4.4 Article

Antimicrobial Activity of Stereoisomers of Morinols A and B, Tetrahydropyran Sesquineolignans

Journal

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 73, Issue 1, Pages 129-133

Publisher

TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.80536

Keywords

neolignan; tetrahydropyran neolignan; antimicrobial activity

Funding

  1. Ehime University
  2. Marutomo Co.

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The antimicrobial activity of all stereoisomers of morinols A and B was tested. All stereoisomers of morinols A and B showed antifungal activity against Alternaria alternata, especially (-)-morinol B which showed the strongest activity. The natural component, (+)-morinol A, and unnatural stereoisomer, (7S,7'S,8R,8'R)-morinol B, showed antibacterial activity against the gram-positive bacteria, Bacillus subtilis and Listeria denitrificans.

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