Review
Engineering, Electrical & Electronic
Yusra Obeidat
Summary: Studies have shown a correlation between volatile acetone in breath and ketone bodies in blood, making breath analysis an attractive method for diagnosing diabetes. There is a need for affordable, easy to use, and accurate monitoring devices to help individuals with diabetes.
IEEE SENSORS JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Sarah Fruehwirth, Sandra Egger, Thomas Flecker, Miriam Ressler, Nesrin Firat, Marc Pignitter
Summary: The study found three different epoxidized triglycerides in margarine, which could potentially be used as new indicators for lipid oxidation. Acetone was identified for the first time as a lipid oxidation product in stored margarine and may serve as a new indicator for lipid oxidation.
Article
Medicine, General & Internal
Renelle Myers, Dorota M. Ruszkiewicz, Austin Meister, Crista Bartolomeu, Sukhinder Atkar-Khattra, C. L. Paul Thomas, Stephen Lam
Summary: This study aimed to develop a point-of-care breath test for detecting infected individuals with mild symptoms by identifying volatile organic compounds (VOCs) common to different variants of the SARS-CoV-2 virus. The results showed that VOCs in exhaled breath could distinguish active infection from recovery/convalescence period with high accuracy and sensitivity.
Article
Multidisciplinary Sciences
Angelika Skarysz, Dahlia Salman, Michael Eddleston, Martin Sykora, Eugenie Hunsicker, William H. Nailon, Kareen Darnley, Duncan B. McLaren, C. L. Paul Thomas, Andrea Soltoggio
Summary: Using machine learning-based analysis of GC-MS data can improve the efficiency and accuracy of VOC detection, reduce time and cost, and facilitate the large-scale deployment of breath-based diagnosis.
Article
Chemistry, Multidisciplinary
Antonella Maria Aresta, Nicoletta De Vietro, Arcangelo Picciariello, Maria Teresa Rotelli, Donato Francesco Altomare, Agnese Dezi, Gennaro Martines, Alessia Di Gilio, Jolanda Palmisani, Gianluigi De Gennaro, Carlo Zambonin
Summary: This paper presents a new protocol using SPME-GC-MS to monitor changes in endogenous VOCs released by resected colonic tissues. The VOCs from breath samples of patients were analyzed and compared with tissue samples to find a possible correlation between exhaled methylbenzene and benzaldehyde levels and the presence of colonic adenomatous polypoid lesions.
APPLIED SCIENCES-BASEL
(2023)
Article
Biochemical Research Methods
Dianlong Ge, Jijuan Zhou, Yajing Chu, Yan Lu, Xue Zou, Lei Xia, Yawei Liu, Chaoqun Huang, Chengyin Shen, Liwei Zhang, Huanzhong Wang, Yannan Chu
Summary: This study investigated the change characteristics of volatile organic compounds (VOCs) in breaths before and after gargling in healthy subjects and esophageal cancer patients using glass bottle sampling and solid-phase microextraction gas chromatography-mass spectrometry (SPME-GC-MS) technique. The results showed that the levels of certain VOCs decreased after gargling in both healthy individuals and esophageal cancer patients. These substances have been previously reported as breath biomarkers in various diseases. The study suggests that expiratory VOCs from the oral cavity should be considered in breath biomarker research, and gargle pretreatment could eliminate interference from oral cavity VOCs, benefiting breath biomarker investigation.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Engineering, Electrical & Electronic
Sara Boumali, Mohamed Taoufik Benhabiles, Ahmed Bouziane, Fouad Kerrour, Khalifa Aguir
Summary: This study successfully developed an electronic nose for non-invasive blood glucose monitoring, utilizing homemade gas sensors exposed to acetone and ethanol. Through feature extraction, selection, and classification, the system achieved 100% accuracy in estimating gas concentrations with a root mean square error of 0.2236 and 0.6639 for acetone and ethanol, respectively.
SEMICONDUCTOR SCIENCE AND TECHNOLOGY
(2021)
Article
Biochemical Research Methods
Kajsa Roslund, Markku Lehto, Pirkko Pussinen, Markus Metsala
Summary: This study measured the composition of VOCs in the morning breath of 30 healthy individuals before and after tooth brushing. They identified 35 VOCs that significantly decreased in breath after tooth brushing, indicating their microbial origin. Moreover, they compared the concentrations of these VOCs to their odor thresholds and found several compounds, including volatile sulfur compounds, that could contribute to breath odor.
