Implications of protein structure instability: From physiological to pathological secondary structure

Amyloid-β as a Modulator of Synaptic Plasticity

(2017) Mordhwaj S. Parihar et al.   JOURNAL OF ALZHEIMERS DISEASE

Oxidative Balance in Alzheimer's Disease: Relationship to APOE, Braak Tangle Stage, and the Concentrations of Soluble and Insoluble Amyloid-β

(2017) Hannah Tayler et al.   JOURNAL OF ALZHEIMERS DISEASE

Fibrillar Amyloid-  Peptides Activate Microglia via TLR2: Implications for Alzheimer's Disease

(2014) M. Jana et al.   JOURNAL OF IMMUNOLOGY

Hydrophobicity and Conformational Change as Mechanistic Determinants for Nonspecific Modulators of Amyloid β Self-Assembly

(2011) Axel Abelein et al.   BIOCHEMISTRY

The Core of Ure2p Prion Fibrils Is Formed by the N-Terminal Segment in a Parallel Cross-β Structure: Evidence from Solid-State NMR

(2011) Dmitry S. Kryndushkin et al.   JOURNAL OF MOLECULAR BIOLOGY

α-Synuclein occurs physiologically as a helically folded tetramer that resists aggregation

(2011) Tim Bartels et al.   NATURE

α-synuclein gets a new look

(2011) Darran Yates   NATURE REVIEWS NEUROSCIENCE

The extracellular chaperone clusterin sequesters oligomeric forms of the amyloid-β1−40 peptide

(2011) Priyanka Narayan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Experimental free energy surfaces reveal the mechanisms of maintenance of protein solubility

(2011) A. De Simone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ Accelerates the Spatiotemporal Progression of Tau Pathology and Augments Tau Amyloidosis in an Alzheimer Mouse Model

(2010) David E. Hurtado et al.   AMERICAN JOURNAL OF PATHOLOGY

The Revitalized Tau Hypothesis on Alzheimer's Disease

(2010) Ricardo B. Maccioni et al.   ARCHIVES OF MEDICAL RESEARCH

Suppression of IAPP fibrillation at anionic lipid membranes via IAPP-derived amyloid inhibitors and insulin

(2010) Daniel Sellin et al.   BIOPHYSICAL CHEMISTRY

Beta Amyloid Aggregation Inhibitors: Small Molecules as Candidate Drugs for Therapy of Alzheimers Disease

(2010) F. Re et al.   CURRENT MEDICINAL CHEMISTRY

Gelsolin as therapeutic target in Alzheimer's disease

(2010) Eva Carro   EXPERT OPINION ON THERAPEUTIC TARGETS

Lipid rafts are primary mediators of amyloid oxidative attack on plasma membrane

(2010) Mariagioia Zampagni et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Clarifying the influence of core amino acid hydrophobicity, secondary structure propensity, and molecular volume on amyloid-β 16–22 self-assembly

(2010) F. Timur Senguen et al.   Molecular BioSystems

Alzheimer's disease: strategies for disease modification

(2010) Martin Citron   NATURE REVIEWS DRUG DISCOVERY

Ellagic acid promotes Aβ42 fibrillization and inhibits Aβ42-induced neurotoxicity

(2009) Ying Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Characterization of Hydrophobic Residue Requirements for α-Synuclein Fibrillization

(2009) Elisa A. Waxman et al.   BIOCHEMISTRY

Clusterin: A forgotten player in Alzheimer's disease

(2009) Tapio Nuutinen et al.   BRAIN RESEARCH REVIEWS

Zn(II)- and Cu(II)-induced non-fibrillar aggregates of amyloid-β (1-42) peptide are transformed to amyloid fibrils, both spontaneously and under the influence of metal chelators

(2009) Vello Tõugu et al.   JOURNAL OF NEUROCHEMISTRY

Observation of β-Sheet Aggregation in a Gas-Phase Tau-Peptide Dimer

(2009) Timothy D. Vaden et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

α-Synuclein and neuronal cell death

(2009) Mark R Cookson   Molecular Neurodegeneration

Amyloids in bacterial inclusion bodies

(2009) Natalia S. de Groot et al.   TRENDS IN BIOCHEMICAL SCIENCES

Design, synthesis, and biophysical properties of a helical Aβ1–42 analog: Inhibition of fibrillogenesis and cytotoxicity

(2008) Katsumi Matsuzaki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Preventing β-amyloid fibrillization and deposition: β-sheet breakers and pathological chaperone inhibitors

(2008) Thomas Wisniewski et al.   BMC NEUROSCIENCE

Transthyretin binding to A-Beta peptide - Impact on A-Beta fibrillogenesis and toxicity

(2008) R. Costa et al.   FEBS LETTERS

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Amyloid of Rnq1p, the basis of the [PIN+] prion, has a parallel in-register  -sheet structure

(2008) R. B. Wickner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level

(2008) Massimo Sandal et al.   PLOS BIOLOGY