Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging-what we know and what we need to learn

Fluorescent Ligand for Human Progesterone Receptor Imaging in Live Cells

(2013) Roy Weinstain et al.   BIOCONJUGATE CHEMISTRY

One “Click” to Access Push-Triazole-Pull Fluorophores Incorporating a Pyrimidine Moiety: Structure-Photophysical Properties Relationships

(2013) Anne-Sophie Cornec et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Aromatic Sulfonyl Fluorides Covalently Kinetically Stabilize Transthyretin to Prevent Amyloidogenesis while Affording a Fluorescent Conjugate

(2013) Neil P. Grimster et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Solvatochromic Fluorescence of Biaryl Pyrimidine Nucleosides

(2013) Guillaume Mata et al.   ORGANIC LETTERS

JLigand: a graphical tool for theCCP4 template-restraint library

(2012) Andrey A. Lebedev et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Development of Protein-Labeling Probes with a Redesigned Fluorogenic Switch Based on Intramolecular Association for No-Wash Live-Cell Imaging

(2012) Yuichiro Hori et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Decoupling Fluorescence and Photochromism in Bifunctional Azo Derivatives for Bulk Emissive Structures

(2012) Aurélie Jacquart et al.   CHEMISTRY-A EUROPEAN JOURNAL

Fluorophore Targeting to Cellular Proteins via Enzyme-Mediated Azide Ligation and Strain-Promoted Cycloaddition

(2012) Jennifer Z. Yao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

No-Wash Protein Labeling with Designed Fluorogenic Probes and Application to Real-Time Pulse-Chase Analysis

(2012) Shin Mizukami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minimalist Probes for Studying Protein Dynamics: Thioamide Quenching of Selectively Excitable Fluorescent Amino Acids

(2012) Jacob M. Goldberg et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Second-Generation Covalent TMP-Tag for Live Cell Imaging

(2012) Zhixing Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Reaction-based small-molecule fluorescent probes for chemoselective bioimaging

(2012) Jefferson Chan et al.   Nature Chemistry

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enzymatic activation of nitro-aryl fluorogens in live bacterial cells for enzymatic turnover-activated localization microscopy

(2012) Marissa K. Lee et al.   Chemical Science

Chemical Tags for Labeling Proteins Inside Living Cells

(2011) Chaoran Jing et al.   ACCOUNTS OF CHEMICAL RESEARCH

Fluorescein Angiography

(2011) Michael F. Marmor   ARCHIVES OF OPHTHALMOLOGY

Development of SNAP-Tag Fluorogenic Probes for Wash-Free Fluorescence Imaging

(2011) Xiaoli Sun et al.   CHEMBIOCHEM

Chemical tags: Applications in live cell fluorescence imaging

(2011) Richard Wombacher et al.   Journal of Biophotonics

Push−PullAminobithiophenes — Highly Fluorescent Stable Fluorophores

(2011) Yanmei Dong et al.   ORGANIC LETTERS

Multicolor Protein Labeling in Living Cells Using Mutant β-Lactamase-Tag Technology

(2010) Shuji Watanabe et al.   BIOCONJUGATE CHEMISTRY

A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin

(2010) Sungwook Choi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses

(2010) Stephen Connelly et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Nobel lecture: constructing and exploiting the fluorescent protein paintbox

(2010) Roger Y. Tsien   Integrative Biology

Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: Implications to tetramer stability and ligand-binding

(2010) Daniela B.B. Trivella et al.   JOURNAL OF STRUCTURAL BIOLOGY

The binding of synthetic triiodo l-thyronine analogs to human transthyretin: Molecular basis of cooperative and non-cooperative ligand recognition

(2010) Daniela B.B. Trivella et al.   JOURNAL OF STRUCTURAL BIOLOGY

A Substructure Combination Strategy To Create Potent and Selective Transthyretin Kinetic Stabilizers That Prevent Amyloidogenesis and Cytotoxicity

(2010) Sungwook Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Stilbene That Binds Selectively to Transthyretin in Cells and Remains Dark until It Undergoes a Chemoselective Reaction To Create a Bright Blue Fluorescent Conjugate

(2010) Sungwook Choi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Superresolution Imaging of Targeted Proteins in Fixed and Living Cells Using Photoactivatable Organic Fluorophores

(2010) Hsiao-lu D. Lee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma

(2010) Sungwook Choi et al.   Nature Chemical Biology

Modulation of intramolecular heterodimer-induced fluorescence quenching of tricarbocyanine dye for the development of fluorescent sensor

(2010) Tomoya Hirano et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Monitoring Biophysical Properties of Lipid Membranes by Environment-Sensitive Fluorescent Probes

(2009) Alexander P. Demchenko et al.   BIOPHYSICAL JOURNAL

Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies†

(2009) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Azido Push−Pull Fluorogens Photoactivate to Produce Bright Fluorescent Labels†

(2009) Samuel J. Lord et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Photoactive Yellow Protein-Based Protein Labeling System with Turn-On Fluorescence Intensity

(2009) Yuichiro Hori et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Covalent Protein Labeling Based on Noncatalytic β-Lactamase and a Designed FRET Substrate

(2009) Shin Mizukami et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Improved push-pull-push E-Bodipy fluorophores for two-photon cell-imaging

(2009) Pascal Didier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Monitoring protein interactions and dynamics with solvatochromic fluorophores

(2009) Galen S. Loving et al.   TRENDS IN BIOTECHNOLOGY

Bright Ideas for Chemical Biology

(2008) Luke D. Lavis et al.   ACS Chemical Biology

Fluorescent Labeling of Biomolecules with Organic Probes

(2008) M. Sameiro T. Gonçalves   CHEMICAL REVIEWS

DCDHF Fluorophores for Single-Molecule Imaging in Cells

(2008) Samuel J. Lord et al.   CHEMPHYSCHEM

Toward Optimization of the Linker Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies†

(2008) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cy3-Cy5 Covalent Heterodimers for Single-Molecule Photoswitching

(2008) Nicholas R. Conley et al.   JOURNAL OF PHYSICAL CHEMISTRY B

A Versatile Amino Acid Analogue of the Solvatochromic Fluorophore 4-N,N-Dimethylamino-1,8-naphthalimide: A Powerful Tool for the Study of Dynamic Protein Interactions

(2008) Galen Loving et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Photoactivatable Push−Pull Fluorophore for Single-Molecule Imaging in Live Cells

(2008) Samuel J. Lord et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent probes for super-resolution imaging in living cells

(2008) Marta Fernández-Suárez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biochemical and Structural Evaluation of Highly Selective 2-Arylbenzoxazole-Based Transthyretin Amyloidogenesis Inhibitors

(2007) Steven M. Johnson et al.   JOURNAL OF MEDICINAL CHEMISTRY