JOURNAL OF BREATH RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Elina M. Gashimova, Azamat Z. Temerdashev, Dmitry V. Perunov, Vladimir A. Porkhanov, Igor S. Polyakov, Ekaterina V. Dmitrieva
Summary: Lung cancer is a major cause of death worldwide, and early diagnosis is difficult. In this study, the variability of exhaled breath samples among patients with lung cancer and other types of cancer was investigated. Two classification models were created to separate lung cancer patients from patients with cancer in other locations and to classify different types of cancer. The models showed moderate sensitivity and specificity in distinguishing lung cancer from other types of cancer, but poor accuracy in classifying different types of cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Y. Lan Pham, Olaf Holz, Jonathan Beauchamp
Summary: The first and most crucial step in breath research is adequate sampling, which plays a pivotal role in quality assurance of breath datasets. This study investigated emissions and uptake by three interface components, namely a silicon facemask, a reusable 3D-printed mouthpiece adapter, and a pulmonary function test filter compatible with the commercial Respiration Collector for In-Vitro Analysis (ReCIVA) breath sampling device. The filter exhibited the lowest overall emissions compared to the mask or adapter, which both had equivalently high emissions (albeit for different compounds). Treatment of the materials reduced the total VOC emissions by 62% in the mask, 89% in the filter and 99% in the adapter. Uptakes of compounds were lowest for the adapter and most pronounced in the mask. Knowledge of emissions and/or uptake by sampling components is key to reducing the likelihood of erroneous data interpretation, ultimately expediting progress in the field of breath test development.
JOURNAL OF BREATH RESEARCH
(2023)
Article
Optics
Xin Wei, Qingyuan Li, Yinghua Wu, Jing Li, Guangkuo Zhang, Meixiu Sun, Yingxin Li
Summary: This study developed a CRDS-based breath isoprene analysis method and found that the concentration of isoprene is significantly higher in healthy individuals compared to lung cancer patients and patients with benign lung lesions. The concentration of isoprene is meaningful for the diagnosis of lung cancer.
JOURNAL OF INNOVATIVE OPTICAL HEALTH SCIENCES
(2022)
Article
Medical Laboratory Technology
Luciana Fontes de Oliveira, Celia Mallafre-Muro, Jordi Giner, Lidia Perea, Oriol Sibila, Antonio Pardo, Santiago Marco
Summary: This study demonstrates that breath sample analysis can effectively differentiate between control, bronchiectasis, and bronchiectasis with Pseudomonas Aeruginosa infection samples.
CLINICA CHIMICA ACTA
(2022)
Article
Cell Biology
Mihai Brebu, Violeta Elena Simion, Viorel Andronie, Aylen Lisset Jaimes-Mogollon, Kelvin de Jesus Beleno-Saenz, Florina Ionescu, Tesfalem Geremariam Welearegay, Raluca Suschinel, Jose Bruno de Lema, Radu Ionescu
Summary: This study analyzed the volatile organic compounds (VOCs) emitted through breath, feces, and skin of cows diagnosed with Bovine tuberculosis (bTB) and identified potential VOC biomarkers for bTB screening. Gas chromatography coupled to mass spectrometry revealed 80 breath VOCs, 200 feces VOCs, and 80 skin VOCs. Statistical analysis identified 3 tentative breath VOC biomarkers, 9 tentative feces VOC biomarkers, and 3 tentative skin VOC biomarkers for bTB. The possible pathways of these volatile biomarkers are discussed.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Spectroscopy
Li Qing-yuan, Li Jing, Wei Xin, Sun Mei-xiu
Summary: This study presents a breath isoprene analyzer based on CRDS technology. The experimental results demonstrate that the breath isoprene analyzer has high sensitivity, good repeatability and stability, near real-time response, and good linearity.
