Article
Chemistry, Physical
Angelina Folberth, Nico F. A. van der Vegt
Summary: This study investigates the effect of trimethylamine N-oxide (TMAO) on the pressure stability of hydrophobic contact interaction in nonpolar alpha-helices through computer simulations. The results indicate that TMAO counteracts the disruption caused by pressure destabilization by increasing the dipole moment of TMAO under solvent compression. This direct stabilization mechanism becomes ineffective without considering the dipole polarization of TMAO and is associated with nonspecific van der Waals interactions between TMAO and the nonpolar surfaces of the helices, which weaken as TMAO becomes more polarized under high pressure. The findings have implications for hydrophobic interactions under high pressure and suggest that TMAO stands out as a piezolyte among stabilizing osmolytes, potentially protecting biological assemblies formed by hydrophobic interactions under extreme pressure conditions.
JOURNAL OF CHEMICAL PHYSICS
(2022)
Article
Geosciences, Multidisciplinary
Cyril Chelle-Michou, Anders McCarthy, Jean-Francois Moyen, Peter A. Cawood, Fabio A. Capitanio
Summary: The term 'subduction' has been broadly used with weakened meanings in the scientific discourse, leading to obstacles in discussing tectonic processes. This paper discusses the impacts of using ill-defined terms on scientific discussions and proposes a new framework focusing on two parameters to summarize different end-member modes of foundering.
EARTH-SCIENCE REVIEWS
(2022)
Article
Chemistry, Multidisciplinary
Julian L. Kessler, Grace Kang, Zhao Qin, Helen Kang, Frank G. Whitby, Thomas E. Cheatham, Christopher P. Hill, Yang Li, S. Michael Yu
Summary: This study reveals that N-substituted glycines have the potential to stabilize the triple-helix structure, making them valuable for synthesizing collagen-mimetic peptides with unprecedented side chain diversity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Review
Behavioral Sciences
Gene M. Heyman
Summary: This paper discusses the non-eliminable features of addiction and the underlying basic choice processes, suggesting that addiction emerges from the interactions of normal choice processes and the behaviorally toxic effects of drugs. The analysis shows that addiction is a semi-stable state biased towards remission, with high rates of unassisted or spontaneous remission.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Meteorology & Atmospheric Sciences
Shihua Liu, Joshua-Xiouhua Fu, Zhiping Wen, Peng Zhang
Summary: In this diagnostic study, three distinctive MJO types in boreal winter are documented and their controlling mechanisms and teleconnections are investigated with a synergetic global approach. It is revealed that the diverse nature of the MJO primarily results from different tropical-extratropical interactions and associated internal atmospheric processes.
Article
Cell Biology
Wan-Qing Yu, Rachael Swanstrom, Crystal L. Sigulinsky, Richard M. Ahlquist, Sharm Knecht, Bryan W. Jones, David M. Berson, Rachel O. Wong
Summary: Neurons form converging and diverging synaptic connections with different partner types. The structural arrangements of synapses involving separate partners are still not well understood. In this study, mouse retina was used to map and compare the structural arrangements of cone bipolar cells (CBCs) synapses across different bipolar types and postsynaptic partners. The observations revealed that CBCs exhibit at least six motifs, with each CBC type using these motifs in a stereotypic pattern. The synapses between CBCs and specific partner types show a bias towards certain motifs. These findings provide insights into the diversification of synaptic output within and across CBC types.
Article
Oncology
Juntuo Zhou, Yimeng Song, Tianying Xing, Liyuan Ge, Lulin Ma, Min Lu, Lijun Zhong
Summary: The study conducted a proteomic analysis on the thrombus of ccRCC patients, revealing 251 dysregulated proteins and identifying molecular pathways and regulatory networks associated with the thrombus. Experimental validation confirmed the reliability of the proteomic analysis.
TRANSLATIONAL ONCOLOGY
(2021)
Article
Genetics & Heredity
Dan Wang, Huiyu Peng, Yuyao Hu, Xue Piao, Dianshuai Gao, Yan Sha
Summary: This study aimed to understand the molecular mechanisms of pregnancy-associated breast cancer (PABC) by analyzing the differentially expressed genes in PABC compared to non-pregnancy-associated breast cancer (NPABC) and normal breast tissue. Dysregulated genes were identified, with a focus on MAGE and CXCL family genes. The dysregulated genes were mainly associated with signal transduction and immune response, and Kyoto Encyclopedia of Genes and Genomes analysis revealed enrichment in immune-related pathways. Hub genes with differential expression in PABC versus NPABC were identified, including CD44 and BRCA1. Additionally, a cluster of eleven hub genes was found in PABC versus normal adjacent tissues, and IGF1, PTGS2, and FGF1 were shown to be significantly related to patient prognosis.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Andrei Daniel Timofte, Irina-Draga Caruntu, Adrian C. Covic, Monica Hancianu, Nona Girlescu, Mariana Bianca Chifu, Simona Eliza Giusca
Summary: Prostate cancer is a common malignancy with diverse clinical outcomes. This study investigated the relationship between renal function and different molecular subtypes of prostate adenocarcinomas. The study analyzed 72 patients with prostate cancer and associated chronic kidney disease who underwent radical prostatectomy. The results showed that the overexpression of SPINK1 was associated with higher kidney disease stages and serum creatinine levels, while TFF3 was linked to kidney function. The study also revealed associations between kidney disease stages and prognostic grade groups in different molecular subtypes, highlighting the complex interplay between kidney function and tumor behavior.
