Article
Multidisciplinary Sciences
Shantanu Gupta, Pritam Kumar Panda, Ronaldo F. Hashimoto, Shailesh Kumar Samal, Suman Mishra, Suresh Kr Verma, Yogendra Kumar Mishra, Rajeev Ahuja
Summary: Transfection of tumor suppressor miRNAs, such as miR-34a, miR-449a, and miR-16, can regulate apoptosis, senescence, and autophagy in cancer cells. However, the specific functions of miR-34a and miR-449a in autophagy and the cooperative or individual roles of these three miRNAs in the functional G1/S checkpoint signaling pathways in HeLa cells remain unknown. This study presents a synthetic Boolean network illustrating the regulatory effects of these miRNAs and demonstrates their advanced role in cervical cancer signaling pathways.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Sophie Mockly, Elisabeth Houbron, Herve Seitz
Summary: miR-34a does not meet the definition of tumor suppressor miRNAs, as it is not down-regulated in primary tumors and does not exhibit anti-tumorigenic activity. Therefore, synthetic administration of miR-34a is not efficient against solid tumors.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Oncology
Tingting Lu, Tao Han, Mingfang Zhao
Summary: miR-3168 is increased in liver cancer stem cells (CSCs) and inhibits CSC expansion by targeting p53 directly. Additionally, miR-3168 may be a predictor of survival benefits from transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma (HCC) patients. The study uncovers a novel mechanism of liver CSC regulation and provides a potential therapeutic target for liver CSCs.
Article
Oncology
Yiru Wang, Feiye Zhou, Mingzhu Li, Yumei Zhang, Na Li, Li Shao
Summary: This study found that miR-34a-5p is significantly increased in the liver tissues of diabetic mice and overexpression of miR-34a-5p promotes hepatic gluconeogenesis. The results of this study reveal the important role of miR-34a-5p in regulating hepatic gluconeogenesis and its potential as a target for the treatment of type 2 diabetes.
EXPERIMENTAL CELL RESEARCH
(2022)
Article
Cell Biology
Yu-Chieh Chen, Che-Wei Yang, Te-Fu Chan, Ammad Ahmad Farooqi, Hsun-Shuo Chang, Chia-Hung Yen, Ming-Yii Huang, Hsueh-Wei Chang
Summary: Cryptocaryone (CPC) derived from Cryptocarya plants has shown antiproliferative effects on ovarian cancer (OVCA) cells, particularly TOV-21G and SKOV3 cells. Its mechanisms of action include inducing oxidative stress, promoting mitochondrial dysfunction, triggering apoptosis, and causing DNA damage.
Article
Medicine, Research & Experimental
Nastaran Injinari, Zeinab Amini-Farsani, Mahtab Yadollahi-Farsani, Hossein Teimori
Summary: miR-34a and miR-520h are implicated in the apoptosis pathways, with decreased expression in cancer tissues and VPA inducing apoptosis and affecting their expression. VPA can be a possible option in breast cancer research due to its impact on the regulation of miRNAs and HDAC1.
Article
Neurosciences
Yi-Jun Li, Qing-Wen Xu, Cong-Hui Xu, Wei-Ming Li
Summary: In this study, it was found that mesenchymal stem cells (MSC) improved intestinal ischemia/reperfusion (I/R) injury by secreting exosomal miR-34a-5p and through METTL3/IGF2BP3-mediated pre-miR-34A m(6)A modification.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Fangzi Ke, Hongyun Wang, Jiaqing Geng, Xiaoqi Jing, Fang Fang, Chengzhi Fang, Bing-hong Zhang
Summary: Hypoxic-ischemic brain damage (HIBD) is a major cause of infant mortality and neurological disturbances, leading to significant pressure on families and society. Previous studies have shown that neuro-inflammation is involved in the development of HIBD. This study identified that miR-155 plays a crucial role in HIBD by promoting inflammation and apoptosis through targeting SIRT1.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Fu-Yong Li, Ting-Yong Fan, Hao Zhang, Yu-Min Sun
Summary: In liver cancer, the expression levels of miR-34a and MPP2 were found to be lower than normal tissues, and miR-34a demethylation can increase the expression level of MPP2 and promote apoptosis of liver cancer cells. This indicates that miR-34a demethylation may be a potential method for liver cancer treatment.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Genetics & Heredity
Yongxin Li, Yan Tong, Jiaqi Liu, Jianlin Lou
Summary: DNA is crucial for organism development and function. MiRNA, a type of non-coding RNA, may play an important role in the DNA damage response by influencing processes like cell cycle, DNA repair, and apoptosis, thereby impacting genomic stability and tumorigenesis.
