Journal
BIOPROCESS AND BIOSYSTEMS ENGINEERING
Volume 33, Issue 8, Pages 911-920Publisher
SPRINGER
DOI: 10.1007/s00449-010-0414-x
Keywords
Redox potential; Succinic acid; Actinobacillus succinogenes NJ113; NADH/NAD(+); Metabolic flux
Funding
- 973 Program of china [2009CB724701]
- National Natural Science Foundation of China [20606017]
- Qing Lan Project of Jiangsu province
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The effects of redox potential used as a control parameter on the process of succinic acid production in batch cultures of Actinobacillus succinogenes NJ113 have been investigated. In batch fermentation, cell growth and metabolite distribution were changed with redox potential levels in the range of -100 to -450 mV. From the results, the ORP level of -350 mV was preferable, which resulted in high succinic acid yield (1.28 mol mol(-1)), high succinic acid productivity (1.18 g L-1 h(-1)) and high mole ratio of succinic acid to acetic acid (2.02). The mechanism of redox potential regulation was discussed by metabolic flux analysis and the ratio of NADH/NAD(+). We expected that redox potential can be used as a valuable parameter to monitor and control much more anaerobic fermentation production.
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