Article
Health Care Sciences & Services
Aikaterini Vraka, Vicente Bertomeu-Gonzalez, Lorenzo Facila, Jose Moreno-Arribas, Raul Alcaraz, Jose J. Rieta
Summary: This study analyzes the crucial steps of coronary sinus catheterization and left and right pulmonary veins isolation in pulmonary veins catheter ablation for atrial fibrillation. The results show that P-waves are more affected than local activation waves by the ablation process, and LPVI has the most significant impact on P-wave duration.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Physiology
Lisa A. A. Gottlieb, Lukas R. C. Dekker, Ruben Coronel
Summary: Atrial fibrillation (AF) often requires invasive treatment in the form of ablation, but incomplete ablation of the pulmonary veins (PV) can still cure AF in some patients. This suggests that an antiarrhythmic effect other than electrical isolation plays a role in preventing AF. We propose that modifying the arrhythmogenic substrate in the PV can be a new therapeutic approach for a subgroup of patients with PV reentry.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Jorge G. Quintanilla, Shlomo Shpun, Jose Jalife, David Filgueiras-Rama
Summary: Modern cardiac electrophysiology has made significant advancements in understanding the mechanisms of atrial fibrillation (AF) and the debate between randomly propagating wavelets and deterministic rotors continues. Recent research supports the feasibility of targeting and ablating AF driver regions outside of pulmonary veins. New technologies and methodologies have provided platforms for clinicians to implement novel approaches in AF ablation procedures.
CARDIOVASCULAR RESEARCH
(2021)
Article
Engineering, Biomedical
Mikael Henriksson, Alba Martin-Yebra, Monika Butkuviene, Jakob Gulddahl Rasmussen, Vaidotas Marozas, Andrius Petrenas, Aleksei Savelev, Pyotr G. Platonov, Leif Sornmo
Summary: This study introduces a model-based, statistical approach to characterize episode patterns in paroxysmal atrial fibrillation (AF), showing different fitting results for different transition types and the association of model parameters with AF episode clustering. Point process modeling provides a detailed description of AF episode patterns, contributing to a better understanding of arrhythmia progression.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Mathematics, Applied
Andres Orozco-Duque, Juan P. Ugarte, Catalina Tobon
Summary: Through computational simulations, we found that phase synchronization method performs better than other methods for detecting rotors under different fibrillatory patterns, highlighting the core of stable rotors with phase-locking maps during atrial fibrillation episodes.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2021)
Article
Cardiac & Cardiovascular Systems
Timothy R. Betts, Wilson W. Good, Lea Melki, Andreas Metzner, Andrew Grace, Atul Verma, Stephen Murray, Simon James, Tom Wong, Lucas V. A. Boersma, Daniel Steven, Arian Sultan, Sonia Busch, Petr Neuzil, Carlo de Asmundis, Justin Lee, Tamas Szili-Torok
Summary: The RECOVER AF study evaluated the performance of non-contact charge-density mapping to guide the ablation of non-PV targets in persistent AF patients. The study showed that 76% of patients were AF-free at 12 months. For patients who had only received PVI, the AF-free rate was 91%.
Article
Multidisciplinary Sciences
Ricardo Abad, Orvil Collart, Prasanth Ganesan, A. J. Rogers, Mahmood Alhusseini, Miguel Rodrigo, Sanjiv M. Narayan, Wouter-Jan Rappel
Summary: The study found that the use of algorithms to visualize spiral waves and their tip locations on curved atrial geometries is helpful for studying atrial fibrillation. Additionally, AF maps and spiral tip locations calculated between 3D anatomical shells and 2D unfolded surfaces are qualitatively and quantitatively similar.
Article
Cardiac & Cardiovascular Systems
Michelle Lycke, Maria Kyriakopoulou, Milad El Haddad, Jean-Yves Wielandts, Gabriela Hilfiker, Alexandre Almorad, Teresa Strisciuglio, Jan De Pooter, Michael Wolf, Philippe Unger, Yves Vandekerckhove, Rene Tavernier, Jean-Benoit e Polain de Waroux, Mattias Duytschaever, Sebastien Knecht
Summary: The study aimed to identify predictors for atrial fibrillation (AF) recurrence 1 year after CLOSE-guided pulmonary vein isolation (PVI) in patients with paroxysmal AF.
