Article
Cell Biology
Milene N. O. Moritz, Paulo R. Dores-Silva, Amanda L. S. Coto, Heloisa S. Selistre-de-Araujo, Andrei Leitao, David M. Cauvi, Antonio De Maio, Serena Carra, Julio Cesar Borges
Summary: This study further investigated the interactions between hHep1 and negatively charged liposomes, as well as cellular membranes. The results showed that hHep1 can interact with liposomes formed by specific lipids and remain partially structured. Additionally, upon addition to the cell membrane, hHep1 can be incorporated by cells, and its association with HSPA9 improves the incorporation of these proteins into the lipid bilayer.
CELL STRESS & CHAPERONES
(2023)
Article
Chemistry, Multidisciplinary
Yaguang Wu
Summary: This study investigates reliability modeling and optimal preventive maintenance policies for engineering systems subject to shocks, considering two types of self-exciting mechanisms. The reliability indices are obtained through the finite Markov chain imbedding approach based on the established shock models. Two types of preventive maintenance strategies are considered according to the operation of the system under different monitoring conditions, and optimization models are established to determine the optimal preventive maintenance thresholds.
APPLIED SCIENCES-BASEL
(2022)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Review
Plant Sciences
Yeeun Kang, Kwanuk Lee, Ken Hoshikawa, Myeongyong Kang, Seonghoe Jang
Summary: The effects of climate change, such as increased global temperatures and abnormal weather events, are causing concerns for plant vegetation and crop productivity. This review focuses on the molecular processes of plants in response to heat stress, with emphasis on the classification and functions of heat shock proteins. Developing vegetable crops with enhanced thermotolerance using genetic tools is crucial to alleviate the adverse effects of heat stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Cell Biology
Antonio De Maio, Lawrence Hightower
Summary: The interaction of heat shock proteins with cellular membranes is a complex and mysterious process that serves important functions in protein insertion into lipid bilayers. HSP70 forms ion channels after membrane insertion, showing strong selectivity for negatively charged phospholipids, while other HSP have a broader specificity for lipids.
CELL STRESS & CHAPERONES
(2021)
Article
Environmental Sciences
He Huang, Min Wang, Lulu Hou, Xu Lin, Shifeng Pan, Peng Zheng, Qian Zhao
Summary: Lead is a toxic heavy metal that can damage male reproductive function. Selenium has the ability to counteract lead toxicity, and in this study, it was found that selenium can mitigate the reproductive toxicity of lead by enhancing antioxidant defense mechanisms in the spermatogonia and Leydig cells of chickens.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Chemistry, Multidisciplinary
Mengyao Yang, Xingshu Li, Gyoungmi Kim, Rui Wang, Seong-Jin Hong, Chang-Hee Lee, Juyoung Yoon
Summary: In this study, a J-aggregated nano-porphyrin called MTE was constructed through self-assembly. The nano-porphyrin has small and uniform size, effectively avoiding the side effects of phototoxicity and achieving enhanced photodynamic therapy and adjuvant mild-temperature laser interstitial thermal therapy. This research is significant for the development of multicomponent nanoplatforms and efficient low-toxicity phototherapy.
Article
Multidisciplinary Sciences
Tsukumi Miwa, Hideki Taguchi
Summary: Research has shown that IbpA down-regulates the expression of multiple heat shock proteins (Hsps) by repressing the translation of the heat shock transcription factor sigma(32), and plays a crucial role in shutting down the heat shock response. These findings reveal an unknown role of IbpA in regulating the heat shock response at the translational level.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Ahmed Barakat, Even Birkeland, Melissa D. Jorstad, Magalie El Hajj, Msafiri Marijani, Anne Doskeland, Olav Mjaavatten, Frode S. Berven, Tehmina Mustafa
Summary: This study investigated the proteomic profile of PBMCs in pulmonary tuberculosis (PTB) patients to predict treatment response. Blood samples were collected from 8 adult PTB patients in Tanzania at baseline, 2 months of treatment, and treatment completion. Proteins extracted from PBMCs were quantified and analyzed using LC-MS/MS. The results identified differentially expressed proteins involved in cellular processes, metabolic processes, binding, and catalytic activity, suggesting that proteome analysis of PBMCs can be used as a novel technique to monitor anti-tuberculosis treatment response and gain insights into PTB.
Article
Thermodynamics
Keqiang Li, Yajuan Cheng, Hongying Wang, Yangyu Guo, Zhongwei Zhang, Marc Bescond, Massahiro Nomura, Sebastian Volz, Xiaohong Zhang, Shiyun Xiong
Summary: This study investigates thermal transport in nanostructures using non-equilibrium molecular dynamics simulations and highlights the engineering of low-frequency phonon transport with the phonon resonant mechanism. The results show that surfaces can introduce anisotropic thermal transport, and resonant effects can significantly reduce the thermal conductivity of membranes. Furthermore, the resonant coupling strength can be tuned by interface vacancies.
INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER
(2022)
Review
Green & Sustainable Science & Technology
Hussein M. Maghrabie
Summary: The efficiency, availability, and reliability of thermal management in various engineering applications pose a crucial challenge for designers and engineers. The study comprehensively reviews the heat transfer characteristics and fluid flow behavior of jet impingement with recent modifications, as well as the critical methods of passive and active exciting jets. The excitation of jets causes flow topological metamorphosis and significantly impacts heat transfer enhancement.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2021)
Article
Microbiology
Felix Gruenberger, Georg Schmid, Zubeir El Ahmad, Martin Fenk, Katharina Vogl, Robert Reichelt, Winfried Hausner, Henning Urlaub, Christof Lenz, Dina Grohmann
Summary: This study investigated the transcriptomic and proteomic responses of hyperthermophilic archaea Pyrococcus furiosus to heat and cold shock stress. The results showed rapid and dynamic changes in gene and protein expression following these stress responses. The study also identified distinct short- and long-term responses at both the RNA and protein levels to cold shock. The findings contribute to our understanding of stress response mechanisms in extremophiles.
Article
Mathematics
Yaguang Wu, Qingan Qiu
Summary: This paper studies multi-state systems equipped with a protective device in shock environments, considering the self-exciting mechanism of valid and invalid shocks. By optimizing the triggering threshold of the protective device, the system reliability can be improved. Numerical results show that protective devices can significantly enhance system reliability, and incorporating the self-exciting mechanism of shocks into reliability modeling contributes to accurate reliability evaluation.
Review
Cell Biology
Willy Roque
Summary: This review examines the roles of specific heat shock proteins (HSPs), including HSP90, HSP70, and HSP47, in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Understanding the functions of these HSPs in the development of IPF can provide valuable insights for the future treatment and prevention of IPF.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Ricardo Araujo, Vincent Fernandez, Richard D. Rabbitt, Eric G. Ekdale, Miguel T. Antunes, Rui Castanhinha, Joerg Froebisch, Rui M. S. Martins
Article
Multidisciplinary Sciences
M. M. Iversen, H. Zhu, W. Zhou, C. C. Della Santina, J. P. Carey, R. D. Rabbitt
SCIENTIFIC REPORTS
(2018)
Review
Neurosciences
R. D. Rabbitt
JOURNAL OF NEUROPHYSIOLOGY
(2019)
Article
Neurosciences
Alejandro Lopez-Cruz, Aylesse Sordillo, Navin Pokala, Qiang Liu, Patrick T. McGrath, Cornelia I. Bargmann
Article
Neurosciences
Holly A. Holman, Lauren A. Poppi, Micah Frerck, Richard D. Rabbitt
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Biology
May Dobosiewicz, Qiang Liu, Cornelia I. Bargmann
Editorial Material
Neurosciences
Henrique von Gersdorff, Marta M. Iversen, Richard D. Rabbitt
JOURNAL OF PHYSIOLOGY-LONDON
(2020)
Article
Multidisciplinary Sciences
Maria C. Perez-Flores, Jeong H. Lee, Seojin Park, Xiao-Dong Zhang, Choong-Ryoul Sihn, Hannah A. Ledford, Wenying Wang, Hyo Jeong Kim, Valeriy Timofeyev, Vladimir Yarov-Yarovoy, Nipavan Chiamvimonvat, Richard D. Rabbitt, Ebenezer N. Yamoah
Article
Multidisciplinary Sciences
Holly A. Holman, Yong Wan, Richard D. Rabbitt
Article
Multidisciplinary Sciences
Richard D. Rabbitt
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Multidisciplinary Sciences
Lois Naudin, Juan Luis Jimenez Laredo, Qiang Liu, Nathalie Corson
Summary: This paper proposes a systematic approach based on multi-objective optimization for building general non-spiking models with generalization capabilities. The approach is applied on three non-spiking neurons of C. elegans to study their responses.
Article
Multidisciplinary Sciences
Jingyuan Jiang, Yifan Su, Ruilin Zhang, Haiwen Li, Louis Tao, Qiang Liu
Summary: This study identified a novel circuit of spiking neurons in C. elegans that uses digital coding for long-distance communication and temporal synchronization, which is crucial for reliable behavioral rhythm.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Jan Kubanek, Matthew Wilson, Richard D. Rabbitt, Celeste J. Armstrong, Alexander J. Farley, H. M. Arif Ullah, Alex Shcheglovitov
Summary: By studying human brain organoids, we found that ultrasound stimulation can modulate the activity of neural networks in the brain, which is important for personalized diagnosis and treatment of brain disorders.
Article
Multidisciplinary Sciences
Richard D. Rabbitt, Tamara C. Bidone
Summary: This study investigates the variation of cochlear outer hair cell (OHC) properties along the tonotopic map to optimize electromechanical power conversion. A simple model of a single isolated OHC driving a mechanical load was used for testing. Results indicate the presence of three non-dimensional ratios that optimize power conversion, which should be universal constants independent of frequency and species. These ratios act as control parameters to maximize power output by positioning the OHC operating point on the edge of a dynamic instability.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Neurosciences
Leo L. Shen, Nicholas S. Andresen, Divya A. Chari, Jacob M. Pogson, Amanda M. Lauer, Richard D. Rabbitt, John P. Carey, Felipe Santos, Bryan K. Ward
Summary: Meniere's disease is a debilitating disorder with unclear pathophysiology. This study examines the dissociation between two vestibular function tests commonly used in patients with MD and reveals the presence of otolith membrane herniation in the semicircular canals of MD ears, which is associated with abnormal caloric responses. The study also suggests the relative size of the membranous duct to the bony canal may be important in understanding the mechanisms of MD.
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2023)