Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 7, Issue 15, Pages 8313-8318Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.5b01702
Keywords
G-quadruplex; iridium(III) complex; label-free; ochratoxin A; luminescent
Funding
- Hong Kong Baptist University [FRG2/13-14/008, FRG2/14-1.5/004]
- Centre for Cancer and Inflammation Research, School of Chinese Medicine (CCIR-SCM, HKBU)
- Health and Medical Research Fund [HMRF/13121482, HMRF/14130522]
- Research Grants Council [HKBU/201811, HKBU/204612, HKBU/201913]
- French National Research Agency/Research Grants Council Joint Research Scheme [A-HKBU201/12]
- State Key Laboratory of Environmental and Biological Analysis Research Grant [SKLP-14-15-P001]
- State Key Laboratory of Synthetic Chemistry
- Science and Technology Development Fund
- Macao SAR [103/2012/A3]
- University of Macau [MYRG091(Y3-L2)-ICMS12-LCH, MYRG2015-00137-ICMS-QRCM, MRG023/LCH/2013/ICMS]
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A library of six luminescent Ir(III) complexes were synthesized and studied for their capacity to function as probes for G-quadruplex DNA. The novel Ir(III) complex 1 was discovered to be selective for G-quadruplex structures and was subsequently used for the construction of a label-free G-quadruplex-based ochratoxin A (OTA) sensing platform in aqueous solution. The assay exhibited linearity for OTA in the range of 0 to 60 nM (R-2 = 0.9933), and the limit of detection for OTA was 5 nM. Furthermore, this assay was highly selective for OTA over its structurally related analogues.
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