Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 73, Issue 7, Pages 1685-1689Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.90032
Keywords
delphinidin; beta-amyloid; calcium influx; tau hyperphosphorylation; PC12 cells
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Funding
- Korea Science and Engineering Foundations
- Ministry of Science and Technology
- National Research Foundation of Korea [2008-0062500] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Beta-amyloid (A beta) has been suggested to induce neurotoxicity in Alzheimer's disease. We evaluated the neuroprotective effects of delphinidin, an anthocyanidin commonly present in pigmented fruits and vegetables, against A beta-induced toxicity. A beta (25-35) significantly decreased the viability of PC12 cells, and this was accompanied by an increase in intracellular calcium levels and tau phosphorylation. However, treatment with delphinidin rescued PC12 cells from A beta by attenuating the elevation of intracellular calcium levels and tau phosphorylation. Taken together, these results suggest that delphinidin protects PC12 cells against A beta-induced toxicity by attenuating intracellular calcium influx and tau hyperphosphorylation.
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