Article
Pharmacology & Pharmacy
Samuel J. Bose, Matthew J. Read, Emily Akerman, Rebecca A. Capel, Thamali Ayagama, Angela Russell, Derek A. Terrar, Manuela Zaccolo, Rebecca A. B. Burton
Summary: Atrial arrhythmias, such as atrial fibrillation, are a major risk for mortality and stroke. This study found that AC1 is involved in the response of atrial tissue and cells to alpha-adrenoceptor stimulation and IP3R calcium release.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yufan Yang, Yuan Yuan, Johnson Wong, Michael C. Fishbein, Peng-Sheng Chen, Thomas H. Everett
Summary: It was found that stimulation of the right stellate ganglion (RSG) could increase local nerve activity at the sinoatrial node (SAN), accelerate sinus rate, and alter early activation sites in the heart. High-density mapping revealed that bursts of intrinsic nerve activity at the SAN occurred before each atrial activation during heart rate acceleration induced by RSG stimulation.
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew Amoni, Sebastian Ingelaere, Jonathan Moeyersons, Dries Wets, Aldo Tanushi, Sabine Van Huffel, Carolina Varon, Karin Sipido, Piet Claus, Rik Willems
Summary: The study demonstrates that beat-to-beat variability of repolarization (BVR) increases during acute myocardial ischemia (AMI) and surges before the onset of ventricular arrhythmia (VT/VF). This suggests that monitoring BVR may be useful for assessing the risk of VT/VF during and after AMI. BVR also correlates with arrhythmia vulnerability, indicating its potential utility in risk stratification post-AMI.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Tawfiq Khurayzi, Fida Almuhawas, Abdulrahman Alsanosi, Yassin Abdelsamad, Una Doyle, Anandhan Dhanasingh
Summary: This study evaluated the performance of the A-value and a novel C-value in distinguishing normal cochleae from malformed ones. The results showed significant differences in A-values between normal and malformed cochleae, while the C-value was more accurate in predicting malformed anatomy.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Divyansh Mittal, Rishikesh Narayanan
Summary: In this study, the oscillatory patterns of stellate cells (SC) in the medial entorhinal cortex were investigated. The researchers found that these patterns vary between cells and can be influenced by noise. Through experimental recordings and modeling, they discovered the presence of stochastic resonance and identified a network motif that contributes to the emergence of oscillations. These findings suggest that the oscillatory activity of SCs is state-dependent and can be modulated by external factors.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Yusheng Wu, Guidi Zhou, Guifen Wang, Xuhua Cheng
Summary: This study evaluates the relative importance of forced and intrinsic SST variability in the Kuroshio-Oyashio Extension (KOE) region on submonthly timescales. The results show that forced SST variability accounts for a very small fraction of the total variability in the KOE region, indicating the dominance of intrinsic oceanic processes.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Tristan W. Dorey, Hailey J. Jansen, Motahareh Moghtadaei, K. Lockhart Jamieson, Robert A. Rose
Summary: HRV decreases with aging in mice, with a shift in sympathovagal balance and increased intrinsic SAN beating variability. Frailty index (FI) is strongly correlated with HRV, detecting differences independent of chronological age.
Article
Physiology
Motahareh Moghtadaei, Tristan W. Dorey, Robert A. Rose
Summary: Nonlinear analyses of heart rate variability can quantify the unpredictability, fractal properties, and complexity of heart rate, providing valuable information about cardiovascular health. The Multi-Scale Multi-Fractal Detrended Fluctuation Analysis algorithm is applicable to short time series and robust to noise and nonstationarity, enabling the assessment of HRV at different scales and fractal dynamics. The fractal properties of HRV depend on both the autonomic nervous system activity and intrinsic sinoatrial node function, and evaluating multi-fractality at different time scales is an effective approach for HRV assessment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physics, Fluids & Plasmas
Soutrick Das, Debashis Barik
Summary: Biochemical reactions in living cells often produce stochastic trajectories due to fluctuations of macromolecular species. This study investigates the origins and regulation of stochasticity in small regulatory networks, finding that networks resemble social networks in hierarchical structure. The study shows that noise in the network scales unconventionally with abundance, influenced by bursty kinetics of trajectories. The scaling remains intact even in mixed networks with democratic subnetworks.
Article
Medicine, General & Internal
C. Livadaru, S. Morarasu, D. Ferariu, S. Lunca, G. Dimofte
Summary: This study aimed to evaluate the anatomical variability of the colic artery from origin to the tumor margin (RAL) and its prognostic value by correlating it with LN parameters. The results showed no significant correlation between RAL and LN count, and the large anatomical variability of RAL makes it an impractical surgical quality instrument.
MEDICAL-SURGICAL JOURNAL-REVISTA MEDICO-CHIRURGICALA
(2022)