FRONTIERS IN GENETICS
(2022)
Article
Cell Biology
Zhiqi Zhang, Haitao Yu, Wenyan Yao, Na Zhu, Ran Miao, Zhiquan Liu, Xuwei Song, Chunhua Xue, Cheng Cai, Ming Cheng, Ke Lin, Dachuan Qi
Summary: This study reveals that RRP9 plays a critical role in inducing gemcitabine chemoresistance in pancreatic cancer through the activation of the IGF2BP1/AKT signaling pathway.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Agriculture, Dairy & Animal Science
Shunshuan Han, Xiyu Zhao, Yao Zhang, Felix Kwame Amevor, Bo Tan, Mengen Ma, Houyang Kang, Jianping Wang, Qing Zhu, Huadong Yin, Can Cui
Summary: This study reveals that miR-34a-5p regulates the autophagy and apoptosis of chicken granulosa cells by targeting LEF1 to mediate the Hippo-YAP signaling pathway.
Article
Cell Biology
Mattia Pavani, Elena Chiroli, Camilla Cancrini, Fridolin Gross, Paolo Bonaiuti, Stefano Villa, Fabio Giavazzi, Vittoria Matafora, Angela Bachi, Luca L. Fava, Tiziana Lischetti, Andrea Ciliberto
Summary: Drugs targeting microtubules use the mitotic checkpoint to stop cell proliferation. Prolonged mitotic arrest caused by these drugs leads to a G1 arrest. After treating G1-arrested human cells with nocodazole and observing them for several weeks, it is found that a small fraction of cells escapes the arrest and resumes proliferation. This escape is associated with reduced DNA damage, p21 activation, and increased levels of anti-apoptotic protein Triap1.
Article
Biochemistry & Molecular Biology
Rui Bian, Wei Dang, Xiaoling Song, Liguo Liu, Chengkai Jiang, Yang Yang, Yongsheng Li, Lin Li, Xuechuan Li, Yunping Hu, Runfa Bao, Yingbin Liu
Summary: RACGAP1 is highly expressed in gallbladder cancer, promoting tumor cell proliferation and survival, and playing a role in DNA repair through binding with LIG3, ultimately reducing apoptosis and facilitating cell growth.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Cen Zhao, Dawei Yang, Yuchen Ye, Zhenzhong Chen, Tifan Sun, Jiawei Zhao, Kai Zhao, Na Lu
Summary: This study demonstrated that LT-171-861 inhibits proliferation and induces apoptosis in multiple myeloma cells by promoting DNA damage repair pathway and impeding homologous recombination. The inhibition of Pim2 kinase activity by LT-171-861 leads to DNA damage and cell apoptosis, and the combination with PARP inhibitor Olaparib enhances its anti-tumor effect.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Chun-Hong Zhou, Xiao-Peng Zhang, Feng Liu, Wei Wang
SCIENTIFIC REPORTS
(2015)
Article
Multidisciplinary Sciences
Xinyu Tian, Bo Huang, Xiao-Peng Zhang, Mingyang Lu, Feng Liu, Jose N. Onuchic, Wei Wang
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Article
Biophysics
Xiao-Peng Zhang, Feng Liu, Wei Wang
BIOPHYSICAL JOURNAL
(2012)
Article
Multidisciplinary Sciences
Xiao-Peng Zhang, Feng Liu, Wei Wang
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2014)
Article
Multidisciplinary Sciences
Xiao-Jun Tian, Feng Liu, Xiao-Peng Zhang, Jun Li, Wei Wang
Article
Multidisciplinary Sciences
Hao Li, Xiao-Peng Zhang, Feng Liu
Article
Biochemistry & Molecular Biology
Ping Wang, Han Bao, Xiao-Peng Zhang, Feng Liu, Wei Wang
Meeting Abstract
Biophysics
Xiaopeng Zhang
BIOPHYSICAL JOURNAL
(2019)
Article
Biochemistry & Molecular Biology
Cheng-Yuan Sun, Xiao-Peng Zhang, Wei Wang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Genetics & Heredity
Cheng-Yuan Sun, Xiao-Peng Zhang, Feng Liu, Wei Wang
FRONTIERS IN GENETICS
(2020)
Article
Biochemistry & Molecular Biology
Hang-Yu Wang, Xiao-Peng Zhang, Wei Wang
Summary: The study demonstrated that under aggravating hypoxia, the sequential activation of three positive feedback loops involving HIF-1 alpha and its targets SNAIL, TWIST, and miR-210 is crucial for inducing EMT. The number of positive feedback loops was found to be critical in determining the number of stable states in EMT regulation. This research highlights the significance of network topology in EMT regulation.
Article
Mathematical & Computational Biology
Xiao-Wei Ye, Xiao-Peng Zhang, Feng Liu
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2019)
Article
Physics, Fluids & Plasmas
Liu-Suo Wang, Ning-Xi Li, Jing-Jia Chen, Xiao-Peng Zhang, Feng Liu, Wei Wang
Article
Physics, Multidisciplinary
Dao-Guang Wang, Chun-Hong Zhou, Xiao-Peng Zhang