Article
Food Science & Technology
Ivana Karabegovic, Marko Malicanin, Nikola Popovic, Sandra Stamenkovic Stojanovic, Miodrag Lazic, Jelena Stanojevic, Bojana Danilovic
Summary: This study analyzed the enological potential of two indigenous yeast isolates, Hanseniaspora uvarum S-2 and Candida famata WB-1, in industrial-scale vinification of the grape variety Tamjanika. The results showed that these yeast isolates were able to complete alcoholic fermentation, reduce ethanol concentration, and enhance aroma and sensory profile of the wine. The analysis of volatile compounds indicated that the yeast strains significantly affected the relative contribution of these compounds, resulting in the differences and uniqueness of the obtained wine samples.
Article
Education & Educational Research
Zhi Quan, Lynn Grant, Darryl Hocking, Andy Connor
Summary: In recent years, mobile learning (m-learning) has gained increasing attention and popularity among educators and students worldwide. This paper argues that m-learning should be studied in terms of the mobility of devices, learners, and materials. The paper also presents empirical research on m-learning for academic English, assessing learner engagement through a combination of automatic logging, questionnaires, and interviews. The findings highlight the distinctiveness of m-learning and offer implications for its future development.
INTERACTIVE LEARNING ENVIRONMENTS
(2022)
Article
Multidisciplinary Sciences
Seungjae Lee, Yen-Chung Chen, Austin E. Gillen, J. Matthew Taliaferro, Bart Deplancke, Hongjie Li, Eric C. Lai
Summary: Most genes in higher eukaryotes express isoforms with distinct 3' untranslated regions (3' UTRs) through alternative polyadenylation (APA). This study explores the cell-type expression of 3' UTRs in over 250 adult Drosophila cell types using single nucleus RNA-sequencing data. The researchers reveal tissue-specific APA/ALE programs and dynamic 3' UTR patterns across cell lineages, providing a foundation for future investigations of alternative isoforms in this model organism.
NATURE COMMUNICATIONS
(2022)
Article
Engineering, Environmental
Yu-Ting Zhang, Wei Wei, Chen Wang, Bing-Jie Ni
Summary: This study compared the stress responses of anaerobic hydrogen-producing granular sludge to different types of microplastics (MPs) and proposed a new method using biochar to mitigate the inhibition caused by MPs. The results showed that biochar could restore hydrogen production in HPG, reduce direct contact between microbes and MPs, and increase EPS secretion, thus enhancing protection for HPG.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Christina J. Codden, Michael T. Chin
Summary: By analyzing snRNA-seq datasets of HCM patient samples, we found differentially expressed genes and distinct patterns of intercellular communication between obstructive and nonobstructive HCM, providing opportunities for personalized management of different HCM phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
PingPing Xiang, Sara Ahmadi, Alexandra Coleman, William West, Isabel Lobon, Athanasios Bikas, Inigo Landa, Ellen Marqusee, Matthew Kim, Erik K. Alexander, Theodora Pappa
Summary: This study aimed to better define the diverse patterns of benign nodule behavior and their predictors. The researchers found that the natural history of benign nodule growth is diverse, with over 80% of nodules demonstrating minimal to no growth long-term. Approximately 20% of cytologically benign nodules may exhibit a fast, continued growth pattern, which can be predicted by the 3-year growth rate pattern.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Chemistry, Physical
Jorg Rosgent, Matthew Auton
JOURNAL OF PHYSICAL CHEMISTRY B
(2016)
Article
Biochemistry & Molecular Biology
Alexander Tischer, Venkata R. Machha, Jorg Rosgen, Matthew Auton
Article
Biochemistry & Molecular Biology
Luis Marcelo F. Holthauzen, Joerg Roesgen, D. Wayne Bolen
Review
Biochemistry & Molecular Biology
Krishna Rajarathnam, Joerg Roesgen
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2014)
Article
Biochemistry & Molecular Biology
Matthew Auton, Joerg Roesgen, Mikhail Sinev, Luis Marcelo F. Holthauzen, D. Wayne Bolen
BIOPHYSICAL CHEMISTRY
(2011)
Article
Chemistry, Physical
Joerg Roesgen
JOURNAL OF PHYSICAL CHEMISTRY B
(2015)
Article
Chemistry, Multidisciplinary
Joerg Roesgen, Ruby Jackson-Atogi
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2012)
Article
Multidisciplinary Sciences
Woon Ki Lim, Jorg Rosgen, S. Walter Englander
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2009)
Article
Biochemistry & Molecular Biology
Timothy O. Street, Kristin A. Krukenberg, Joerg Rosgen, D. Wayne Bolen, David A. Agard
Article
Biochemistry & Molecular Biology
Matthew Auton, D. Wayne Bolen, Jorg Rosgen
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2008)
Article
Biophysics
Hironori Kokubo, Jorg Roesgen, D. Wayne Bolen, B. Montgomery Pettitt
BIOPHYSICAL JOURNAL
(2007)
Article
Biochemistry & Molecular Biology
Miriam Gulotta, Linlin Qiu, Ruel Desamero, Joerg Roesgen, D. Wayne Bolen, Robert Callender
Article
Biochemistry & Molecular Biology
Jorg Rosgen, B. Montgomery Pettitt, David Wayne Bolen
Article
Biophysics
Allan Chris M. Ferreon, Josephine C. Ferreon, D. Wayne Bolen, Jorg Rosgen
BIOPHYSICAL JOURNAL
(2007)