Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 36, Issue 2, Pages 205-214Publisher
SPRINGER
DOI: 10.1007/s00449-012-0776-3
Keywords
Biocomposite; Polycaprolactone; Collagen
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In this work, we fabricated highly aligned electrospun poly(epsilon-caprolactone)(PCL)/collagen biocomposites, which were consisted of multi-layered structure. The aligned directions of the composites were controlled with two rotating collectors, and various weight fractions (1, 2, 3 wt%) of collagen were embedded between the mat of PCL microfibers to improve the mechanical property and biological activities of osteoblast-like cells (MG63). The PCL/collagen biocomposite showed nine times of increment in mechanical strength of random PCL/collagen composite. An increase in collagen content in the biocomposites displayed significant increase of mechanical properties, hydrophilic property, water-absorption ability, and even cell viability of osteoblast-like cells (MG63).
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