Article
Cardiac & Cardiovascular Systems
Xi Li, Yanhong Chen, Guanghui Chen, Chengang Deng, Chen Tang, Jinlin Zhang
Summary: This study aimed to investigate whether the combination of single-ring isolation (SRI) and superior vena cava isolation (SVCI) could improve the success rate of paroxysmal atrial fibrillation (PAF) ablation. The novel ablation strategy of SRI combined with SVCI was found to be feasible, safe, and associated with a relatively high success rate.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Bao-Oanh Nguyen, Vanessa Weberndorfer, Harry J. G. M. Crijns, Bastiaan Geelhoed, Hugo Ten Cate, Henri Spronk, Abraham Kroon, Ruben De With, Meelad Al-Jazairi, Alexander H. Maass, Yuri Blaauw, Robert G. Tieleman, Martin E. W. Hemels, Justin Luermans, Joris de Groot, Cornelis P. Allaart, Arif Elvan, Mirko De Melis, Coert Scheerder, Anton Jan van Zonneveld, Ulrich Schotten, Dominik Linz, Isabelle Van Gelder, Michiel Rienstra
Summary: This study aims to develop a new atrial fibrillation (AF) progression risk prediction model in patients with paroxysmal AF (PAF) to determine the risk and treatment targets for AF progression. The study found that markers for atrial remodeling, sex, mitral valve regurgitation, waist circumference, and biomarkers associated with coagulation, inflammation, cardiomyocyte stretch, and atherosclerosis were all associated with AF progression.
Article
Cardiac & Cardiovascular Systems
Xiangyu Li, Mingfang Li, Yongfeng Shao, Weidong Gu, Buqing Ni, Jiaxi Gu, Minglong Chen
Summary: The study aimed to determine whether mini-invasive transthoracic atrial fibrillation ablation can delay the progression of atrial fibrillation from paroxysmal to persistent. The results showed that patients who chose transthoracic atrial fibrillation ablation had a lower incidence of progression to persistent atrial fibrillation compared to patients who chose conservative therapy.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andreas Metzner, Karl-Heinz Kuck, Julian K. R. Chun
Summary: Atrial fibrillation ablation is an important treatment option for symptomatic patients, with electrical isolation of the pulmonary veins as the cornerstone. The lack of persistent isolation limits the understanding of the impact on AF suppression, necessitating the development of novel ablation systems to improve success rates.
Article
Health Care Sciences & Services
Wei-Ting Sung, Li-Wei Lo, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Fa-Po Chung, Jo-Nan Liao, Ta-Chuan Tuan, Tze-Fan Chao, Chin-Yu Lin, Ting-Yung Chang, Ling Kuo, Chih-Min Liu, Shin-Huei Liu, Wen-Han Cheng, An Khanh-Nu Ton, Chu-Yu Hsu, Chheng Chhay, Ahmed Moustafa Elimam, Ming-Jen Kuo, Pei-Heng Kao, Wei-Tso Chen, Shih-Ann Chen
Summary: The autonomic system plays a key role in the pathogenesis of paroxysmal atrial fibrillation (AF). Skin sympathetic nerve activity (SKNA) is a noninvasive tool for assessing sympathetic tone. SKNA significantly increased 1 day after ablation and returned to baseline levels 3 months after ablation.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Youzheng Dong, Zhenyu Zhai, Jihong Wang, Zhen Xia, Zirong Xia, Bo Zhu, Quanbing Dong, Qing Li, Juxiang Li
Summary: This study aimed to investigate if angiotensin receptor-neprilysin inhibitor (ARNI) can delay the progression of atrial fibrillation (AF) from paroxysmal to persistent. The results showed that compared to patients treated with angiotensin receptor blocker (ARB), patients treated with ARNI had a lower risk of AF progression. This study provides important clinical evidence for preventing the worsening of atrial fibrillation.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Xia Zhong, Huachen Jiao, Dongsheng Zhao, Jing Teng
Summary: This study investigates the association between serum uric acid levels and paroxysmal atrial fibrillation (AF) and reveals a significant correlation between elevated uric acid levels and paroxysmal AF in female patients in China.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Jose Millet, Yuriana Aguilar-Sanchez, Dmytro Kornyeyev, Maedeh Bazmi, Diego Fainstein, Julio A. Copello, Ariel L. Escobar
Summary: Ca2+ alternans (Ca-Alts) are beat-to-beat changes in the amplitude of Ca2+ transients that frequently occur during tachycardia, ischemia, or hypothermia. This alternation appears to result from variation in Ca2+ release from the sarcoplasmic reticulum (SR) in consecutive heartbeats, possibly due to changes in action potential duration, delayed recovery of RYR Ca2+ release channel (RYR2) inactivation, or incomplete Ca2+ refilling of the SR. Using fluorescence local field optical mapping (FLOM), researchers observed larger Ca-Alts in colder regions without changes in action potential duration. The findings suggest that the steep temperature dependency of Ca-Alts during tachycardia may be related to insufficient SERCA-mediated Ca2+ uptake into the SR, which can be promoted by partial pharmacologic inhibition of SERCA2a.