SPECTROSCOPY AND SPECTRAL ANALYSIS
(2021)
Article
Biochemical Research Methods
Konstantin Tartakovsky, Shahar Geller, Shmuel Rozenfeld, Harel Hershtik, Regina Sinelnikov
Summary: This study demonstrates the adverse effects of water in exhaled breath samples on the accuracy of breath biomarker analysis when using gas chromatography. The presence of water significantly modifies the retention times and peak areas of compounds. A two-step approach is introduced to tackle this issue, which includes thorough desorption and secondary analysis of the same tube. This study highlights the importance of proper sample pretreatment and analysis for reliable and accurate results.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Physics, Applied
Chuji Wang, Zhiyong Gong, Yong-Le Pan, Gorden Videen
APPLIED PHYSICS LETTERS
(2016)
Article
Instruments & Instrumentation
Zhiyong Gong, Yong-Le Pan, Chuji Wang
REVIEW OF SCIENTIFIC INSTRUMENTS
(2016)
Article
Engineering, Biomedical
Xiaoxi Dong, Tianjun Liu, Han Wang, Jichun Yang, Zhuying Chen, Yong Hu, Yingxin Li
LASERS IN MEDICAL SCIENCE
(2017)
Article
Optics
Zhiyong Gong, Yong-Le Pan, Chuji Wang
Article
Chemistry, Analytical
Zhiyong Gong, Yong-Le Pan, Gorden Videen, Chuji Wang
ANALYTICA CHIMICA ACTA
(2018)
Review
Optics
Zhiyong Gong, Yong-Le Pan, Gorden Videen, Chuji Wang
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2018)
Article
Instruments & Instrumentation
Zhiyong Gong, Yong-Le Pan, Gorden Videen, Chuji Wang
APPLIED SPECTROSCOPY
(2019)
Article
Environmental Sciences
Wenhua Yu, Dian Caturini Sulistyoningrum, Danijela Gasevic, Rongbin Xu, Madarina Julia, Indah Kartika Murni, Zhuying Chen, Peng Lu, Yuming Guo, Shanshan Li
ENVIRONMENTAL POLLUTION
(2020)
Article
Clinical Neurology
Zhuying Chen, David B. Grayden, Anthony N. Burkitt, Udaya Seneviratne, Wendyl J. D'Souza, Chris French, Philippa J. Karoly, Katrina Dell, Kent Leyde, Mark J. Cook, Matias I. Maturana
Summary: The study found that high-frequency activity (HFA) and epileptiform spikes, used as bio-markers for epilepsy, exhibit high variability, especially after electrode implantation. Both HFA and spike rates show strong circadian rhythms and correlations with seizures, but these correlations are patient-specific.
Article
Clinical Neurology
Zhuying Chen, Matias I. Maturana, Anthony N. Burkitt, Mark J. Cook, David B. Grayden
Summary: HFOs have been enthusiastically studied by the epilepsy community for the past 20 years, showing promise in delineating epileptogenic brain areas and predicting seizures. Despite advancements in research using automatic detection and prediction strategies, there are still significant obstacles hindering the clinical application of HFOs as biomarkers. Collaboration and further research are needed to address these challenges.
Article
Environmental Sciences
Wenhua Yu, Rongbin Xu, Tingting Ye, Chunlei Han, Zhuying Chen, Jiangning Song, Shanshan Li, Yuming Guo
Summary: In Italy during the COVID-19 pandemic in 2020, cold temperatures were found to have a stronger impact on all-cause and non-COVID-19 mortality compared to the period before the pandemic (2015-2019), while there was no significant change in the effects of heat on mortality risk.
Article
Clinical Neurology
Zhuying Chen, Wenhua Yu, Rongbin Xu, Philippa J. Karoly, Matias Maturana, Daniel E. Payne, Lyra Li, Ewan S. Nurse, Dean R. Freestone, Shanshan Li, Anthony N. Burkitt, Mark J. Cook, Yuming Guo, David B. Grayden
Summary: The study found that daily exposure to elevated CO concentrations may be associated with an increased risk of epileptic seizures, especially for subclinical seizures. Female participants had a significantly increased risk of seizures when exposed to elevated CO and NO2.
Article
Clinical Neurology
Zhuying Chen, Matias I. Maturana, Anthony N. Burkitt, Mark J. Cook, David B. Grayden
Summary: This study explores the potential value of high-frequency activity (HFA) in seizure forecasting. Using HFA rates and phases as features, the study demonstrates that seizure forecasting based on HFA can outperform chance in most patients. Combining rate and phase information further improves the forecasting performance. These findings provide a proof of concept for incorporating HFA into future seizure forecasting algorithms.
Article
Optics
Haifa Alali, Zhiyong Gong, Gorden Videen, Yong-Le Pan, Olga Munoz, Chuji Wang
JOURNAL OF QUANTITATIVE SPECTROSCOPY & RADIATIVE TRANSFER
(2020)
Article
Chemistry, Physical
Zhiyong Gong, Yong-Le Pan, Gorden Videen, Chuji Wang
CHEMICAL PHYSICS LETTERS
(2017)