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Effects of a casein hydrolysate prepared from Aspergillus oryzae protease on adjuvant arthritis in rats

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2008)

Journal

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Volume 72, Issue 8, Pages 1983-1991

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TAYLOR & FRANCIS LTD

DOI: 10.1271/bbb.70792

Keywords

casein hydrolysate; Aspergillus oryzae protease; adjuvant arthritis; nitric oxide; prostaglandin E-2

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Abstract

We evaluated the effects of a casein hydrolysate (CH) prepared from Aspergillus oryzae protease on rat adjuvant arthritis, a model of human rheumatoid arthritis. CH was administered orally once a day to the animals for 22d after the adjuvant injection. CH suppressed swelling in the adjuvant-uninjected hind paws, and a higher dose of CH suppressed the increase in arthritic score and swelling of the adjuvant-injected hind paws. A histopathological examination revealed evidence that the higher dose of CH suppressed the articular changes in the rats. In addition, CH suppressed the production of nitric oxide and prostaglandin E-2 in the plasma of the rats. These results suggest that CH had a suppressive effect on adjuvant arthritis by inhibiting the acute and chronic inflammatory reactions.

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Antioxidant Activity of Novel Casein-Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells

Xiao Zhao, Ya-Juan Cui, Sha-Sha Bai, Zhi-Jie Yang, Miao-Cai, Sarah Megrous, Tariq Aziz, Abid Sarwar, Dong Li, Zhen-Nai Yang

Summary: Casein-derived antioxidant peptides obtained by using a combination of two microbial proteases exhibited different levels of antioxidant activity by protecting cells against oxidative damage, activating antioxidant enzymes and the Nrf2 signaling pathway. These peptides could potentially serve as antioxidant agents in functional foods or pharmaceutical preparations.

JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY (2021)

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Article Chemistry, Physical

Purification and Characterization of Aspartic Protease Produced from Aspergillus oryzae DRDFS13 MN726447 under Solid-State Fermentation

Jermen Mamo, Martin Kangwa, Jorge Fernando Suarez Orellana, Vikas Yelemane, Hector Marcelo Fernandez-Lahore, Fassil Assefa

Summary: Aspartic proteases with catalytic activity depending on aspartic acid residues were purified and characterized from locally identified fungi. The enzyme showed high milk-clotting and protease activity, and could potentially serve as a substitute source of rennet enzyme for cheese production. Optimal conditions for enzyme activity were determined, and the enzyme exhibited stability at specific pH and temperature ranges.

CATALYSIS LETTERS (2022)

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Article Plant Sciences

Tunisian Olea europaea L. leaf extract suppresses Freund's complete adjuvant-induced rheumatoid arthritis and lipopolysaccharide-induced inflammatory responses

Yo Han Hong, Chaoran Song, Kon Kuk Shin, Eunju Choi, So-Hyeon Hwang, Young-Jin Jang, Amani Taamalli, Jinwhoa Yum, Jong-Hoon Kim, Eunji Kim, Jae Youl Cho

Summary: The study found that Tunisian Olea europaea leaf ethanol extract has anti-inflammatory and anti-arthritic effects, reducing inflammation and alleviating symptoms of rheumatoid arthritis. The extract contains various active compounds such as oleuropein and flavonoids, showing significant therapeutic potential.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Oncology

Effect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer The REACT Randomized Clinical Trial

R. Charles Coombes, Holly Tovey, Lucy Kilburn, Janine Mansi, Carlo Palmieri, John Bartlett, Jonathan Hicks, Andreas Makris, Abigail Evans, Sibylle Loibl, Carsten Denkert, Elisabeth Murray, Robert Grieve, Robert Coleman, Annabel Borley, Marcus Schmidt, Beate Rautenberg, Catarina Alisa Kunze, Uwe Rhein, Keyur Mehta, Kelly Mousa, Tessa Dibble, Xiao Lou Lu, Gunter von Minckwitz, Judith M. Bliss

Summary: The Randomized European Celecoxib Trial (REACT) evaluated the role of Celecoxib as an addition to conventional therapy for women with ERBB2-negative primary breast cancer. The study did not find evidence of a disease-free survival benefit for patients receiving 2 years of Celecoxib treatment compared to placebo. Longer-term treatment or higher doses of Celecoxib may need to be explored in further studies to determine potential benefits.

JAMA ONCOLOGY (2021)

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Article Veterinary Sciences

Clodronate disodium is neither cytotoxic nor cytoprotective to normal and recombinant equine interleukin-1β-treated joint tissues in vitro

Fernando B. Vergara-Hernandez, Char L. Panek, Brian D. Nielsen, Cara Robison, Aimee C. Colbath

Summary: This study investigates the effects of clodronate disodium (CLO) on equine joint tissues. The results show that CLO does not have cytotoxic or cytoprotective effects on chondrocytes, synoviocytes, or explants in culture, both in normal and IL-1 beta-stimulated conditions. Therefore, this study does not support the use of CLO as an anti-inflammatory treatment, and further research is needed to confirm its anti-inflammatory effects on joint tissues.

VETERINARY SURGERY (2023)

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Effects of a casein hydrolysate prepared from Aspergillus oryzae protease on adjuvant arthritis in rats

Journal

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Publisher

TAYLOR & FRANCIS LTD

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Antioxidant Activity of Novel Casein-Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells

Purification and Characterization of Aspartic Protease Produced from Aspergillus oryzae DRDFS13 MN726447 under Solid-State Fermentation

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Effects of a casein hydrolysate prepared from Aspergillus oryzae protease on adjuvant arthritis in rats

Journal

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Publisher

TAYLOR & FRANCIS LTD

Keywords

Categories

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Authors

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Antioxidant Activity of Novel Casein-Derived Peptides with Microbial Proteases as Characterized via Keap1-Nrf2 Pathway in HepG2 Cells

Purification and Characterization of Aspartic Protease Produced from Aspergillus oryzae DRDFS13 MN726447 under Solid-State Fermentation

Tunisian Olea europaea L. leaf extract suppresses Freund's complete adjuvant-induced rheumatoid arthritis and lipopolysaccharide-induced inflammatory responses

Effect of Celecoxib vs Placebo as Adjuvant Therapy on Disease-Free Survival Among Patients With Breast Cancer The REACT Randomized Clinical Trial

Clodronate disodium is neither cytotoxic nor cytoprotective to normal and recombinant equine interleukin-1β-treated joint tissues in vitro

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