Journal
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
Volume 73, Issue 12, Pages 2787-2789Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1271/bbb.90599
Keywords
chronological lifespan; yeast; Ecl1 family
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan Science and Technology Agency
- Nagase Science and Technology Foundation
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We found that YGR146C of Saccharomyces cerevisiae encodes a functional homolog of Ecl1 that is involved in the chronological lifespan of Schizosaccharomyces pombe. When YGR146C is overexpressed, it extends the viability of wild-type S. cerevisiae cells after entry into the stationary phase, as in the case of Ecl1. We propose that Ecl1 family proteins are novel regulatory factors involved in chronological lifespan among yeasts.
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