Article
Multidisciplinary Sciences
Monika Jozsa, Tihol Ivanov Donchev, Rodolphe Sepulchre, Timothy O'Leary
Summary: Research has shown that a self-regulating signaling motif can generate reliable size-regulated switches by exploiting the breakdown of mass-action kinetics in chemical reaction systems. In synaptic and other small compartments, fluctuations are large due to low copy numbers of species, leading to a different behavior than typical mass-action kinetics.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biochemistry & Molecular Biology
Finn T. Roberts-Craig, Luke P. Worthington, Samuel P. O'Hara, Jeffrey R. Erickson, Alison K. Heather, Zoe Ashley
Summary: This review evaluates the role of different CaMKII splice variants in vascular pathological and physiological mechanisms, emphasizing the need for further research to understand their importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Qi-Ming Chen, Michael Fischer, Yuki Nojiri, Michael Renger, Edwar Xie, Matti Partanen, Stefan Pogorzalek, Kirill G. Fedorov, Achim Marx, Frank Deppe, Rudolf Gross
Summary: By measuring the non-equilibrium dynamics of a superconducting Duffing oscillator, we experimentally reconcile the classical and quantum descriptions and explain the classically regarded steady states as quantum metastable states. Our results reveal a smooth quantum state evolution behind a sudden dissipative phase transition and provide insights into the intriguing phenomena in driven-dissipative systems.
NATURE COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Chenhui Yan, Yanglin Zhu, Leixin Miao, Sebastian Fernandez-Mulligan, Emanuel Green, Ruobing Mei, Hengxin Tan, Binghai Yan, Chao-Xing Liu, Nasim Alem, Zhiqiang Mao, Shuolong Yang
Summary: Researchers have discovered tunable magnetic ground states in MnBi6Te10 by using magnetization measurements, angle-resolved photoemission spectroscopy, and transmission electron microscopy. They have demonstrated an energy gap at the Dirac point on the MnBi2Te4 termination in the ferromagnetic phase, and gapless topological surface states on all terminations in the antiferromagnetic MnBi6Te10. By analyzing the data, they have proposed a conceptual framework to explain how these defects can affect the overall magnetic ground state energy and be used to tune the magnetic topological orders.
Article
Physics, Multidisciplinary
Aleksandra Nelson, Titus Neupert, Tomas Bzdusek, A. Alexandradinata
Summary: The passage introduces a class of topological insulators that are considered trivial, with a delicate topology that can be nullified by adding trivial bands. This multicellular topology is neither stable nor fragile, but rather intricate in nature.
PHYSICAL REVIEW LETTERS
(2021)
Review
Pharmacology & Pharmacy
Olja Mijanovic, Anastasiia I. Petushkova, Ana Brankovic, Boris Turk, Anna B. Solovieva, Angelina I. Nikitkina, Sergey Bolevich, Peter S. Timashev, Alessandro Parodi, Andrey A. Zamyatnin
Summary: Lysosomal proteases, specifically human cathepsin D, play a crucial role in maintaining cell homeostasis by managing protein turnover. Dysregulation of cathepsin D can contribute to various disorders, such as neurodegenerative diseases and cancer progression. Targeting cathepsin D could provide significant diagnostic benefits and innovative therapeutic approaches.
Article
Biochemical Research Methods
G. HarshaRani, S. Moza, N. Ramakrishnan, U. S. Bhalla
Summary: This study presents a resource of over 35,000 reaction topologies for systematic surveys of bistable biochemical reaction networks, and provides a searchable database for analyzing stability in chemical systems.
Article
Chemistry, Multidisciplinary
Artem Grebenko, Anton Bubis, Konstantin Motovilov, Viacheslav Dremov, Evgeny Korostylev, Ivan Kindiak, Fedor S. Fedorov, Sergey Luchkin, Yuliya Zhuikova, Aleksandr Trofimenko, Gleb Filkov, Georgiy Sviridov, Andrey Ivanov, Jordan T. Dull, Rais Mozhchil, Andrey Ionov, Valery Varlamov, Barry P. Rand, Vitaly Podzorov, Albert G. Nasibulin
Summary: A new class of green and gentle lithographic resists has been developed, allowing compatibility with delicate materials and enabling fabrication of devices with sub-micron features. This approach opens up avenues for in-depth research of unconventional delicate materials at the nanoscale.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Multidisciplinary Sciences
Yuchi Huo, Hujun Bao, Yifan Peng, Chen Gao, Wei Hua, Qing Yang, Haifeng Li, Rui Wang, Sung-Eui Yoon
Summary: This research proposes a deep-learning paradigm, termed functional learning (FL), to physically train a loose neuron array, a group of non-handcrafted, non-differentiable, and loosely connected physical neurons whose connections and gradients are beyond explicit expression.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Nan Zhang, Wencong Sun, Yao Zhang, Huan-Huan Jiang, Ren-Gen Xiong, Shuai Dong, Han-Yue Zhang
Summary: Organic martensitic compounds are emerging smart materials with intriguing physical properties. The authors demonstrate that a series of 1,4,5,8-naphthalenediimide derivatives exhibit reversible ferroelectric and martensitic transitions with a large thermal hysteresis upon H/F substitution.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Multidisciplinary Sciences
Linda Nordling, Nolwazi Mbongwa
Summary: Nolwazi Mbongwa investigates cultural practices of traditional healers and collaborates with conservationists to protect wildlife.
News Item
Physics, Multidisciplinary
Ralf Roehlsberger
Summary: The near-zero thermal expansion of Invar alloy Fe65Ni35 is of technological importance and can be explained by the cancellation of magnetic and phonon contributions to the alloy's entropy.
Article
Multidisciplinary Sciences
Bogdan Y. Nikitchuk, Evgeny V. Anikin, Natalya S. Maslova, Nikolay A. Gippius
Summary: This paper studies the model of two coupled oscillators with Kerr nonlinearities in the rotating-wave approximation. It is demonstrated that multi-photon transitions occur simultaneously between many pairs of oscillator states when certain parameters are set in the model. Additionally, the position of multi-photon resonances is independent of the coupling strength between the oscillators. The authors rigorously prove that this is a result of a specific symmetry in the perturbation theory series of the model. Moreover, the model is analyzed in the quasi-classical limit by examining the dynamics of pseudo-angular momentum, and the multi-photon transitions are identified as tunneling transitions between degenerate classical trajectories on the Bloch sphere.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Michael Wagner, Mirna S. Sadek, Nataliya Dybkova, Fleur E. Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R. Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kaemmerer
Summary: The study found that overexpression of PDE2 can reduce the likelihood of ventricular arrhythmia, mainly by preventing the increase of cellular triggers mediated by Epac and CaMKII, indicating that activating myocardial PDE2 may be a novel intracellular antiarrhythmic therapeutic strategy in heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Joel Lee, Xiumin Chen, Roger A. Nicoll
Summary: Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) plays a critical role in long-term potentiation (LTP), but how LTP and memories survive the turnover of synaptic proteins remains a mystery. In this study, it was found that constitutive Ca2+-independent CaMKII activity acquired before slice preparation provides a lasting memory trace at synapses, which remains stable over a 2-week period in slice culture.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)