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Computer Science, Interdisciplinary Applications
Samuel Ruiperez-Campillo, Sergio Castrejon, Marcel Martinez, Raquel Cervigon, Olivier Meste, Jose Luis Merino, Jose Millet, Francisco Castells
Summary: The study proposed a noninvasive approach based on comparing atrial vectorcardiogram loops to differentiate between the most common forms of right and left macroreentrant atrial tachyarrhythmias. Results showed effectiveness in identifying different types of arrhythmias and predicting the existence and location of a slow conduction zone.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Correction
Physiology
Jose Millet, Yuriana Aguilar-Sanchez, Dmytro Kornyeyev, Maedeh Bazmi, Diego Fainstein, Julio A. Copello, Ariel L. Escobar
JOURNAL OF GENERAL PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Israel Griol-Barres, Sergio Milla, Antonio Cebrian, Yashar Mansoori, Jose Millet
Summary: This study presented technologies for physical implementation of qubits and quantum gates, focusing on the application of a quantum circuit based on support vector machines for classification problems. The experimental results showed promising outcomes, indicating the potential of quantum computing in detecting weak signals. However, further technological development is still required to fully leverage quantum computing capabilities.
APPLIED SCIENCES-BASEL
(2021)
Article
Electrochemistry
Josue Ferri, Raul Llinares, Izan Segarra, Antonio Cebrian, Eduardo Garcia-Breijo, Jose Millet
Summary: This paper presents a new manufacturing process for a dry ECG electrode printed on a textile substrate. The electrode is made by screen printing a conductive silver ink coated with a biocompatible carbon layer. The impedance measurements and comparison with a conventional wet electrode show promising results for the dry electrode's performance in ECG monitoring.
ELECTROCHEMISTRY COMMUNICATIONS
(2022)
Article
Biophysics
Santiago Jimenez-Serrano, Miguel Rodrigo, Conrado J. Calvo, Jose Millet, Francisco Castells
Summary: This study proposed and validated an automated method for classifying ECG recordings, and evaluated the performance of different lead systems in detecting cardiac diseases.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Biology
Francisco Castells, Samuel Ruiperez-Campillo, Izan Segarra, Raquel Cervigon, Ruben Casado-Arroyo, Jose Luis Merino, Jose Millet
Summary: The aim of this study is to propose a method to reduce the sensitivity of the estimated omnipolar electrogram (oEGM) with respect to the angle of the propagation wavefront. A novel configuration of cliques taking into account all four electrodes of a squared cell is proposed. The proposed approach successfully provided narrower loops of the electrical field described by the bipole pair with respect to the conventional approach, and improved estimation of the direction of propagation.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Engineering, Biomedical
Samuel Ruiperez-Campillo, Marina Crespo, Alvaro Tormos, Antonio Guill, Antonio Cebrian, Antonio Alberola, Jakob Heimer, Francisco J. Chorro, Jose Millet, Francisco Castells
Summary: High-density catheters combined with Orientation Independent Sensing (OIS) methods have been shown to be groundbreaking for cardiac substrate characterisation. This study aimed to assess the reliability of estimating omnipolar electrograms (oEGMs) using different configurations and interelectrode spacings. The results demonstrated that the most reliable oEGM estimations were obtained with cross-configurations and 2 mm interelectrode spacings. Estimations from triangular cliques resulted in wider electric field loops and unreliable detection of the direction of the propagation wavefront. The findings highlight the need for improved oEGM estimation techniques and offer insights for the design of new-generation HD catheters and mapping software.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2023)
Proceedings Paper
Computer Science, Interdisciplinary Applications
Santiago Jimenez-Serrano, Miguel Rodrigo, Conrado J. Calvo, Francisco CasteHs, Jose Millet
Summary: The team aimed to classify ECG records using minimal lead information and a single-lead approach. By resampling and filtering signals, extracting features based on HRV, training neural networks, and conducting cross-validation, they achieved good performance in detecting cardiac diseases. The method may be beneficial for portable or wearable ECG devices as screening tools.
2021 COMPUTING IN CARDIOLOGY (CINC)
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
W. M. Lozano, J. Arias-Mutis, C. J. Calvo, A. Bizy, L. Such-Miquel, F. J. Chorro, J. Zhao, A. Alberola, M. Zarzoso
EUROPEAN HEART JOURNAL
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. J. Calvo, A. Rodriguez, E. Almar, O. Arias, W. Lozano, A. Alberola, M. Zarzoso
EUROPEAN HEART JOURNAL
(2021)
Meeting Abstract
Cardiac & Cardiovascular Systems
C. J. Calvo, M. Zarzoso, A. Guill, A. Tormos, L. Such, A. Alberola, J. Millet, F. J. Chorro-Gasco
EUROPEAN HEART JOURNAL
(2021)