Wolfgang Henrich, Josefine Theresia Koenigbauer
Summary: This study analyzed data from 1664 patients with gestational diabetes (GDM) and found a strong correlation between glucose levels in the 75 g oGTT and adverse perinatal fetomaternal outcomes. Three subtypes of GDM were identified based on glucose levels, and significant differences were observed in baseline characteristics, insulin therapy, mode of delivery, and fetal growth among the subgroups. The findings suggest the need for individualized prenatal care after a GDM diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
T. Uchida, T. Teramoto, S. Fukizawa, H. Kato, Y. Nonaka, M. Suematsu, N. Murayama
Summary: The study aimed to classify Japanese adults without diabetes into four categories based on the oral glucose tolerance test (OGTT) and characterize their insulin sensitivity and secretion. The results showed that each category had different characteristics in terms of glucose metabolism, age, sex distribution, and other clinical values.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Basilio Pintaudi, Giacoma Di Vieste, Rosario D'Anna, Francesca Chiereghin, Emilia Biamonte, Francesco Corrado, Antonino Di Benedetto
Summary: This study assessed the analytical reliability of the Oral Glucose Tolerance Test (OGTT) for the diagnosis of gestational diabetes mellitus (GDM). The results indicate that the OGTT is not completely accurate for GDM diagnosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Endocrinology & Metabolism
Emily A. Rosenberg, Ellen W. Seely, Kaitlyn James, Marti D. Soffer, Stacey Nelson, Jacinda M. Nicklas, Camille E. Powe
Summary: The study found no association between carbohydrate intake and post-OGTT glucose levels among postpartum individuals. Therefore, dietary preparation prior to the OGTT may not be necessary in this population.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Shaofeng Huo, Liang Sun, Geng Zong, Xia Shen, He Zheng, Qianlu Jin, Huaixing Li, Huiyong Yin, Xu Lin
Summary: This study aimed to characterize plasma metabolomic profiles during an oral glucose tolerance test (OGTT) in Chinese individuals with different glycemic statuses. The results showed distinct metabolite responses in individuals with type 2 diabetes (T2D), with certain metabolites significantly higher at 2 hours post-OGTT. Differences in metabolite levels were also observed between T2D, prediabetes, and normal glucose subjects, suggesting potential implications for glucose homeostasis.
Article
Medicine, Research & Experimental
Teresa Mezza, Pietro Manuel Ferraro, Gianfranco Di Giuseppe, Simona Moffa, Chiara M. A. Cefalo, Francesca Cinti, Flavia Impronta, Umberto Capece, Giuseppe Quero, Alfredo Pontecorvi, Andrea Mari, Sergio Alfieri, Andrea Giaccari
Summary: This study aimed to verify the acute effect of reduced beta cell mass on the development of hyperglycemia. The research found that reduced first-phase insulin secretion and glucose sensitivity were predictors of eventual development of impaired glucose tolerance and diabetes. Thus, these functional alterations may play a key role in the pathogenesis of type 2 diabetes (T2DM).
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, General & Internal
Hyun-Hwa Cha, Won Ki Lee, Sujeong Kim, Hyun Mi Kim, Mi Ju Kim, Won Joon Seong
Summary: We aimed to determine the upper and lower cutoff values to simplify the diagnosis of gestational diabetes mellitus (GDM). By investigating OGTT results, we found the cutoff values for confirming and excluding GDM, and discovered a method to simplify the diagnostic steps.
Article
Endocrinology & Metabolism
Lewin Small, Amy Ehrlich, Jo Iversen, Stephen P. Ashcroft, Kajetan Trost, Thomas Moritz, Bolette Hartmann, Jens J. Holst, Jonas T. Treebak, Juleen R. Zierath, Romain Barres
Summary: The study compares the effect of different routes of glucose administration (oral and intraperitoneal) on glucose and insulin kinetics during a glucose tolerance test in mice. The results show that intraperitoneal glucose administration resulted in significantly elevated blood glucose levels, but had a lesser effect on insulin and incretin hormone levels compared to oral administration.
MOLECULAR METABOLISM
(2022)
